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HIV Molecular Immunology Database

Search CTL/CD8+ T-Cell Epitope Database

Found 10 matching records:

Displaying record number 59885

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HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location Gag(162-169)
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Epitope Name KI8
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54817

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HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location p24(30-37)
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Epitope Name K18
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 2009

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HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Epitope Name Gag-KI8; p24-KI8
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 60637

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HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location p24(30-37)
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Epitope Name KI-8
Subtype B, C
Species (MHC/HLA) human(B*57, B*57:01, B*57:03)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 160

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HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location p24(30-37)
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Epitope Name KI8
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA 026-BMC: A3, B42, B*57:03, C*17, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children

Notes

References

Goulder2000a P. J. Goulder, Y. Tang, S. I. Pelton, and B. D. Walker. HLA-B57-Restricted Cytotoxic T-Lymphocyte Activity in a Single Infected Subject toward Two Optimal Epitopes, One of Which Is Entirely Contained Within the Other. J. Virol., 74:5291-5299, 2000. PubMed ID: 10799606. Show all entries for this paper.


Displaying record number 58285

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HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location Gag(162-169)
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Subtype A1
Species (MHC/HLA) human(B*57:03)
Immunogen HIV-1 infection
Patient MHC/HLA ML1111: A*30:01, A*36:01, B*42:01, B*57:03, C*17:01, C*18:01
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 161

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HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location p24(162-170 LAI)
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Subtype B
Species (MHC/HLA) human(B*57:03)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57441

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HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location Gag
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Epitope Name KAF-8
Species (MHC/HLA) human(B*57:03)
Immunogen peptide-HLA interaction
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords structure

Notes

References

Stewart-Jones2005 Guillaume B. E. Stewart-Jones, Geraldine Gillespie, Ian M. Overton, Rupert Kaul, Philippe Roche, Andrew J. McMichael, Sarah Rowland-Jones, and E. Yvonne Jones. Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression. J. Immunol., 175(4):2459-2468, 15 Aug 2005. PubMed ID: 16081817. Show all entries for this paper.


Displaying record number 62731

Download this epitope record as JSON.

HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location p24
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Epitope Name B57-KI8
Species (MHC/HLA) human
Immunogen in vitro stimulation or selection
Experimental methods In vitro proteasome digestion
Keywords epitope processing

Notes

References

Boucau2019 Julie Boucau, Julien Madouasse, Georgio Kourjian, Christopher S. Carlin, Daniel Wambua, Matthew J. Berberich, and Sylvie Le Gall. The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner. J. Immunol., 202(10):2856-2872, 15 May 2019. PubMed ID: 30936293. Show all entries for this paper.


Displaying record number 62790

Download this epitope record as JSON.

HXB2 Location Gag(162-169)
p24(30-37)
DNA(1273..1296)
Gag Epitope Map
Author Location p24(162-169)
Epitope KAFSPEVI Epitope Alignment
KAFSPEVI epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen engineered
Experimental methods Other, Relative replication capacity assay
Keywords assay or method development, protective allele

Notes

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


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