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Displaying record number 63029

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HXB2 Location	Pol(775-783) Integrase(60-68)	Pol Epitope Map
Author Location	( SUMA)
Epitope	IWQLDCTHL	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	SUMA: A*11:03, A*24:02, B*14:02, B*15:01, C*08:02, C*12:03
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	dynamics, acute/early infection, autologous responses

Notes

• Yang2019 developed mathematical models with the Jones2004 dataset & concluded that, in general, relative CTL response breadth increased moderately during the first symptomatic month and then remained relatively stable through the first 400 days post-infection. Analysis also suggested slow expansion kinetics for most HIV-specific CTL responses and the presence of intra- and interclonal competition.
• The patient SUMA maintained low viral loads and stable CD4 T cell counts through seven years of follow up. In contrast to more rapid progressors, WEAU and BORI, SUMA had a broader response, with little immunodominance.
• The dynamics of a IWQLDCTHL-specific CTL response in patient SUMA are shown in Fig. S1 of Yang2019 but this response was not published in Jones2004.
• Autologous patient SUMA epitopes IWQLDCTHL & THLEGKVIL overlap.

References

Jones2004 Nicola A. Jones, Xiping Wei, Darren R. Flower, MaiLee Wong, Franziska Michor, Michael S. Saag, Beatrice H. Hahn, Martin A. Nowak, George M. Shaw, and Persephone Borrow. Determinants of Human Immunodeficiency Virus Type 1 Escape from the Primary CD8+ Cytotoxic T Lymphocyte Response. J. Exp. Med., 200(10):1243-1256, 15 Nov 2004. PubMed ID: 15545352. Show all entries for this paper.

Yang2019 Yiding Yang, and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8(+) T-Cell Responses in Acute Infection. Microorganisms, 7(3):microorganisms7030069 doi, Mar 2019. PubMed ID: 30836625 Show all entries for this paper.