Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 52939

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HXB2 Location	Nef(82-91) DNA(9040..9069)	Nef Epitope Map
Author Location	Nef(82-91)
Epitope	KAALDLSHFL	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords	vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Notes

• After injection of an anti-HIV-1 lipopeptide vaccine and the booster injections, a response was observed in >85% of 28 volunteers, and a long-term immune response was observed in >50% of the volunteers. A positive effect of QS21 adjuvant was found for B-and CD4+T-cell responses. A higher number of CD8+ T-cell epitopes was induced after a fourth boost injection. This epitope was one of 31 that the vaccinated volunteers responded to.
• A KAAvDLSHFL variant was cross-recognized after the last boost.

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.

Displaying record number 59211

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HXB2 Location	Nef(82-91) DNA(9040..9069)	Nef Epitope Map
Author Location	Nef(82-91)
Epitope	KAALDLSHFL	Epitope Alignment
		Show epitope variants
Epitope Name	KL10
Subtype	B
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	P2: B*57:01; P3: B*57:01; P4: B*57:01; P6: B*57:01
Country	United States
Experimental methods	Other
Keywords	dynamics, rate of progression, elite controllers

Notes

• Variations at 4 Gag and 2 Nef epitopes in 6 B*5701+ ART-naive males from the Options cohort - 3 high-risk progressors (HRPs) and 3 very low-risk progressors (LRPs) - were tested for correlation to polyfunctional T cell responses. Subjects were followed from infection to 7 years post-infection and 6 markers (IFN-γ, IL-2, MIP-1β, TNF, CD107a and perforin) were measured. While LRPs maintained a directed functional response against emerging variants, emerging epitopes in HRPs correlated with a decrease in IL-2-producing cells, functional avidity and polyfunctional sensitivity.
• Variants (KAALDLSHlL, KgALDLSHFL, rAALDLSHFL, KAAvDLSHFL, rAAvDLSHFL, rAALDLSHlL) of KAALDLSHFL, KL10, were seen in 2/3 HRPs and 2/3 LRPs, over 3 time points.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.