HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 34 matching records:

Displaying record number 59865

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol(399-407)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*3501, B*3508)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59866

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol(399-407)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54872

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location  
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 52204

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords early-expressed proteins, kinetics

Notes

References

Guillon2002a Christophe Guillon, Carel A. van Baalen, Patrick H. M. Boers, Esther J. Verschuren, Rob A. Gruters, and Albert D. M. E. Osterhaus. Construction and Characterisation of Infectious Recombinant HIV-1 Clones Containing CTL Epitopes from Structural Proteins in Nef. J Virol Methods, 99(1-2):115-121, Jan 2002. PubMed ID: 11684309. Show all entries for this paper.


Displaying record number 52352

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252 ACH320.2A.2.1)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Subtype B
Species (MHC/HLA) (B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection, early-expressed proteins, kinetics

Notes

References

vanBaalen2002 Carel A. van Baalen, Christophe Guillon, Minus van Baalen, Esther J. Verschuren, Patrick H. M. Boers, Albert D. M. E. Osterhaus, and Rob A. Gruters. Impact of Antigen Expression Kinetics on the Effectiveness of HIV-Specific Cytotoxic T Lymphocytes. Eur. J. Immunol., 32(9):2644-2652, Sep 2002. PubMed ID: 12207349. Show all entries for this paper.


Displaying record number 53491

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 54390

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name B57-IW9(RT)
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55109

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Gag
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, mutation acquisition, optimal epitope

Notes

References

Streeck2007a Hendrik Streeck, Mathias Lichterfeld, Galit Alter, Angela Meier, Nickolas Teigen, Bader Yassine-Diab, Harlyn K. Sidhu, Susan Little, Anthony Kelleher, Jean-Pierre Routy, Eric S. Rosenberg, Rafick-Pierre Sekaly, Bruce D. Walker, and Marcus Altfeld. Recognition of a Defined Region within p24 Gag by CD8+ T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles. J. Virol., 81(14):7725-7731, Jul 2007. PubMed ID: 17494064. Show all entries for this paper.


Displaying record number 55202

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location  
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 55612

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 488

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(399-407)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B57)
Immunogen  
Experimental methods  
Keywords  

References

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 57951

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IVW9
Subtype A1, B, C
Species (MHC/HLA) human(B57, B58)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus
Vaccine strain B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component Env, Gag-Pol

Notes

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.


Displaying record number 53645

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location  
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords responses in children, mother-to-infant transmission, escape

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 57423

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location  
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Show epitope variants
Epitope Name IVW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


Displaying record number 55345

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location  
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 59863

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol(399-407)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59144

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Show epitope variants
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 56395

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, variant cross-reactivity, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 57329

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Subtype A, CRF02_AG, CRF06_cpx, CRF09_cpx
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Burkina Faso
Experimental methods Other
Keywords drug resistance

Notes

References

Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.


Displaying record number 57399

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol(399-407)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 61565

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name B57-IW9(RT)
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA OP246: A*01, A*02, B*51, B*57, Cw*06; AC-43: A*24, A*31, B*14, B*57, Cw*07, Cw*08; AC-38: A*01, A*03, B*07, B*57, Cw*06, Cw*07; AC-108: A*02, B*57, B*61, Cw*03, Cw*06; AC-109: A*01, A*02, B*14, B*57, Cw*07, Cw*08
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords acute/early infection, protective allele

Notes

References

Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.


Displaying record number 54826

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name rtIW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 54380

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location  
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 57591

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IVW9
Subtype B
Species (MHC/HLA) (B*57, B*58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 485

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT( LAI)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 489

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(399-407)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57915

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location  
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords  

Notes

References

Fadda2011 Lena Fadda, Geraldine M. O'Connor, Swati Kumar, Alicja Piechocka-Trocha, Clair M. Gardiner, Mary Carrington, Daniel W. McVicar, and Marcus Altfeld. Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules. J Virol, 85(12):5970-5974, Jun 2011. PubMed ID: 21471246. Show all entries for this paper.


Displaying record number 58989

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 60962

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA 21746: A*0101, A*4801, B*4001, B*5701, Cw*0304, Cw*0602; 67200: A*0101, A*2401, B*0801, B*5701, Cw*0602, Cw*0701; 44091: A*0201, A*2401, B*4401, B*5701, Cw*0501, Cw*6002
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61578

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(162-172)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B*5701, B*5702, B*5703)
Immunogen vaccine
Experimental methods Other
Keywords review, vaccine-induced immune responses, vaccine antigen design, protective allele

Notes

References

Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.


Displaying record number 487

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location RT(244-252 LAI)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*5701, B*5801)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, rate of progression, escape

Notes

References

Klein1998 M. R. Klein, S. H. van der Burg, E. Hovenkamp, A. M. Holwerda, J. W. Drijfhout, C. J. Melief, and F. Miedema. Characterization of HLA-B57-Restricted Human Immunodeficiency Virus Type 1 Gag- and RT-Specific Cytotoxic T Lymphocyte Responses. J. Gen. Virol., 79(Pt 9):2191-2201, 1998. PubMed ID: 9747728. Show all entries for this paper.


Displaying record number 1709

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol(244-252)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.


Displaying record number 59864

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol(399-407)
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58071

HXB2 Location Pol(399-407)
RT(244-252)
DNA(3279..3305)
Pol Epitope Map
Author Location Pol
Epitope IVLPEKDSW Epitope Alignment
IVLPEKDSW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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