HIV molecular immunology database
Found 13 matching records:
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(82-91) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Epitope Name | KL10 | |
Species (MHC/HLA) | human(A*11) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(82-91) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Epitope Name | KL10 | |
Species (MHC/HLA) | human(B*57) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(82-91) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Epitope Name | KL10 | |
Species (MHC/HLA) | human(C*03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(82-91) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Epitope Name | KL10 | |
Species (MHC/HLA) | human(C*08) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(82-91 HXB2) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(C*08) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 15160: A*03, A*32, B*14, B*44 | |
Country | United States | |
Experimental methods | Chromium-release assay | |
Keywords | autologous responses, novel epitope |
Harrer1996b T. Harrer, E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. Cytotoxic T Lymphocytes in Asymptomatic Long-Term Nonprogressing HIV-1 Infection. Breadth and Specificity of the Response and Relation to In Vivo Viral Quasispecies in a Person with Prolonged Infection and Low Viral Load. J. Immunol., 156:2616-2623, 1996. PubMed ID: 8786327. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(82-91 LAI) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(C*08:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART |
Nixon1999 D. F. Nixon, D. Douek, P. J. Kuebler, X. Jin, M. Vesanen, S. Bonhoeffer, Y. Cao, R. A. Koup, D. D. Ho, and M. Markowitz. Molecular Tracking of an Human Immunodeficiency Virus Nef Specific Cytotoxic T Cell Clone Shows Persistence of Clone-Specific T Cell Receptor DNA but not mRNA Following Early Combination Antiretroviral Therapy. Immunol. Lett., 66:219-228, 1999. PubMed ID: 10203058. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding | |
Keywords | binding affinity, immunodominance, optimal epitope |
Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | supertype, HLA cross-presentation |
Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | ||
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Epitope Name | KL10 | |
Species (MHC/HLA) | human(Cw8) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Epitope Name | KL10 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A28, A29, B14, B44, Cw8 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | ( B consensus) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Epitope Name | KL10 | |
Subtype | B | |
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A25, A32, B14, B8, Cw7, Cw8 | |
Country | United States | |
Experimental methods | Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords | assay or method development, memory cells, characterizing CD8+ T cells |
Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef( SF2) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Nef(82-91) DNA(9040..9069) |
Nef Epitope Map |
---|---|---|
Author Location | Nef(82-91 SF2) | |
Epitope |
KAAVDLSHFL
|
Epitope Alignment
|
Species (MHC/HLA) | human(Cw8) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, acute/early infection |
Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.