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Displaying record number 1410

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HXB2 Location	Pol(400-407) RT(245-252) DNA(3282..3305)	Pol Epitope Map
Author Location	Pol
Epitope	IVPEKDSW	Epitope Alignment
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• HLA tetramers to six epitopes were used to study HLA-A2, B8 and B57 CTL in 54 patients -- HIV-specific tetramer positive cells were inversely correlated with viral load in patients with high CD4, but in patients with CD4 T-cells below 400 high tetramer frequencies were found despite high viral load.
• Most patients have high levels of HIV-specific T-cell expansions, but many of these cells aren't functional.
• In 15 of the patients, the proportion of IFN gamma producing tetramer cells correlated with AIDS-free survival.

References

Kostense2001 S. Kostense, G. S. Ogg, E. H. Manting, G. Gillespie, J. Joling, K. Vandenberghe, E. Z. Veenhof, D. van Baarle, S. Jurriaans, M. R. Klein, and F. Miedema. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur. J. Immunol., 31(3):677-86, Mar 2001. PubMed ID: 11241270. Show all entries for this paper.