HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 16 matching records:

Displaying record number 53263

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef( C consensus)
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Subtype C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, viral fitness and reversion

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 53831

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef(82-90)
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, A*66, B*4201, B*5802, Cw*0602, Cw*1701; A*66, A*68, B*57, B*5802, Cw*0602, Cw*0701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 56603

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef(82-90)
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Epitope Name KF9
Subtype C
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 58635

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef(82-90)
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Show epitope variants
Epitope Name KF9
Subtype C
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords subtype comparisons, computational epitope prediction, mother-to-infant transmission, escape, viral fitness and reversion, optimal epitope

Notes

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


Displaying record number 54290

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Epitope Name KF9
Subtype C
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Country Botswana, Ethiopia, South Africa, Tanzania
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Bhattacharya2007 Tanmoy Bhattacharya, Marcus Daniels, David Heckerman, Brian Foley, Nicole Frahm, Carl Kadie, Jonathan Carlson, Karina Yusim, Ben McMahon, Brian Gaschen, Simon Mallal, James I. Mullins, David C. Nickle, Joshua Herbeck, Christine Rousseau, Gerald H. Learn, Toshiyuki Miura, Christian Brander, Bruce Walker, and Bette Korber. Founder Effects in the Assessment of HIV Polymorphisms and HLA Allele Associations. Science, 315(5818):1583-1586, 16 Mar 2007. PubMed ID: 17363674. Show all entries for this paper.


Displaying record number 61671

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef(82-90)
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Epitope Name KF9
Species (MHC/HLA) human(B*5701)
Immunogen peptide-HLA interaction
Experimental methods Other, Tetramer binding
Keywords structure, NK cells, protective allele

Notes

References

OConnor2015 Geraldine M. O'Connor, Julian P. Vivian, Emma Gostick, Phillip Pymm, Bernard A. P. Lafont, David A. Price, Jamie Rossjohn, Andrew G. Brooks, and Daniel W. McVicar. Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1. J. Virol., 89(10):5213-5221, May 2015. PubMed ID: 25740999. Show all entries for this paper.


Displaying record number 56224

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location  
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Subtype C
Species (MHC/HLA) human(B*5701, B*5801)
Immunogen HIV-1 infection
Patient MHC/HLA A*0301, A*2301, B*1503, B*5802, Cw*0210, Cw*0602
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 58821

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef(81-89)
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Epitope Name KF9 Nef
Subtype C
Species (MHC/HLA) human(B*5702, B*5703, B*5801)
Immunogen HIV-1 infection
Country Botswana, South Africa, Zimbabwe
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords optimal epitope, HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.


Displaying record number 61217

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Show epitope variants
Epitope Name KF9
Subtype B
Species (MHC/HLA) human(B*5702, B*5703, B*5801)
Immunogen HIV-1 infection
Experimental methods Other
Keywords review, escape, HLA associated polymorphism

Notes

References

Kloverpris2015a Henrik N. Kløverpris, Alasdair Leslie, and Philip Goulder. Role of HLA Adaptation in HIV Evolution. Front. Immunol., 6:665, 18 Jan 2016. PubMed ID: 26834742. Show all entries for this paper.


Displaying record number 58648

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location  
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Species (MHC/HLA) human(B*5703)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 62133

HXB2 Location Nef(82-90) Nef Epitope Map
Author Location Nef(88-90)
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Show epitope variants
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods Other, Relative replication capacity assay
Keywords escape

Notes

References

Barton2019 John P. Barton, Erasha Rajkoomar, Jaclyn K. Mann, Dariusz K. Murakowski, Mako Toyoda, Macdonald Mahiti, Phillip Mwimanzi, Takamasa Ueno, Arup K. Chakraborty, and Thumbi Ndung'u. Modelling and in vitro testing of the HIV-1 Nef fitness landscape. Virus Evol, 5(2):vez029 doi, Jul 2019. PubMed ID: 31392033 Show all entries for this paper.


Displaying record number 57753

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Subtype C
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.


Displaying record number 57874

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Show epitope variants
Epitope Name KF9
Subtype C
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, acute/early infection

Notes

References

Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.


Displaying record number 58649

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location  
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Species (MHC/HLA) human(B*5801)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 56482

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Subtype C
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 61092

HXB2 Location Nef(82-90)
DNA(9040..9066)
Nef Epitope Map
Author Location Nef(82-90)
Epitope KAAFDLSFF Epitope Alignment
KAAFDLSFF epitope logo
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CH198: A*0301, A*7401, B*0801, B*57, Cw*0701, Cw*0702
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

References

Barton2016 John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, and Arup K. Chakraborty. Relative Rate and Location of Intra-Host HIV Evolution to Evade Cellular Immunity Are Predictable. Nat. Commun., 7:11660, 23 May 2016. PubMed ID: 27212475. Show all entries for this paper.


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