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Displaying record number 55881

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HXB2 Location	Gag(261-272) p24(129-140) DNA(1570..1605)	Gag Epitope Map
Author Location	Gag
Epitope	IYKRWIILGLNK	Epitope Alignment
Subtype	A, B, C, CRF01_AE
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A24-restricted epitope IYKRWIILGLNK is from subtype A,B and C peptide libraries, and is reactive in subtype B and subtype AE-carrying subjects. This epitope is part of reacting peptide IYKRWIILGLNKIVR.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.