HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 397

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Protease(71-79 LAI)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Subtype B
Species (MHC/HLA) human(A*6802, A*7401, A19)
Immunogen  
Experimental methods  
Keywords subtype comparisons

Notes

References

Dong1998 T. Dong. Personal Communication, 1998. Show all entries for this paper.


Displaying record number 55374

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location  
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Show epitope variants
Epitope Name Pol 59
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords  

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 52682

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol(59-)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name Pol59
Species (MHC/HLA) transgenic mouse(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords binding affinity, subtype comparisons, computational epitope prediction

Vaccine Details

Vaccine type peptide
Vaccine component Protease
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 53570

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol(60-68)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Subtype B
Species (MHC/HLA) human(A28)
Immunogen HIV-1 infection
Patient MHC/HLA A28, A29, B14, B44, Cw8
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 1432

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol(59-65)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Species (MHC/HLA) human(A28)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 1499

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location RT(71-79 LAI)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name P2
Subtype B
Species (MHC/HLA) human(A28 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supertype

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 55967

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Protease
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name IV9(Protease)
Subtype B
Species (MHC/HLA) human(A68)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 52429

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human(A*6802)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 1138

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location RT(71-79 subtype A, B, D)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Subtype A, B, D
Species (MHC/HLA) human(A*6802)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1667

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Species (MHC/HLA) human(A74)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1140

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location RT(71-79 subtype A, B, D)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Subtype A, B, D
Species (MHC/HLA) human(A*7401)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58299

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol-Protease(58-67)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name IV9
Subtype C
Species (MHC/HLA) human(A*7401)
Immunogen HIV-1 infection
Country Botswana, Malawi, South Africa, Zimbabwe
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, HLA binding
Keywords binding affinity

Notes

References

Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.

Matthews2011 Philippa C. Matthews, Emily Adland, Jennifer Listgarten, Alasdair Leslie, Nompumelelo Mkhwanazi, Jonathan M. Carlson, Mikkel Harndahl, Anette Stryhn, Rebecca P. Payne, Anthony Ogwu, Kuan-Hsiang Gary Huang, John Frater, Paolo Paioni, Henrik Kloverpris, Pieter Jooste, Dominique Goedhals, Cloete van Vuuren, Dewald Steyn, Lynn Riddell, Fabian Chen, Graz Luzzi, Thambiah Balachandran, Thumbi Ndung'u, Søren Buus, Mary Carrington, Roger Shapiro, David Heckerman, and Philip J. R. Goulder. HLA-A*7401-Mediated Control of HIV Viremia Is Independent of Its Linkage Disequilibrium with HLA-B*5703. J. Immunol., 186(10):5675-5686, 15 May 2011. PubMed ID: 21498667. Show all entries for this paper.


Displaying record number 59858

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol(59-67)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59860

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol(59-67)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59861

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol(59-67)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(C*04)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59859

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol(59-67)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(C*15)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59862

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Pol(59-67)
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(C*17)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61263

HXB2 Location Pol(59-67)
Protease(3-11)
DNA(2259..2285)
Pol Epitope Map
Author Location Protease
Epitope ITLWQRPLV Epitope Alignment
ITLWQRPLV epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Mexico, Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords drug resistance

Notes

References

Blanco-Heredia2016 Juan Blanco-Heredia, Aarón Lecanda, Humberto Valenzuela-Ponce, Christian Brander, Santiago Ávila-Rios, and Gustavo Reyes-Terán. Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naive HIV-Infected Individuals. PLoS One, 11(1):e0147571, 2016. PubMed ID: 26808823. Show all entries for this paper.


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