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Displaying record number 55582

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HXB2 Location	Gag(261-269) p24(129-137) DNA(1570..1596)	Gag Epitope Map
Author Location	Gag(263-272 NL-432 or NL-M20A)
Epitope	IYKRWIILG	Epitope Alignment
Epitope Name	Gag263-10
Subtype	B
Species (MHC/HLA)	human(A*24:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*24:02
Country	Japan
Experimental methods	CTL suppression of replication, Chromium-release assay, HLA binding
Keywords

Notes

• To clarify mechanisms of escape mutation accumulation in the population, the Japanese Nef138-10 (RYPLTFGWCF) epitope was studied amongst hemophiliacs and others, to determine replication suppression abilities of both the wild type and 2F (RfPLTFGWCF) mutant virus. This mutant is conserved due to reduced CTL suppression of viral replication, also preventing viral reversion to WT upon transfer to a new host.
• Epitope Gag263-10, IYKRWIILG, was used as a comparison for positive cytolytic activity of epitope-specific HLA-A*2402 clones against target cells prepulsed with corresponding peptide. These clones partially suppressed NL-M20A viral replication.

References

Fujiwara2008 Mamoru Fujiwara, Junko Tanuma, Hirokazu Koizumi, Yuka Kawashima, Kazutaka Honda, Saori Mastuoka-Aizawa, Sachi Dohki, Shinichi Oka, and Masafumi Takiguchi. Different Abilities of Escape Mutant-Specific Cytotoxic T Cells to Suppress Replication of Escape Mutant and Wild-Type Human Immunodeficiency Virus Type 1 in New Hosts. J. Virol., 82(1):138-147, Jan 2008. PubMed ID: 17959671. Show all entries for this paper.