HIV molecular immunology database
Found 144 matching records:
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(A*02:01) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Tetramer binding | |
Keywords |
Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | (B*48:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | Intracellular cytokine staining, Relative replication capacity assay | |
Keywords | escape, HLA associated polymorphism |
Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | in vitro stimulation or selection, engineered, virus | |
Experimental methods | CTL suppression of replication, Chromium-release assay, Peptide titration | |
Keywords | assay or method development, variant cross-reactivity, characterizing CD8+ T cells, neutralization by CTL |
Balamurugan2018 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones. J. Virol., 92(16), 15 Aug 2018. PubMed ID: 29899094. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Chromium-release assay, Cytotoxicity assay, Other | |
Keywords | epitope processing |
Lazaro2011 Estibaliz Lazaro, Carl Kadie, Pamela Stamegna, Shao Chong Zhang, Pauline Gourdain, Nicole Y. Lai, Mei Zhang, Sergio A. Martinez, David Heckerman, and Sylvie Le Gall. Variable HIV Peptide Stability in Human Cytosol Is Critical to Epitope Presentation and Immune Escape. J. Clin. Invest., 121(6):2480-2492, Jun 2011. PubMed ID: 21555856. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | S00036: A*02, A*11, B*39, B*57, C*06, C*07; S00052: A*01, A*25, B*18, B*57, C*06, C*12 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | dynamics, chronic infection |
Balamurugan2017 Arumugam Balamurugan, Deon Claiborne, Hwee L. Ng, and Otto O. Yang. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28592539. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART |
Spiegel1999 H. M. Spiegel, E. DeFalcon, G. S. Ogg, M. Larsson, T. J. Beadle, P. Tao, A. J. McMichael, N. Bhardwaj, C. O'Callaghan, W. I. Cox, K. Krasinski, H. Pollack, W. Borkowsky, and D. F. Nixon. Changes in Frequency of HIV-1-Specific Cytotoxic T Cell Precursors and Circulating Effectors after Combination Antiretroviral Therapy in Children. J. Infect. Dis., 180:359-368, 1999. PubMed ID: 10395850. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | immunodominance, escape, chronic infection, protective allele |
Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | in vitro stimulation or selection, engineered | |
Experimental methods | Degranulation, CD107a and b cell surface mobilization, In vitro proteasome digestion, Other, Peptide titration | |
Keywords | epitope processing |
Boucau2019 Julie Boucau, Julien Madouasse, Georgio Kourjian, Christopher S. Carlin, Daniel Wambua, Matthew J. Berberich, and Sylvie Le Gall. The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner. J. Immunol., 202(10):2856-2872, 15 May 2019. PubMed ID: 30936293. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172 NL4-3) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | computer prediction | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | vaccine antigen design, viral fitness and reversion |
Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | B*57-KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | computer prediction | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | binding affinity, structure, assay or method development, contact residues |
Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | B57-KF11(p24) | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | OP246: A*01, A*02, B*51, B*57, C*06; P1004: A*02, B*08, B*57, C*06, C*07; AC-43: A*24, A*31, B*14, B*57, C*07, C*08; AC-38: A*01, A*03, B*07, B*57, C*06, C*07; AC-108: A*02, B*57, B*61, C*03, C*06; AC-109: A*01, A*02, B*14, B*57, C*07, C*08 | |
Country | Canada, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | acute/early infection, protective allele |
Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | review, immunodominance, TCR usage, variant cross-reactivity |
Lissina2016 Anna Lissina, Lisa A. Chakrabarti, Masafumi Takiguchi, and Victor Appay. TCR Clonotypes: Molecular Determinants of T-Cell Efficacy against HIV. Curr. Opin. Virol., 16:77-85, Feb 2016. PubMed ID: 26874617. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40 NL4.3) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | In vitro proteasome digestion, Other | |
Keywords | epitope processing |
Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | elite controllers |
Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40 NL4.3) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infected monocyte-derived, HIV-1 infection | |
Country | United States | |
Experimental methods | Chromium-release assay, Other | |
Keywords | epitope processing, dendritic cells |
Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding | |
Keywords | subtype comparisons, escape, viral fitness and reversion, optimal epitope |
Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection, vaccine | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | vaccine-induced immune responses, therapeutic vaccine |
Vaccine type | DNA prime with Ad5 boost |
---|---|
Vaccine strain | A clade, B clade, C clade |
Vaccine component | Env, Gag, Nef, Pol |
Casazza2013 Joseph P. Casazza, Kathryn A. Bowman, Selorm Adzaku, Emily C. Smith, Mary E. Enama, Robert T. Bailer, David A. Price, Emma Gostick, Ingelise J. Gordon, David R. Ambrozak, Martha C. Nason, Mario Roederer, Charla A. Andrews, Frank M. Maldarelli, Ann Wiegand, Mary F. Kearney, Deborah Persaud, Carrie Ziemniak, Raphael Gottardo, Julie E. Ledgerwood, Barney S. Graham, Richard A. Koup, and VRC 101 Study Team. Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire. J. Infect. Dis., 207(12):1829-1840, 15 Jun 2013. PubMed ID: 23482645. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172 NL4-3) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | CTL suppression of replication, In vitro proteasome digestion, Other | |
Keywords | epitope processing, class I down-regulation by Nef, kinetics |
Balamurugan2013 Arumugam Balamurugan, Ayub Ali, Julie Boucau, Sylvie Le Gall, Hwee L. Ng, and Otto O. Yang. HIV-1 Gag Cytotoxic T Lymphocyte Epitopes Vary in Presentation Kinetics Relative to HLA Class I Downregulation. J. Virol., 87(15):8726-8734, Aug 2013. PubMed ID: 23740989. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape |
Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding | |
Keywords | elite controllers |
Ndhlovu2012 Zaza M. Ndhlovu, Jacqueline Proudfoot, Kevin Cesa, Donna Marie Alvino, Ashley McMullen, Seanna Vine, Eleni Stampouloglou, Alicja Piechocka-Trocha, Bruce D. Walker, and Florencia Pereyra. Elite Controllers with Low to Absent Effector CD8+ T Cell Responses Maintain Highly Functional, Broadly Directed Central Memory Responses. J. Virol., 86(12):6959-3969, Jun 2012. PubMed ID: 22514340. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | B*57-KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | Other, Tetramer binding | |
Keywords |
Conrad2012 Joseph A. Conrad, Ramesh K. Ramalingam, Coley B. Duncan, Rita M. Smith, Jie Wei, Louise Barnett, Brenna C. Simons, Shelly L. Lorey, and Spyros A. Kalams. Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance. J. Virol., 86(8):4213-4221, Apr 2012. PubMed ID: 22258246. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CTL suppression of replication | |
Keywords | class I down-regulation by Nef |
Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | Gag-KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, United States | |
Experimental methods | Chromium-release assay | |
Keywords | class I down-regulation by Nef |
Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172 NL4-3) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining | |
Keywords | elite controllers |
Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | B57 KF11 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | in vitro stimulation or selection, HIV-1 infection, vaccine | |
Country | South Africa, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding | |
Keywords | vaccine antigen design |
Vaccine type | adenovirus type 5 (Ad5) |
---|---|
Vaccine strain | B clade, C clade |
Vaccine component | Gag |
Ndhlovu2011 Zaza M. Ndhlovu, Alicja Piechocka-Trocha, Seanna Vine, Ashley McMullen, Kegakilwe C. Koofhethile, Phillip J. R. Goulder, Thumbi Ndung'u, Dan H. Barouch, and Bruce D. Walker. Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells. J. Immunol., 186(12):6914-6924, 15 Jun 2011. PubMed ID: 21576505. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | characterizing CD8+ T cells |
Addo2007 Marylyn M. Addo, Rika Draenert, Almas Rathod, Cori L. Verrill, Benjamin T. Davis, Rajesh T. Gandhi, Gregory K. Robbins, Nesli O. Basgoz, David R. Stone, Daniel E. Cohen, Mary N. Johnston, Theresa Flynn, Alysse G. Wurcel, Eric S. Rosenberg, Marcus Altfeld, and Bruce D. Walker. Fully Differentiated HIV-1 Specific CD8+ T Effector Cells Are More Frequently Detectable in Controlled than in Progressive HIV-1 Infection. PLoS ONE, 2(3):e321, 2007. PubMed ID: 17389912. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | rate of progression, acute/early infection, memory cells |
Sabbaj2007 Steffanie Sabbaj, Sonya L. Heath, Anju Bansal, Sameera Vohra, J Michael Kilby, Allan J. Zajac, and Paul A. Goepfert. Functionally Competent Antigen-Specific CD127(hi) Memory CD8+ T Cells Are Preserved Only in HIV-Infected Individuals Receiving Early Treatment. J. Infect. Dis., 195(1):108-117, 1 Jan 2007. PubMed ID: 17152014. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding | |
Keywords | variant cross-reactivity, characterizing CD8+ T cells |
Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, elite controllers |
Bailey2008 Justin R. Bailey, Karen O'Connell, Hung-Chih Yang, Yefei Han, Jie Xu, Benjamin Jilek, Thomas M. Williams, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Transmission of Human Immunodeficiency Virus Type 1 from a Patient Who Developed AIDS to an Elite Suppressor. J. Virol., 82(15):7395-7410, Aug 2008. PubMed ID: 18495769. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(16-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Canada, South Africa | |
Experimental methods | ||
Keywords | escape |
Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | MM13: A*01, A*01, B*08, B*57, C*06, C*07 | |
Country | United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | dynamics, acute/early infection, optimal epitope |
Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.
Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Barbados, Haiti, Jamaica | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | mother-to-infant transmission, elite controllers |
Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | A1, D | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape |
McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(240-249) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Relative replication capacity assay | |
Keywords | escape, mutation acquisition, elite controllers |
Miura2009a Toshiyuki Miura, Mark A. Brockman, Arne Schneidewind, Michael Lobritz, Florencia Pereyra, Almas Rathod, Brian L. Block, Zabrina L. Brumme, Chanson J. Brumme, Brett Baker, Alissa C. Rothchild, Bin Li, Alicja Trocha, Emily Cutrell, Nicole Frahm, Christian Brander, Ildiko Toth, Eric J. Arts, Todd M. Allen, and Bruce D. Walker. HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition. J Virol, 83(6):2743-2755, Mar 2009. PubMed ID: 19116253. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | in vitro stimulation or selection, HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | TCR usage, assay or method development, chronic infection |
Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | acute/early infection |
Durand2010 Christine M. Durand, Karen A. O'Connell, Linda G. Apuzzo, Susan J. Langan, Hejab Imteyaz, Aima A. Ahonkhai, Christina M. Ceccato, Thomas M. Williams, Joseph B. Margolick, and Joel N. Blankson. HIV-1 Gag Evolution in Recently Infected Human Leukocyte Antigen-B*57 Patients with Low-Level Viremia. AIDS, 24(15):2405-2408, 24 Sep 2010. PubMed ID: 20671542. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining | |
Keywords | elite controllers |
Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF-11 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*57, B*57:01, B*57:03, B*58, B*58:01, B*63) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | (B*57, B*58) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(329-343) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57, B*58:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | B*27, B57; B*27, B*58:01; B*57; B*57; B*57 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, autologous responses, elite controllers |
OConnell2010 Karen A. O'Connell, Timothy P. Brennan, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Control of HIV-1 in Elite Suppressors Despite Ongoing Replication and Evolution in Plasma Virus. J. Virol., 84(14):7018-7028, Jul 2010. PubMed ID: 20444904. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*57, B*58:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Relative replication capacity assay | |
Keywords | responses in children, rate of progression |
Prado2010 Julia G. Prado, Andrew Prendergast, Christina Thobakgale, Claudia Molina, Gareth Tudor-Williams, Thumbi Ndung'u, Bruce D. Walker, and Philip Goulder. Replicative Capacity of Human Immunodeficiency Virus Type 1 Transmitted from Mother to Child Is Associated with Pediatric Disease Progression Rate. J. Virol., 84(1):492-502, Jan 2010. PubMed ID: 19828603. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*57, B*58:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Chopera2008 Denis R. Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P. Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M. Gray, Carolyn Williamson, and CAPRISA 002 Study Team. Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage. PLoS Pathog, 4(3):e1000033, Mar 2008. PubMed ID: 18369479. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*57, B*58:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | immunodominance, characterizing CD8+ T cells |
Mkhwanazi2010 Nompumelelo Mkhwanazi, Christina F. Thobakgale, Mary van der Stok, Shabashini Reddy, Zenele Mncube, Fundisiwe Chonco, Bruce D. Walker, Marcus Altfeld, Philip J. R. Goulder, and Thumbi Ndung'u. Immunodominant HIV-1-Specific HLA-B- and HLA-C-Restricted CD8+ T Cells Do Not Differ in Polyfunctionality. Virology, 405(2):483-491, 30 Sep 2010. PubMed ID: 20638093. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | immunodominance, elite controllers |
Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag( SF2) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KAF | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Kostense2001 S. Kostense, G. S. Ogg, E. H. Manting, G. Gillespie, J. Joling, K. Vandenberghe, E. Z. Veenhof, D. van Baarle, S. Jurriaans, M. R. Klein, and F. Miedema. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur. J. Immunol., 31(3):677-86, Mar 2001. PubMed ID: 11241270. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | vaccine-induced immune responses, characterizing CD8+ T cells |
Vaccine type | canarypox, canarypox prime with recombinant protein boost |
---|---|
Vaccine strain | B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen |
Vaccine component | Gag, gp120, gp41, Nef, Pol, Protease |
Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172 SF2) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | immunodominance, elite controllers |
Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(163-174) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | binding affinity, immunodominance, optimal epitope |
Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | immunodominance, elite controllers |
Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, genital and mucosal immunity |
Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, escape, mutation acquisition, optimal epitope |
Streeck2007a Hendrik Streeck, Mathias Lichterfeld, Galit Alter, Angela Meier, Nickolas Teigen, Bader Yassine-Diab, Harlyn K. Sidhu, Susan Little, Anthony Kelleher, Jean-Pierre Routy, Eric S. Rosenberg, Rafick-Pierre Sekaly, Bruce D. Walker, and Marcus Altfeld. Recognition of a Defined Region within p24 Gag by CD8+ T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles. J. Virol., 81(14):7725-7731, Jul 2007. PubMed ID: 17494064. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Goulder2000a P. J. Goulder, Y. Tang, S. I. Pelton, and B. D. Walker. HLA-B57-Restricted Cytotoxic T-Lymphocyte Activity in a Single Infected Subject toward Two Optimal Epitopes, One of Which Is Entirely Contained Within the Other. J. Virol., 74:5291-5299, 2000. PubMed ID: 10799606. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KAF | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A3, B44, B57, Cw5, Cw6 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection, early-expressed proteins |
Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | Intracellular cytokine staining | |
Keywords | immunodominance, genital and mucosal immunity |
Kaul2003 Rupert Kaul, Paul Thottingal, Joshua Kimani, Peter Kiama, Charles W. Waigwa, Job J. Bwayo, Francis A. Plummer, and Sarah L. Rowland-Jones. Quantitative Ex Vivo Analysis of Functional Virus-Specific CD8 T Lymphocytes in the Blood and Genital Tract of HIV-Infected Women. AIDS, 17(8):1139-1144, May 2003. PubMed ID: 12819514. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(163-174) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A3, B57, C*06, C*07; A*01, A*02:01, B*08, B*57, Cw6, Cw7 | |
Country | United States | |
Experimental methods | Cytokine production, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding | |
Keywords | TCR usage |
Betts2004 Michael R. Betts, David A. Price, Jason M. Brenchley, Karin Loré, F. Javier Guenaga, Anna Smed-Sorensen, David R. Ambrozak, Stephen A. Migueles, Mark Connors, Mario Roederer, Daniel C. Douek, and Richard A. Koup. The Functional Profile of Primary Human Antiviral CD8+ T Cell Effector Activity Is Dictated by Cognate Peptide Concentration. J. Immunol., 172(10):6407-6417, 15 May 2004. PubMed ID: 15128832. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, TCR binding | |
Keywords | rate of progression, TCR usage, optimal epitope |
Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(155-172 B con) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | variant cross-reactivity |
Draenert2004b R. Draenert, C. L. Verrill, Y. Tang, T. M. Allen, A. G. Wurcel, M. Boczanowski, A. Lechner, A. Y. Kim, T. Suscovich, N. V. Brown, M. M. Addo, and B. D. Walker. Persistent Recognition of Autologous Virus by High-Avidity CD8 T Cells in Chronic, Progressive Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(2):630-641, Jan 2004. PubMed ID: 14694094. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HIV exposed persistently seronegative (HEPS) |
Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | immunodominance |
Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | (162-172 B consensus) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | immunodominance, characterizing CD8+ T cells |
Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | characterizing CD8+ T cells |
Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United Kingdom | |
Experimental methods | Intracellular cytokine staining, T-cell Elispot, Tetramer binding | |
Keywords | rate of progression, acute/early infection, characterizing CD8+ T cells |
Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A3, B57, B7, Cw6, Cw7 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 ? | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | South Africa, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | memory cells |
Wherry2006 E John Wherry, Cheryl L. Day, Rika Draenert, Joseph D. Miller, Photini Kiepiela, Tonia Woodberry, Christian Brander, Marylyn Addo, Paul Klenerman, Rafi Ahmed, and Bruce D. Walker. HIV-Specific CD8 T Cells Express Low Levels of IL-7Ralpha: Implications for HIV-Specific T Cell Memory. Virology, 353(2):366-373, 30 Sep 2006. PubMed ID: 16860834. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding | |
Keywords | responses in children, rate of progression |
Chakraborty2005 Rana Chakraborty, Anne-Sophie Morel, Julian K. Sutton, Victor Appay, Ruth M. Ripley, Tao Dong, Tim Rostron, Simon Ogola, Tresa Palakudy, Rachel Musoke, Angelo D'Agostino, Mary Ritter, and Sarah L. Rowland-Jones. Correlates of Delayed Disease Progression in HIV-1-Infected Kenyan Children. J. Immunol., 174(12):8191-8199, 15 Jun 2005. PubMed ID: 15944328. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | computational epitope prediction |
Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172 BRU) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B, CRF02_AG | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | Cote D'Ivoire | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons |
Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KAF | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | binding affinity, rate of progression, escape, characterizing CD8+ T cells |
Jansen2005a Christine A. Jansen, Stefan Kostense, Kristin Vandenberghe, Nening M. Nanlohy, Iris M. De Cuyper, Erwan Piriou, Erik H. Manting, Frank Miedema, and Debbie van Baarle. High Responsiveness of HLA-B57-Restricted Gag-Specific CD8+ T Cells In Vitro May Contribute to the Protective Effect of HLA-B57 in HIV-Infection. Eur. J. Immunol., 35(1):150-158, Jan 2005. PubMed ID: 15593302. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | epitope processing, escape |
Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | Germany, United States | |
Experimental methods | Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | memory cells |
Meyer-Olson2010 Dirk Meyer-Olson, Brenna C. Simons, Joseph A. Conrad, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Coley B. Duncan, Ramesh Ramalingam, and Spyros A. Kalams. Clonal Expansion and TCR-Independent Differentiation Shape the HIV-Specific CD8+ Effector-Memory T-Cell Repertoire In Vivo. Blood, 116(3):396-405, Jul 22 2010. PubMed ID: 20424187. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | B57-KF11(p24) | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | binding affinity, subtype comparisons, acute/early infection |
Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172 SF2, HXBc2/Bal R5) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A1, A2, B40, B57, Cw3, Cw6 | |
Country | United States | |
Experimental methods | Cytokine production, Degranulation, CD107a and b cell surface mobilization, Flow cytometric T-cell cytokine assay | |
Keywords | supervised treatment interruptions (STI), immunodominance, characterizing CD8+ T cells, drug resistance |
Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24( SF2) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons, immunodominance |
Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57, B58) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2002 Rupert Kaul, Sarah L. Rowland-Jones, Geraldine Gillespie, Joshua Kimani, Tao Dong, Peter Kiama, J. Neil Simonsen, Job J. Bwayo, Andrew J. McMichael, and Francis A. Plummer. Gonococcal Cervicitis is Associated with Reduced Systemic CD8+ T Cell Responses in Human Immunodeficiency Virus Type 1-Infected and Exposed, Uninfected Sex Workers. J. Infect. Dis., 185(10):1525-1529, 15 May 2002. PubMed ID: 11992292. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(153-164) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B57, B58) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), immunodominance |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*58:01, B57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | responses in children, mother-to-infant transmission, escape, characterizing CD8+ T cells |
Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ( pMJ5) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*58:01, B57) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | Relative replication capacity assay | |
Keywords | escape, viral fitness and reversion |
Boutwell2009 Christian L Boutwell, Christopher F Rowley, and M Essex. Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein. J Virol, 83(6):2460-8, Mar 2009. PubMed ID: 19109381. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B, C | |
Species (MHC/HLA) | human(B57, B63) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, HLA cross-presentation, optimal epitope, novel epitope |
Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KAF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | rate of progression, escape |
Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | P1: B*57:01; P6: B*57:01 | |
Country | United States | |
Experimental methods | Other | |
Keywords | dynamics, rate of progression, elite controllers |
Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | gag 162-172 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other | |
Keywords | binding affinity, elite controllers |
Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | HLA binding | |
Keywords | binding affinity, NK cells |
Martin2018 Maureen P. Martin, Vivek Naranbhai, Patrick R. Shea, Ying Qi, Veron Ramsuran, Nicolas Vince, Xiaojiang Gao, Rasmi Thomas, Zabrina L. Brumme, Jonathan M. Carlson, Steven M. Wolinsky, James J. Goedert, Bruce D. Walker, Florencia P. Segal, Steven G. Deeks, David W. Haas, Stephen A. Migueles, Mark Connors, Nelson Michael, Jacques Fellay, Emma Gostick, Sian Llewellyn-Lacey, David A. Price, Bernard A. Lafont, Phillip Pymm, Philippa M. Saunders, Jacqueline Widjaja, Shu Cheng Wong, Julian P. Vivian, Jamie Rossjohn, Andrew G. Brooks, and Mary Carrington. Killer Cell Immunoglobulin-Like Receptor 3DL1 Variation Modifies HLA-B*57 Protection against HIV-1. J. Clin. Invest., 128(5):1903-1912, 1 May 2018. PubMed ID: 29461980. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172 LAI) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression |
Goulder1996 P. J. R. Goulder, M. Bunce, P. Krausa, K. McIntyre, S. Crowley, B. Morgan, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Novel, Cross-Restricted, Conserved and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow HIV Type 1 Infection. AIDS Res. Hum. Retroviruses, 12:1691-1698, 1996. HLA-B*57 is over-represented in slow progressors. HLA*5801 is a closely related molecule, and while the defined anchor residues of HLA*5801 can be used to predict epitopes in HIV-1 proteins, the CTL from HLA-B*57 positive individuals have limited cross-presentation capacity with HLA*5801 targets. In this paper five new HLA-B*57 epitopes were defined. PubMed ID: 8959245. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | Tetramer binding | |
Keywords |
Fadda2011 Lena Fadda, Geraldine M. O'Connor, Swati Kumar, Alicja Piechocka-Trocha, Clair M. Gardiner, Mary Carrington, Daniel W. McVicar, and Marcus Altfeld. Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules. J Virol, 85(12):5970-5974, Jun 2011. PubMed ID: 21471246. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, immunodominance |
Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172 NL4-3) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | R039: A*01:01, A*31:01, B*27:05, B*57:01, C*02:02, C*06:02 | |
Country | United Kingdom | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | acute/early infection |
Kloverpris2013 Henrik N. Kløverpris, Rebecca P. Payne, Jonah B. Sacha, Jane T. Rasaiyaah, Fabian Chen, Masafumi Takiguchi, Otto O. Yang, Greg J. Towers, Philip Goulder, and Julia G. Prado. Early Antigen Presentation of Protective HIV-1 KF11Gag and KK10Gag Epitopes from Incoming Viral Particles Facilitates Rapid Recognition of Infected Cells by Specific CD8+ T Cells. J. Virol., 87(5):2628-2638, Mar 2013. PubMed ID: 23255798. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*01:01, A*03:01, B*27:05, B*57:01; A*01:01, A*24:02, B*40:02, B*57:01; A*24:02, A*32:01, B*40:02, B*57:01; A*01:01, A*02:01, B*51:01, B*57:01; A*01:01, A*01:01, B*08:01, B*57:01; A*03:01, A*24:02, B*35:01, B*57:01 | |
Country | United States | |
Experimental methods | Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression |
Norstrom2012 Melissa M. Norström, Marcus Buggert, Johanna Tauriainen, Wendy Hartogensis, Mattia C. Prosperi, Mark A. Wallet, Frederick M. Hecht, Marco Salemi, and Annika C. Karlsson. Combination of Immune and Viral Factors Distinguishes Low-Risk Versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects. J. Virol., 86(18):9802-9816, Sep 2012. PubMed ID: 22761389. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression, immunodominance |
Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | computational epitope prediction, optimal epitope |
ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 21746: A*01:01, A*68:01, B*40:01, B*57:01, C*03:04, C*06:02, DQB1*03:02, DQB1*03:03; 10849: A*23:01, A*68:01, B*35:43, B*57:03, C*01:02, C*02:10; 67200: A*01:01, A*24:02, B*08:01, B*57:01, C*06:02, C*07:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KAF | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding | |
Keywords | rate of progression, TCR usage, variant cross-reactivity |
Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | immunodominance, protective allele |
Gorin2017 Aleksandr M. Gorin, Yushen Du, Franklin Y. Liu, Tian-Hao Zhang, Hwee L. Ng, Christian Hofmann, William G. Cumberland, Ren Sun, and Otto O. Yang. HIV-1 Epitopes Presented by MHC Class I Types Associated with Superior Immune Containment of Viremia Have Highly Constrained Fitness Landscapes. PLoS Pathog, 13(8):e1006541, Aug 2017. PubMed ID: 28787455. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172 LAI) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | peptide-HLA interaction | |
Experimental methods | Tetramer binding | |
Keywords | binding affinity |
Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | ||
Keywords | review, escape |
Kaur2009 G. Kaur and N. Mehra. Genetic Determinants of HIV-1 Infection and Progression to AIDS: Immune Response Genes. Tissue Antigens, 74(5):373-385, Nov 2009. PubMed ID: 19765261. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*57:01, B*57:02, B*57:03) | |
Immunogen | vaccine | |
Experimental methods | Other | |
Keywords | review, vaccine-induced immune responses, vaccine antigen design, protective allele |
Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | review, escape, HLA associated polymorphism |
Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | TCR usage |
Simons2008 Brenna C. Simons, Scott E. VanCompernolle, Rita M. Smith, Jie Wei, Louise Barnett, Shelly L. Lorey, Dirk Meyer-Olson, and Spyros A. Kalams. Despite Biased TRBV Gene Usage against a Dominant HLA B57-Restricted Epitope, TCR Diversity Can Provide Recognition of Circulating Epitope Variants. J. Immunol., 181(7):5137-5146, 1 Oct 2008. PubMed ID: 18802118. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Country | India, South Africa, United Kingdom, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | subtype comparisons, escape, TCR usage, mutation acquisition |
Yu2007a Xu G Yu, Mathias Lichterfeld, Senica Chetty, Katie L. Williams, Stanley K. Mui, Toshiyuki Miura, Nicole Frahm, Margaret E. Feeney, Yanhua Tang, Florencia Pereyra, Montiago X. Labute, Katja Pfafferott, Alisdair Leslie, Hayley Crawford, Rachel Allgaier, William Hildebrand, Richard Kaslow, Christian Brander, Todd M. Allen, Eric S. Rosenberg, Photini Kiepiela, Madhu Vajpayee, Paul A. Goepfert, Marcus Altfeld, Philip J. R. Goulder, and Bruce D Walker. Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes. J. Virol., 81(4):1619-1631, Feb 2007. PubMed ID: 17121793. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay | |
Keywords | subtype comparisons, HLA cross-presentation, variant cross-reactivity |
Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Country | Kenya, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding | |
Keywords | immunodominance, TCR usage, structure, characterizing CD8+ T cells |
Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | ||
Experimental methods | ||
Keywords | review |
Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, escape, HLA associated polymorphism, elite controllers |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | R039: A*01:01, A*31:01, B*27:05, B*57:01, C*02:02, C*06:02; R059: A*01:03, A*68:02, B*35:01, B*57:03, C*05:01, C*07:01; R014: A*30:01, A*33:01, B*42:01, B*57:03, C*17:01, C*18:01; R007: A*24:02, A*80:01, B*07:02, B*58:01, C*02:02, C*03:02; R036: A*02:01, A*68:02, B*14:01, B*58:01, C*03:02, C*08:02; N056: A*02:01, A*02:14, B*15:03, B*18:01, C*02:10, C*04:01; N087: A*03:01, A*30:01, B*57:03, B*58:01, C*06:02, C*18:01; K140: A*03:01, A*68:01, B*57:03, B*58:01, C*03:02, C*07:01; K061: A*03:01, A*66:01, B*57:03, B*58:01, C*03:02, C*18:01; 468: A*02:02, A*68:01, B*57:03, B*58:01, C*06:02, C*07:01 | |
Country | South Africa, United Kingdom | |
Experimental methods | HLA binding | |
Keywords | epitope processing |
Kloverpris2013b Henrik N. Kløverpris, Anette Stryhn, Mikkel Harndahl, Rebecca Payne, Greg J. Towers, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Alasdair Leslie, Soren Buus, and Philip Goulder. HLA-Specific Intracellular Epitope Processing Shapes an Immunodominance Pattern for HLA-B*57 That Is Distinct from HLA-B*58:01. J. Virol., 87(19):10889-10894, Oct 2013. PubMed ID: 23864640. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | B, C | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Country | Barbados, Botswana, Spain, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Relative replication capacity assay, TCR binding | |
Keywords | subtype comparisons, variant cross-reactivity |
Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | review, TCR usage |
Gras2008 Stephanie Gras, Lars Kjer-Nielsen, Scott R. Burrows, James McCluskey, and Jamie Rossjohn. T-Cell Receptor Bias and Immunity. Curr. Opin. Immunol., 20(1):119-125, Feb 2008. PubMed ID: 18207719. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KAFS | |
Subtype | A, B | |
Species (MHC/HLA) | human(B*57:01, B*57:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | subtype comparisons, rate of progression |
Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Country | Ethiopia | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, escape, variant cross-reactivity |
Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KAF-11 | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | peptide-HLA interaction | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | structure |
Stewart-Jones2005 Guillaume B. E. Stewart-Jones, Geraldine Gillespie, Ian M. Overton, Rupert Kaul, Philippe Roche, Andrew J. McMichael, Sarah Rowland-Jones, and E. Yvonne Jones. Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression. J. Immunol., 175(4):2459-2468, 15 Aug 2005. PubMed ID: 16081817. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Country | Botswana, South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | HLA associated polymorphism |
Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | A1 | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | ML1111: A*30:01, A*36:01, B*42:01, B*57:03, C*17:01, C*18:01 | |
Country | Kenya | |
Experimental methods | Other | |
Keywords | assay or method development |
Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(20-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | Gag-KF11; p24-KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 00RCH59: A*34:02, A*74:01, B*08:01, B*57:03, C*03:02, C*07:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay | |
Keywords | HAART, ART |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | Gag-KF11 | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | review, escape, HLA associated polymorphism |
Avila-Rios2019 Santiago Avila-Rios, Jonathan M. Carlson, Mina John, Simon Mallal, and Zabrina L. Brumme. Clinical and Evolutionary Consequences of HIV Adaptation to HLA: Implications for Vaccine and Cure. Curr. Opin. HIV AIDS, 14(3):194-204, May 2019. PubMed ID: 30925534. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172 LAI) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | computational epitope prediction, optimal epitope |
ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Country | Netherlands | |
Experimental methods | ||
Keywords | review, escape |
Kaur2009 G. Kaur and N. Mehra. Genetic Determinants of HIV-1 Infection and Progression to AIDS: Immune Response Genes. Tissue Antigens, 74(5):373-385, Nov 2009. PubMed ID: 19765261. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and reversion, HLA associated polymorphism |
Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(161-171) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*57:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa, Zambia | |
Experimental methods | ||
Keywords | viral fitness and reversion, HLA associated polymorphism |
Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(30-40) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B58) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | B, G | |
Species (MHC/HLA) | human(B58) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A36, B45, B58, Cw3, Cw6; M13371: A*02, A*36, B*45, B*58, C*03, C*06 | |
Country | Nigeria | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons |
Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Subtype | A, B | |
Species (MHC/HLA) | human(B58) | |
Immunogen | HIV-1 infection | |
Country | Sweden | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | subtype comparisons |
Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human(B*58:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, acute/early infection |
Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*63) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(C*01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Species (MHC/HLA) | human(C*14) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24(162-172) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | assay or method development, protective allele |
Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | binding affinity, acute/early infection |
Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | assay or method development, characterizing CD8+ T cells |
Vollbrecht2010 Thomas Vollbrecht, Heike Brackmann, Nadja Henrich, Joerg Roeling, Ulrich Seybold, Johannes R. Bogner, Frank D. Goebel, and Rika Draenert. Impact of Changes in Antigen Level on CD38/PD-1 Co-Expression on HIV-Specific CD8 T Cells in Chronic, Untreated HIV-1 Infection. J. Med. Virol., 82(3):358-370, Mar 2010. PubMed ID: 20087935. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag(162-172 NL4-3) | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | South Africa, Zambia | |
Experimental methods | Other | |
Keywords | escape |
Crawford2009 Hayley Crawford, Wendy Lumm, Alasdair Leslie, Malinda Schaefer, Debrah Boeras, Julia G. Prado, Jianming Tang, Paul Farmer, Thumbi Ndung'u, Shabir Lakhi, Jill Gilmour, Paul Goepfert, Bruce D. Walker, Richard Kaslow, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Evolution of HLA-B*5703 HIV-1 Escape Mutations in HLA-B*5703-Positive Individuals and Their Transmission Recipients. J. Exp. Med., 206(4):909-921, 13 Apr 2009. PubMed ID: 19307327. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | Gag | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Country | Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses, assay or method development, optimal epitope |
Vaccine type | adenovirus type 5 (Ad5) |
---|---|
Vaccine component | Gag, Nef, Pol |
Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | p24 | |
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Gag(162-172) p24(30-40) DNA(1273..1305) |
Gag Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAFSPEVIPMF
|
Epitope Alignment
|
Epitope Name | KF11 | |
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Chromium-release assay, Other | |
Keywords | epitope processing, escape |
Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.