HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 136 matching records:

Displaying record number 57523

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 57132

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) (B*4801, B*5703)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining, Relative replication capacity assay
Keywords escape, HLA associated polymorphism

Notes

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.


Displaying record number 58494

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 54793

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 58357

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name B57 KF11
Subtype B, C
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection, vaccine
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine antigen design

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine strain B clade, C clade
Vaccine component Gag

Notes

References

Ndhlovu2011 Zaza M. Ndhlovu, Alicja Piechocka-Trocha, Seanna Vine, Ashley McMullen, Kegakilwe C. Koofhethile, Phillip J. R. Goulder, Thumbi Ndung'u, Dan H. Barouch, and Bruce D. Walker. Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells. J. Immunol., 186(12):6914-6924, 15 Jun 2011. PubMed ID: 21576505. Show all entries for this paper.


Displaying record number 58282

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.


Displaying record number 54271

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 58741

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172 NL4-3)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords elite controllers

Notes

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 61240

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.


Displaying record number 59132

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40 NL4.3)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infected monocyte-derived, HIV-1 infection
Country United States
Experimental methods Chromium-release assay, Other
Keywords epitope processing, dendritic cells

Notes

References

Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.


Displaying record number 53776

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype B, C
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords subtype comparisons, escape, viral fitness and reversion, optimal epitope

Notes

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


Displaying record number 58803

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name B*57-KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods Other, Tetramer binding
Keywords  

Notes

References

Conrad2012 Joseph A. Conrad, Ramesh K. Ramalingam, Coley B. Duncan, Rita M. Smith, Jie Wei, Louise Barnett, Brenna C. Simons, Shelly L. Lorey, and Spyros A. Kalams. Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance. J. Virol., 86(8):4213-4221, Apr 2012. PubMed ID: 22258246. Show all entries for this paper.


Displaying record number 58767

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name Gag-KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 1176

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Spiegel1999 H. M. Spiegel, E. DeFalcon, G. S. Ogg, M. Larsson, T. J. Beadle, P. Tao, A. J. McMichael, N. Bhardwaj, C. O'Callaghan, W. I. Cox, K. Krasinski, H. Pollack, W. Borkowsky, and D. F. Nixon. Changes in Frequency of HIV-1-Specific Cytotoxic T Cell Precursors and Circulating Effectors after Combination Antiretroviral Therapy in Children. J. Infect. Dis., 180:359-368, 1999. PubMed ID: 10395850. Show all entries for this paper.


Displaying record number 58004

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Cytotoxicity assay, Other
Keywords epitope processing

Notes

References

Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.


Displaying record number 53123

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 59382

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55112

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords characterizing CD8+ T cells

Notes

References

Addo2007 Marylyn M. Addo, Rika Draenert, Almas Rathod, Cori L. Verrill, Benjamin T. Davis, Rajesh T. Gandhi, Gregory K. Robbins, Nesli O. Basgoz, David R. Stone, Daniel E. Cohen, Mary N. Johnston, Theresa Flynn, Alysse G. Wurcel, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection. PLoS ONE, 2(3):e321, 2007. PubMed ID: 17389912. Show all entries for this paper.


Displaying record number 59190

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40 NL4.3)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Other
Keywords epitope processing

Notes

References

Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.


Displaying record number 59139

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 55332

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords rate of progression, acute/early infection, memory cells

Notes

References

Sabbaj2007 Steffanie Sabbaj, Sonya L. Heath, Anju Bansal, Sameera Vohra, J Michael Kilby, Allan J. Zajac, and Paul A. Goepfert. Functionally Competent Antigen-Specific CD127(hi) Memory CD8+ T Cells Are Preserved Only in HIV-Infected Individuals Receiving Early Treatment. J. Infect. Dis., 195(1):108-117, 1 Jan 2007. PubMed ID: 17152014. Show all entries for this paper.


Displaying record number 61562

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name B57-KF11(p24)
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA OP246: A*01, A*02, B*51, B*57, Cw*06; P1004: A*02, B*08, B*57, Cw*06, Cw*07; AC-43: A*24, A*31, B*14, B*57, Cw*07, Cw*08; AC-38: A*01, A*03, B*07, B*57, Cw*06, Cw*07; AC-108: A*02, B*57, B*61, Cw*03, Cw*06; AC-109: A*01, A*02, B*14, B*57, Cw*07, Cw*08
Country Canada, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords acute/early infection, protective allele

Notes

References

Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.


Displaying record number 55768

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, elite controllers

Notes

References

Bailey2008 Justin R. Bailey, Karen O'Connell, Hung-Chih Yang, Yefei Han, Jie Xu, Benjamin Jilek, Thomas M. Williams, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Transmission of Human Immunodeficiency Virus Type 1 from a Patient Who Developed AIDS to an Elite Suppressor. J. Virol., 82(15):7395-7410, Aug 2008. PubMed ID: 18495769. Show all entries for this paper.


Displaying record number 59028

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses, therapeutic vaccine

Vaccine Details

Vaccine type DNA prime with Ad5 boost
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol

Notes

References

Casazza2013 Joseph P. Casazza, Kathryn A. Bowman, Selorm Adzaku, Emily C. Smith, Mary E. Enama, Robert T. Bailer, David A. Price, Emma Gostick, Ingelise J. Gordon, David R. Ambrozak, Martha C. Nason, Mario Roederer, Charla A. Andrews, Frank M. Maldarelli, Ann Wiegand, Mary F. Kearney, Deborah Persaud, Carrie Ziemniak, Raphael Gottardo, Julie E. Ledgerwood, Barney S. Graham, Richard A. Koup, and VRC 101 Study Team. Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire. J. Infect. Dis., 207(12):1829-1840, 15 Jun 2013. PubMed ID: 23482645. Show all entries for this paper.


Displaying record number 62010

HXB2 Location Gag(162-172)
p24(30-40)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name B*57-KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords binding affinity, structure, assay or method development, contact residues

Notes

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.


Displaying record number 56342

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(16-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B, C
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 56377

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 58971

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172 NL4-3)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen in vitro stimulation or selection
Experimental methods CTL suppression of replication, In vitro proteasome digestion, Other
Keywords epitope processing, class I down-regulation by Nef, kinetics

Notes

References

Balamurugan2013 Arumugam Balamurugan, Ayub Ali, Julie Boucau, Sylvie Le Gall, Hwee L. Ng, and Otto O. Yang. HIV-1 Gag Cytotoxic T Lymphocyte Epitopes Vary in Presentation Kinetics Relative to HLA Class I Downregulation. J. Virol., 87(15):8726-8734, Aug 2013. PubMed ID: 23740989. Show all entries for this paper.


Displaying record number 62109

HXB2 Location Gag(162-172)
p24(30-40)
Gag Epitope Map
Author Location p24(162-172 NL4-3)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*57)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 56754

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


Displaying record number 57247

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 57259

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype A1, D
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape

Notes

References

McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.


Displaying record number 57354

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(240-249)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Relative replication capacity assay
Keywords escape, mutation acquisition, elite controllers

Notes

References

Miura2009a Toshiyuki Miura, Mark A. Brockman, Arne Schneidewind, Michael Lobritz, Florencia Pereyra, Almas Rathod, Brian L. Block, Zabrina L. Brumme, Chanson J. Brumme, Brett Baker, Alissa C. Rothchild, Bin Li, Alicja Trocha, Emily Cutrell, Nicole Frahm, Christian Brander, Ildiko Toth, Eric J. Arts, Todd M. Allen, and Bruce D. Walker. HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition. J Virol, 83(6):2743-2755, Mar 2009. PubMed ID: 19116253. Show all entries for this paper.


Displaying record number 57400

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 57414

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Durand2010 Christine M. Durand, Karen A. O'Connell, Linda G. Apuzzo, Susan J. Langan, Hejab Imteyaz, Aima A. Ahonkhai, Christina M. Ceccato, Thomas M. Williams, Joseph B. Margolick, and Joel N. Blankson. HIV-1 Gag Evolution in Recently Infected Human Leukocyte Antigen-B*57 Patients with Low-Level Viremia. AIDS, 24(15):2405-2408, 24 Sep 2010. PubMed ID: 20671542. Show all entries for this paper.


Displaying record number 57416

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining
Keywords elite controllers

Notes

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


Displaying record number 58815

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords elite controllers

Notes

References

Ndhlovu2012 Zaza M. Ndhlovu, Jacqueline Proudfoot, Kevin Cesa, Donna Marie Alvino, Ashley McMullen, Seanna Vine, Eleni Stampouloglou, Alicja Piechocka-Trocha, Bruce D. Walker, and Florencia Pereyra. Elite Controllers with Low to Absent Effector CD8+ T Cell Responses Maintain Highly Functional, Broadly Directed Central Memory Responses. J. Virol., 86(12):6959-3969, Jun 2012. PubMed ID: 22514340. Show all entries for this paper.


Displaying record number 60640

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF-11
Subtype B, C
Species (MHC/HLA) human(B*57, B*5701, B*5703, B*58, B*5801, B*63)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 57592

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) (B*57, B*58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 57776

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Relative replication capacity assay
Keywords responses in children, rate of progression

Notes

References

Prado2010 Julia G. Prado, Andrew Prendergast, Christina Thobakgale, Claudia Molina, Gareth Tudor-Williams, Thumbi Ndung'u, Bruce D. Walker, and Philip Goulder. Replicative Capacity of Human Immunodeficiency Virus Type 1 Transmitted from Mother to Child Is Associated with Pediatric Disease Progression Rate. J. Virol., 84(1):492-502, Jan 2010. PubMed ID: 19828603. Show all entries for this paper.


Displaying record number 57685

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords immunodominance, characterizing CD8+ T cells

Notes

References

Mkhwanazi2010 Nompumelelo Mkhwanazi, Christina F. Thobakgale, Mary van der Stok, Shabashini Reddy, Zenele Mncube, Fundisiwe Chonco, Bruce D. Walker, Marcus Altfeld, Philip J. R. Goulder, and Thumbi Ndung'u. Immunodominant HIV-1-Specific HLA-B- and HLA-C-Restricted CD8+ T Cells Do Not Differ in Polyfunctionality. Virology, 405(2):483-491, 30 Sep 2010. PubMed ID: 20638093. Show all entries for this paper.


Displaying record number 55670

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Chopera2008 Denis R. Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P. Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M. Gray, Carolyn Williamson, and CAPRISA 002 Study Team. Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage. PLoS Pathog, 4(3):e1000033, Mar 2008. PubMed ID: 18369479. Show all entries for this paper.


Displaying record number 57191

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(329-343)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Patient MHC/HLA B*27, B57; B*27, B*5801; B*57; B*57; B*57
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, autologous responses, elite controllers

Notes

References

OConnell2010 Karen A. O'Connell, Timothy P. Brennan, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Control of HIV-1 in Elite Suppressors Despite Ongoing Replication and Evolution in Plasma Virus. J. Virol., 84(14):7018-7028, Jul 2010. PubMed ID: 20444904. Show all entries for this paper.


Displaying record number 55047

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 164

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 1175

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24( SF2)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 1297

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag( SF2)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 1380

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KAF
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 1411

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kostense2001 S. Kostense, G. S. Ogg, E. H. Manting, G. Gillespie, J. Joling, K. Vandenberghe, E. Z. Veenhof, D. van Baarle, S. Jurriaans, M. R. Klein, and F. Miedema. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur. J. Immunol., 31(3):677-86, Mar 2001. PubMed ID: 11241270. Show all entries for this paper.


Displaying record number 1555

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172 SF2)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1708

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(163-174)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.


Displaying record number 52325

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KAF
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 52622

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A3, B44, B57, Cw5, Cw6
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 52728

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining
Keywords immunodominance, genital and mucosal immunity

Notes

References

Kaul2003 Rupert Kaul, Paul Thottingal, Joshua Kimani, Peter Kiama, Charles W. Waigwa, Job J. Bwayo, Francis A. Plummer, and Sarah L. Rowland-Jones. Quantitative Ex Vivo Analysis of Functional Virus-Specific CD8 T Lymphocytes in the Blood and Genital Tract of HIV-Infected Women. AIDS, 17(8):1139-1144, May 2003. PubMed ID: 12819514. Show all entries for this paper.


Displaying record number 52844

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(163-174)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A3, B57, Cw*06, Cw*07; A*01, A*0201, B*08, B*57, Cw6, Cw7
Country United States
Experimental methods Cytokine production, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords TCR usage

Notes

References

Betts2004 Michael R. Betts, David A. Price, Jason M. Brenchley, Karin Loré, F. Javier Guenaga, Anna Smed-Sorensen, David R. Ambrozak, Stephen A. Migueles, Mark Connors, Mario Roederer, Daniel C. Douek, and Richard A. Koup. The Functional Profile of Primary Human Antiviral CD8+ T Cell Effector Activity Is Dictated by Cognate Peptide Concentration. J. Immunol., 172(10):6407-6417, 15 May 2004. PubMed ID: 15128832. Show all entries for this paper.


Displaying record number 52920

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords epitope processing, escape

Notes

References

Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.


Displaying record number 52924

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(155-172 B con)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Draenert2004b R. Draenert, C. L. Verrill, Y. Tang, T. M. Allen, A. G. Wurcel, M. Boczanowski, A. Lechner, A. Y. Kim, T. Suscovich, N. V. Brown, M. M. Addo, and B. D. Walker. Persistent Recognition of Autologous Virus by High-Avidity CD8 T Cells in Chronic, Progressive Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(2):630-641, Jan 2004. PubMed ID: 14694094. Show all entries for this paper.


Displaying record number 53045

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 53205

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location (162-172 B consensus)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords immunodominance, characterizing CD8+ T cells

Notes

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.


Displaying record number 53308

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location ( C consensus)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 53406

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods Intracellular cytokine staining, T-cell Elispot, Tetramer binding
Keywords rate of progression, acute/early infection, characterizing CD8+ T cells

Notes

References

Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.


Displaying record number 53493

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53549

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 159

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Goulder2000a P. J. Goulder, Y. Tang, S. I. Pelton, and B. D. Walker. HLA-B57-Restricted Cytotoxic T-Lymphocyte Activity in a Single Infected Subject toward Two Optimal Epitopes, One of Which Is Entirely Contained Within the Other. J. Virol., 74:5291-5299, 2000. PubMed ID: 10799606. Show all entries for this paper.


Displaying record number 53733

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172 BRU)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B, CRF02_AG
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 53741

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KAF
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords binding affinity, rate of progression, escape, characterizing CD8+ T cells

Notes

References

Jansen2005a Christine A. Jansen, Stefan Kostense, Kristin Vandenberghe, Nening M. Nanlohy, Iris M. De Cuyper, Erwan Piriou, Erik H. Manting, Frank Miedema, and Debbie van Baarle. High Responsiveness of HLA-B57-Restricted Gag-Specific CD8+ T Cells In Vitro May Contribute to the Protective Effect of HLA-B57 in HIV-Infection. Eur. J. Immunol., 35(1):150-158, Jan 2005. PubMed ID: 15593302. Show all entries for this paper.


Displaying record number 54394

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name B57-KF11(p24)
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54527

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 54871

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 57598

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, genital and mucosal immunity

Notes

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.


Displaying record number 57980

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, elite controllers

Notes

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.


Displaying record number 55108

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, mutation acquisition, optimal epitope

Notes

References

Streeck2007a Hendrik Streeck, Mathias Lichterfeld, Galit Alter, Angela Meier, Nickolas Teigen, Bader Yassine-Diab, Harlyn K. Sidhu, Susan Little, Anthony Kelleher, Jean-Pierre Routy, Eric S. Rosenberg, Rafick-Pierre Sekaly, Bruce D. Walker, and Marcus Altfeld. Recognition of a Defined Region within p24 Gag by CD8+ T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles. J. Virol., 81(14):7725-7731, Jul 2007. PubMed ID: 17494064. Show all entries for this paper.


Displaying record number 55163

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11 ?
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords memory cells

Notes

References

Wherry2006 E John Wherry, Cheryl L. Day, Rika Draenert, Joseph D. Miller, Photini Kiepiela, Tonia Woodberry, Christian Brander, Marylyn Addo, Paul Klenerman, Rafi Ahmed, and Bruce D. Walker. HIV-Specific CD8 T Cells Express Low Levels of IL-7Ralpha: Implications for HIV-Specific T Cell Memory. Virology, 353(2):366-373, 30 Sep 2006. PubMed ID: 16860834. Show all entries for this paper.


Displaying record number 55184

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords responses in children, rate of progression

Notes

References

Chakraborty2005 Rana Chakraborty, Anne-Sophie Morel, Julian K. Sutton, Victor Appay, Ruth M. Ripley, Tao Dong, Tim Rostron, Simon Ogola, Tresa Palakudy, Rachel Musoke, Angelo D'Agostino, Mary Ritter, and Sarah L. Rowland-Jones. Correlates of Delayed Disease Progression in HIV-1-Infected Kenyan Children. J. Immunol., 174(12):8191-8199, 15 Jun 2005. PubMed ID: 15944328. Show all entries for this paper.


Displaying record number 55613

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 57978

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, elite controllers

Notes

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.


Displaying record number 57974

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, elite controllers

Notes

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.


Displaying record number 56308

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172 SF2, HXBc2/Bal R5)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A2, B40, B57, Cw3, Cw6
Country United States
Experimental methods Cytokine production, Degranulation, CD107a and b cell surface mobilization, Flow cytometric T-cell cytokine assay
Keywords supervised treatment interruptions (STI), immunodominance, characterizing CD8+ T cells, drug resistance

Notes

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 57839

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 57688

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Germany, United States
Experimental methods Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords memory cells

Notes

References

Meyer-Olson2010 Dirk Meyer-Olson, Brenna C. Simons, Joseph A. Conrad, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Coley B. Duncan, Ramesh Ramalingam, and Spyros A. Kalams. Clonal Expansion and TCR-Independent Differentiation Shape the HIV-Specific CD8+ Effector-Memory T-Cell Repertoire In Vivo. Blood, 116(3):396-405, Jul 22 2010. PubMed ID: 20424187. Show all entries for this paper.


Displaying record number 52194

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2002 Rupert Kaul, Sarah L. Rowland-Jones, Geraldine Gillespie, Joshua Kimani, Tao Dong, Peter Kiama, J. Neil Simonsen, Job J. Bwayo, Andrew J. McMichael, and Francis A. Plummer. Gonococcal Cervicitis is Associated with Reduced Systemic CD8+ T Cell Responses in Human Immunodeficiency Virus Type 1-Infected and Exposed, Uninfected Sex Workers. J. Infect. Dis., 185(10):1525-1529, 15 May 2002. PubMed ID: 11992292. Show all entries for this paper.


Displaying record number 1695

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(153-164)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), immunodominance

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 53642

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords responses in children, mother-to-infant transmission, escape, characterizing CD8+ T cells

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 56751

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location ( pMJ5)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*5801, B57)
Immunogen in vitro stimulation or selection
Experimental methods Relative replication capacity assay
Keywords escape, viral fitness and reversion

Notes

References

Boutwell2009 Christian L Boutwell, Christopher F Rowley, and M Essex. Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein. J Virol, 83(6):2460-8, Mar 2009. PubMed ID: 19109381. Show all entries for this paper.


Displaying record number 53655

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B, C
Species (MHC/HLA) human(B57, B63)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, HLA cross-presentation, optimal epitope

Notes

References

Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.


Displaying record number 59165

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name gag 162-172
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 52086

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 59208

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA P1: B*5701; P6: B*5701
Country United States
Experimental methods Other
Keywords elite controllers

Notes

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 52082

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 52760

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KAF11
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, escape

Notes

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.


Displaying record number 62172

HXB2 Location Gag(162-172)
p24(30-40)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods HLA binding
Keywords binding affinity, NK cells

Notes

References

Martin2018 Maureen P. Martin, Vivek Naranbhai, Patrick R. Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L. Brumme, Jonathan M. Carlson, Steven M. Wolinsky, James J. Goedert, Bruce D. Walker, Florencia P. Segal, Steven G. Deeks, David W. Haas, Stephen A. Migueles, Mark Connors, Nelson Michael, Jacques Fellay, Emma Gostick, Sian Llewellyn-Lacey, David A. Price, Bernard A. Lafont, Phillip Pymm, Philippa M. Saunders, Jacqueline Widjaja, Shu Cheng Wong, Julian P. Vivian, Jamie Rossjohn, Andrew G. Brooks, and Mary Carrington. Killer Cell Immunoglobulin-Like Receptor 3DL1 Variation Modifies HLA-B*57 Protection against HIV-1. J. Clin. Invest., 128(5):1903-1912, 1 May 2018. PubMed ID: 29461980. Show all entries for this paper.


Displaying record number 57996

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype C
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 55001

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KAF
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords rate of progression, TCR usage, variant cross-reactivity

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 57914

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords  

Notes

References

Fadda2011 Lena Fadda, Geraldine M. O'Connor, Swati Kumar, Alicja Piechocka-Trocha, Clair M. Gardiner, Mary Carrington, Daniel W. McVicar, and Marcus Altfeld. Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules. J Virol, 85(12):5970-5974, Jun 2011. PubMed ID: 21471246. Show all entries for this paper.


Displaying record number 54745

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords binding affinity

Notes

References

Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.


Displaying record number 58676

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172 NL4-3)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA R039: A*0101, A*3101, B*2705, B*5701, Cw*0202, Cw*0602
Country United Kingdom
Experimental methods Intracellular cytokine staining, Other
Keywords acute/early infection

Notes

References

Kloverpris2013 Henrik N. Kløverpris, Rebecca P. Payne, Jonah B. Sacha, Jane T. Rasaiyaah, Fabian Chen, Masafumi Takiguchi, Otto O. Yang, Greg J. Towers, Philip Goulder, and Julia G. Prado. Early Antigen Presentation of Protective HIV-1 KF11Gag and KK10Gag Epitopes from Incoming Viral Particles Facilitates Rapid Recognition of Infected Cells by Specific CD8+ T Cells. J. Virol., 87(5):2628-2638, Mar 2013. PubMed ID: 23255798. Show all entries for this paper.


Displaying record number 162

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172 LAI)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression

Notes

References

Goulder1996 P. J. R. Goulder, M. Bunce, P. Krausa, K. McIntyre, S. Crowley, B. Morgan, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Novel, Cross-Restricted, Conserved and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow HIV Type 1 Infection. AIDS Res. Hum. Retroviruses, 12:1691-1698, 1996. HLA-B*57 is over-represented in slow progressors. HLA*5801 is a closely related molecule, and while the defined anchor residues of HLA*5801 can be used to predict epitopes in HIV-1 proteins, the CTL from HLA-B*57 positive individuals have limited cross-presentation capacity with HLA*5801 targets. In this paper five new HLA-B*57 epitopes were defined. PubMed ID: 8959245. Show all entries for this paper.


Displaying record number 163

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172 LAI)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58840

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*2705, B*5701; A*0101, A*2402, B*4002, B*5701; A*2402, A*3201, B*4002, B*5701; A*0101, A*0201, B*5101, B*5701; A*0101, A*0101, B*0801, B*5701; A*0301, A*2402, B*3501, B*5701
Country United States
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression

Notes

References

Norstrom2012 Melissa M. Norström, Marcus Buggert, Johanna Tauriainen, Wendy Hartogensis, Mattia C. Prosperi, Mark A. Wallet, Frederick M. Hecht, Marco Salemi, and Annika C. Karlsson. Combination of Immune and Viral Factors Distinguishes Low-Risk Versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects. J. Virol., 86(18):9802-9816, Sep 2012. PubMed ID: 22761389. Show all entries for this paper.


Displaying record number 58963

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA 21746: A*0101, A*4801, B*4001, B*5701, Cw*0304, Cw*0602; 10849: A*2301, A*6801, B*3543, B*5703, Cw*0102, Cw*0210; 67200: A*0101, A*2401, B*0801, B*5701, Cw*0602, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61576

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B*5701, B*5702, B*5703)
Immunogen vaccine
Experimental methods Other
Keywords review, vaccine-induced immune responses, vaccine antigen design, protective allele

Notes

References

Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.


Displaying record number 54625

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, HLA associated polymorphism, elite controllers

Notes

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 61214

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, escape, HLA associated polymorphism

Notes

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


Displaying record number 61197

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, TCR usage

Notes

References

Gras2008 Stephanie Gras, Lars Kjer-Nielsen, Scott R. Burrows, James McCluskey, and Jamie Rossjohn. T-Cell Receptor Bias and Immunity. Curr. Opin. Immunol., 20(1):119-125, Feb 2008. PubMed ID: 18207719. Show all entries for this paper.


Displaying record number 59010

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B, C
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Patient MHC/HLA R039: A*0101, A*3101, B*2705, B*5701, Cw*0202, Cw*0602; R059: A*0103, A*6802, B*3501, B*5703, C*0501, C*0701; R014: A*3001, A*3301, B*4201, B*5703, C*1701, C*1801; R007: A*2402, A*8001, B*0702, B*5801, C*0202, C*0302; R036: A*0201, A*6802, B*1401, B*5801, C*0302, C*0802; N056: A*0201, A*0214, B*1503, B*1801, C*0210, C*0401; N087: A*0301, A*3001, B*5703, B*5801, C*0602, C*1801; K140: A*0301, A*6801, B*5703, B*5801, C*0302, C*0701; K061: A*0301, A*6601, B*5703, B*5801, C*0302, C*1801; 468: A*0202, A*6801, B*5703, B*5801, C*0602, C*0701
Country South Africa, United Kingdom
Experimental methods HLA binding
Keywords epitope processing

Notes

References

Kloverpris2013b Henrik N. Kløverpris, Anette Stryhn, Mikkel Harndahl, Rebecca Payne, Greg J. Towers, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Alasdair Leslie, Soren Buus, and Philip Goulder. HLA-Specific Intracellular Epitope Processing Shapes an Immunodominance Pattern for HLA-B*57 That Is Distinct from HLA-B*58:01. J. Virol., 87(19):10889-10894, Oct 2013. PubMed ID: 23864640. Show all entries for this paper.


Displaying record number 58795

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen  
Experimental methods  
Keywords review

Notes

References

Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.


Displaying record number 55053

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords subtype comparisons, HLA cross-presentation, variant cross-reactivity

Notes

References

Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.


Displaying record number 55766

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords TCR usage

Notes

References

Simons2008 Brenna C. Simons, Scott E. VanCompernolle, Rita M. Smith, Jie Wei, Louise Barnett, Shelly L. Lorey, Dirk Meyer-Olson, and Spyros A. Kalams. Despite Biased TRBV Gene Usage against a Dominant HLA B57-Restricted Epitope, TCR Diversity Can Provide Recognition of Circulating Epitope Variants. J. Immunol., 181(7):5137-5146, 1 Oct 2008. PubMed ID: 18802118. Show all entries for this paper.


Displaying record number 54815

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords immunodominance, TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 55092

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype B, C
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Country India, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Proliferation
Keywords subtype comparisons, escape, TCR usage, mutation acquisition

Notes

References

Yu2007a Xu G Yu, Mathias Lichterfeld, Senica Chetty, Katie L. Williams, Stanley K. Mui, Toshiyuki Miura, Nicole Frahm, Margaret E. Feeney, Yanhua Tang, Florencia Pereyra, Montiago X. Labute, Katja Pfafferott, Alisdair Leslie, Hayley Crawford, Rachel Allgaier, William Hildebrand, Richard Kaslow, Christian Brander, Todd M. Allen, Eric S. Rosenberg, Photini Kiepiela, Madhu Vajpayee, Paul A. Goepfert, Marcus Altfeld, Philip J. R. Goulder, and Bruce D Walker. Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes. J. Virol., 81(4):1619-1631, Feb 2007. PubMed ID: 17121793. Show all entries for this paper.


Displaying record number 59380

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype B, C
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Country Barbados, Botswana, Spain, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Relative replication capacity assay, TCR binding
Keywords subtype comparisons, variant cross-reactivity

Notes

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.


Displaying record number 52191

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KAFS
Subtype A, B
Species (MHC/HLA) human(B*5701, B*5703)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, rate of progression

Notes

References

Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.


Displaying record number 53635

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country Ethiopia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, escape, variant cross-reactivity

Notes

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.


Displaying record number 56590

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(161-171)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 56470

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype C
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 57990

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype C
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 58423

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype A1
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 58684

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Show epitope variants
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HLA associated polymorphism

Notes

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.


Displaying record number 53921

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location ( C consensus)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype C
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 57440

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KAF-11
Species (MHC/HLA) human(B*5703)
Immunogen peptide-HLA interaction
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords structure

Notes

References

Stewart-Jones2005 Guillaume B. E. Stewart-Jones, Geraldine Gillespie, Ian M. Overton, Rupert Kaul, Philippe Roche, Andrew J. McMichael, Sarah Rowland-Jones, and E. Yvonne Jones. Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression. J. Immunol., 175(4):2459-2468, 15 Aug 2005. PubMed ID: 16081817. Show all entries for this paper.


Displaying record number 1976

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(20-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name Gag-KF11; p24-KF11
Subtype B
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Patient MHC/HLA 00RCH59: A*3402, A*7401, B*0801, B*5703, Cw*0302, Cw*0701
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 165

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(162-172 LAI)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 62165

HXB2 Location Gag(162-172)
p24(30-40)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name Gag-KF11
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape, HLA associated polymorphism

Notes

References

Avila-Rios2019 Santiago Avila-Rios, Jonathan M. Carlson, Mina John, Simon Mallal, and Zabrina L. Brumme. Clinical and Evolutionary Consequences of HIV Adaptation to HLA: Implications for Vaccine and Cure. Curr. Opin. HIV AIDS, 14(3):194-204, May 2019. PubMed ID: 30925534. Show all entries for this paper.


Displaying record number 55863

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype A, B
Species (MHC/HLA) human(B58)
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons

Notes

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.


Displaying record number 1462

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24(30-40)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B58)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 53704

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Subtype B, G
Species (MHC/HLA) human(B58)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A36, B45, B58, Cw3, Cw6
Country Nigeria
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 57885

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype C
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Patient MHC/HLA A*0205, A*2601, B*0705, B*5801, Cw*0701, Cw*0702
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.


Displaying record number 54137

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human(B*63)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59887

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(C*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59886

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56734

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag(162-172 NL4-3)
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods Other
Keywords escape

Notes

References

Crawford2009 Hayley Crawford, Wendy Lumm, Alasdair Leslie, Malinda Schaefer, Debrah Boeras, Julia G. Prado, Jianming Tang, Paul Farmer, Thumbi Ndung'u, Shabir Lakhi, Jill Gilmour, Paul Goepfert, Bruce D. Walker, Richard Kaslow, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Evolution of HLA-B*5703 HIV-1 Escape Mutations in HLA-B*5703-Positive Individuals and Their Transmission Recipients. J. Exp. Med., 206(4):909-921, 13 Apr 2009. PubMed ID: 19307327. Show all entries for this paper.


Displaying record number 57733

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords assay or method development, characterizing CD8+ T cells

Notes

References

Vollbrecht2010 Thomas Vollbrecht, Heike Brackmann, Nadja Henrich, Joerg Roeling, Ulrich Seybold, Johannes R. Bogner, Frank D. Goebel, and Rika Draenert. Impact of Changes in Antigen Level on CD38/PD-1 Co-Expression on HIV-Specific CD8 T Cells in Chronic, Untreated HIV-1 Infection. J. Med. Virol., 82(3):358-370, Mar 2010. PubMed ID: 20087935. Show all entries for this paper.


Displaying record number 61342

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


Displaying record number 61640

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Epitope Name KF11
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Canada
Experimental methods Chromium-release assay, Other
Keywords epitope processing, escape

Notes

References

Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.


Displaying record number 1336

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.


Displaying record number 55100

HXB2 Location Gag(162-172)
p24(30-40)
DNA(1273..1305)
Gag Epitope Map
Author Location  
Epitope KAFSPEVIPMF Epitope Alignment
KAFSPEVIPMF epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords binding affinity, acute/early infection

Notes

References

Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.


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