HIV molecular immunology database
Found 18 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Protease(71-79 LAI) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*68:02, A*74:01, A19) | |
Immunogen | ||
Experimental methods | ||
Keywords | subtype comparisons |
Dong1998 T. Dong. Personal Communication, 1998. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Pol 59 | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Country | Denmark | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining | |
Keywords |
Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.
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HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(59-) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | Pol59 | |
Species (MHC/HLA) | transgenic mouse(A2) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | binding affinity, subtype comparisons, computational epitope prediction |
Vaccine type | peptide |
---|---|
Vaccine component | Protease |
Adjuvant | Incomplete Freund's Adjuvant (IFA) |
Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.
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HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(60-68) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A28) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A28, A29, B14, B44, Cw8 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(59-65) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Species (MHC/HLA) | human(A28) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | RT(71-79 LAI) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | P2 | |
Subtype | B | |
Species (MHC/HLA) | human(A28 supertype) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HAART, ART, supertype |
Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Protease | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | IV9(Protease) | |
Subtype | B | |
Species (MHC/HLA) | human(A68) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Subtype | A, B, C, D | |
Species (MHC/HLA) | human(A*68:02) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | RT(71-79 subtype A, B, D) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Subtype | A, B, D | |
Species (MHC/HLA) | human(A*68:02) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Species (MHC/HLA) | human(A74) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | RT(71-79 subtype A, B, D) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Subtype | A, B, D | |
Species (MHC/HLA) | human(A*74:01) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol-Protease(58-67) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | IV9 | |
Subtype | C | |
Species (MHC/HLA) | human(A*74:01) | |
Immunogen | HIV-1 infection | |
Country | Botswana, Malawi, South Africa, Zimbabwe | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, HLA binding | |
Keywords | binding affinity |
Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.
Matthews2011 Philippa C. Matthews, Emily Adland, Jennifer Listgarten, Alasdair Leslie, Nompumelelo Mkhwanazi, Jonathan M. Carlson, Mikkel Harndahl, Anette Stryhn, Rebecca P. Payne, Anthony Ogwu, Kuan-Hsiang Gary Huang, John Frater, Paolo Paioni, Henrik Kloverpris, Pieter Jooste, Dominique Goedhals, Cloete van Vuuren, Dewald Steyn, Lynn Riddell, Fabian Chen, Graz Luzzi, Thambiah Balachandran, Thumbi Ndung'u, Søren Buus, Mary Carrington, Roger Shapiro, David Heckerman, and Philip J. R. Goulder. HLA-A*7401-Mediated Control of HIV Viremia Is Independent of Its Linkage Disequilibrium with HLA-B*5703. J. Immunol., 186(10):5675-5686, 15 May 2011. PubMed ID: 21498667. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(59-67) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | IV9 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(59-67) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | IV9 | |
Species (MHC/HLA) | human(B*40) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(59-67) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | IV9 | |
Species (MHC/HLA) | human(C*04) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(59-67) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | IV9 | |
Species (MHC/HLA) | human(C*15) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(59-67) | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Epitope Name | IV9 | |
Species (MHC/HLA) | human(C*17) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(59-67) Protease(3-11) DNA(2259..2285) |
Pol Epitope Map |
---|---|---|
Author Location | Protease | |
Epitope |
ITLWQRPLV
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | Mexico, Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | drug resistance |
Blanco-Heredia2016 Juan Blanco-Heredia, Aarón Lecanda, Humberto Valenzuela-Ponce, Christian Brander, Santiago Ávila-Rios, and Gustavo Reyes-Terán. Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naive HIV-Infected Individuals. PLoS One, 11(1):e0147571, 2016. PubMed ID: 26808823. Show all entries for this paper.