HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 90 matching records:

Displaying record number 56371

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*15, B*57)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, viral fitness and reversion, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 59844

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1296

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag( SF2)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Goulder2001 P. J. Goulder, M. M. Addo, M. A. Altfeld, E. S. Rosenberg, Y. Tang, U. Govender, N. Mngqundaniso, K. Annamalai, T. U. Vogel, M. Hammond, M. Bunce, H. M. Coovadia, and B. D. Walker. Rapid Definition of Five Novel HLA-A*3002-Restricted Human Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Epitopes by Elispot and Intracellular Cytokine Staining Assays. J. Virol., 75(3):1339-1347, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1339. PubMed ID: 11152507. Show all entries for this paper.


Displaying record number 1381

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISP
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 1460

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 1556

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155 SF2)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 57973

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance, elite controllers

Notes

References

Akinsiku2011 Olusimidele T. Akinsiku, Anju Bansal, Steffanie Sabbaj, Sonya L. Heath, and Paul A. Goepfert. Interleukin-2 Production by Polyfunctional HIV-1-Specific CD8 T Cells Is Associated with Enhanced Viral Suppression. J. Acquir. Immune Defic. Syndr., 58(2):132-140, 1 Oct 2011. PubMed ID: 21637109. Show all entries for this paper.


Displaying record number 53832

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, A*66, B*4201, B*5802, Cw*0602, Cw*1701; A*66, A*68, B*57, B*5802, Cw*0602, Cw*0701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 54534

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, subtype comparisons, acute/early infection

Notes

References

Malhotra2007 Uma Malhotra, Jessica Nolin, James I. Mullins, and M. Juliana McElrath. Comprehensive Epitope Analysis of Cross-Clade Gag-Specific T-Cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic. Vaccine, 25(2):381-390, 4 Jan 2007. PubMed ID: 17112643. Show all entries for this paper.


Displaying record number 53218

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, epitope processing, escape

Notes

References

Goulder2004 Philip J R Goulder and David I Watkins. HIV and SIV CTL Escape: Implications for Vaccine Design. Nat. Rev. Immunol., 4(8):630-640, Aug 2004. PubMed ID: 15286729. Show all entries for this paper.


Displaying record number 54870

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 53512

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, epitope processing, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53636

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name IW9
Subtype C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Ethiopia
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords immunodominance, escape, variant cross-reactivity

Notes

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.


Displaying record number 54670

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HAART, ART, escape, viral fitness and reversion

Notes

References

Asquith2006 Becca Asquith, Charles T. T. Edwards, Marc Lipsitch, and Angela R. McLean. Inefficient Cytotoxic T Lymphocyte-Mediated Killing of HIV-1-Infected Cells In Vivo. PLoS Biol., 4(4):e90, Apr 2006. PubMed ID: 16515366. Show all entries for this paper.


Displaying record number 52326

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISP
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 52753

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A28, A3, B53, B57; A31, B57, B7
Experimental methods Chromium-release assay
Keywords TCR usage, genital and mucosal immunity

Notes

References

Musey2003 L. Musey, Y. Ding, J. Cao, J. Lee, C. Galloway, A. Yuen, K. R. Jerome, and M. J. McElrath. Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8+ Cytotoxic T Lymphocytes. J. Virol., 77(1):291-300, Jan 2003. PubMed ID: 12477834. Show all entries for this paper.


Displaying record number 55609

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 52917

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISW9
Subtype B, C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords epitope processing, escape

Notes

References

Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.


Displaying record number 140

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 53204

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location (147-155 B consensus)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords characterizing CD8+ T cells

Notes

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.


Displaying record number 57340

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), immunodominance

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 54598

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(144-152)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Subtype A, C
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 infection
Country Tanzania
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, immunodominance

Notes

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 56750

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location ( pMJ4)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype C
Species (MHC/HLA) human(B*5801, B57)
Immunogen in vitro stimulation or selection
Experimental methods Relative replication capacity assay
Keywords escape, viral fitness and reversion

Notes

References

Boutwell2009 Christian L Boutwell, Christopher F Rowley, and M Essex. Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein. J Virol, 83(6):2460-8, Mar 2009. PubMed ID: 19109381. Show all entries for this paper.


Displaying record number 53648

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISW9
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords epitope processing, responses in children, mother-to-infant transmission, escape

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 139

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155 IIIB)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression

Notes

References

Goulder1996 P. J. R. Goulder, M. Bunce, P. Krausa, K. McIntyre, S. Crowley, B. Morgan, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Novel, Cross-Restricted, Conserved and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow HIV Type 1 Infection. AIDS Res. Hum. Retroviruses, 12:1691-1698, 1996. HLA-B*57 is over-represented in slow progressors. HLA*5801 is a closely related molecule, and while the defined anchor residues of HLA*5801 can be used to predict epitopes in HIV-1 proteins, the CTL from HLA-B*57 positive individuals have limited cross-presentation capacity with HLA*5801 targets. In this paper five new HLA-B*57 epitopes were defined. PubMed ID: 8959245. Show all entries for this paper.


Displaying record number 62125

HXB2 Location Gag(147-155)
p24(15-23)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name B*57-IW9
Species (MHC/HLA) human(B*57)
Immunogen computer prediction
Country Argentina
Experimental methods Other, Relative replication capacity assay
Keywords binding affinity, structure, assay or method development, contact residues

Notes

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.


Displaying record number 53122

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 54245

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 54576

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 54816

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords immunodominance, TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 55218

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA A*310102, A*6603, B*440302, B*570301, Cw*040101, Cw*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords escape, viral fitness and reversion, drug resistance, elite controllers

Notes

References

Bailey2007 Justin R. Bailey, Haili Zhang, Barbara W. Wegweiser, Hung-Chih Yang, Laura Herrera, Aima Ahonkhai, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Evolution of HIV-1 in an HLA-B*57-Positive Patient during Virologic Escape. J. Infect. Dis., 196(1):50-55, 1 Jul 2007. PubMed ID: 17538883. Show all entries for this paper.


Displaying record number 56153

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Canada
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008a Zabrina L. Brumme, Iris Tao, Sharon Szeto, Chanson J. Brumme, Jonathan M. Carlson, Dennison Chan, Carl Kadie, Nicole Frahm, Christian Brander, Bruce Walker, David Heckerman, and P Richard Harrigan. Human Leukocyte Antigen-Specific Polymorphisms in HIV-1 Gag and Their Association with Viral Load in Chronic Untreated Infection. AIDS, 22(11):1277-1286, 11 Jul 2008. PubMed ID: 18580606. Show all entries for this paper.


Displaying record number 56871

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL neutralization assay, Chromium-release assay
Keywords epitope processing, elite controllers, neutralization by CTL

Notes

References

Chen2009a Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, and Bruce D. Walker. Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes. J. Virol., 83(7):3138-3149, Apr 2009. PubMed ID: 19158248. Show all entries for this paper.


Displaying record number 57131

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) (B*57)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining, Relative replication capacity assay
Keywords escape, HLA associated polymorphism

Notes

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.


Displaying record number 57245

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 57258

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name IW9
Subtype A1, D
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape

Notes

References

McKinnon2009 Lyle R. McKinnon, Rupert Capina, Harold Peters, Mark Mendoza, Joshua Kimani, Charles Wachihi, Anthony Kariri, Makobu Kimani, Meika Richmond, Sandy Koesters Kiazyk, Keith R. Fowke, Walter Jaoko, Ma Luo, T Blake Ball, and Francis A. Plummer. Clade-Specific Evolution Mediated by HLA-B*57/5801 in Human Immunodeficiency Virus Type 1 Clade A1 p24. J Virol, 83(23):12636-12642, Dec 2009. PubMed ID: 19759140. Show all entries for this paper.


Displaying record number 57391

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 57415

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization
Keywords elite controllers

Notes

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


Displaying record number 57649

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods Relative replication capacity assay
Keywords escape, acute/early infection, HLA associated polymorphism, elite controllers

Notes

References

Miura2010 Toshiyuki Miura, Zabrina L. Brumme, Mark A. Brockman, Pamela Rosato, Jennifer Sela, Chanson J. Brumme, Florencia Pereyra, Daniel E. Kaufmann, Alicja Trocha, Brian L. Block, Eric S. Daar, Elizabeth Connick, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, Martin Markowitz, Kim Schafer, Florin Vaida, Aikichi Iwamoto, Susan Little, and Bruce D. Walker. Impaired Replication Capacity of Acute/Early Viruses in Persons Who Become HIV Controllers. J. Virol., 84(15):7581-7591, Aug 2010. PubMed ID: 20504921. Show all entries for this paper.


Displaying record number 58283

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Conrad2011 Joseph A. Conrad, Ramesh K. Ramalingam, Rita M. Smith, Louise Barnett, Shelly L. Lorey, Jie Wei, Brenna C. Simons, Shanmugalakshmi Sadagopal, Dirk Meyer-Olson, and Spyros A. Kalams. Dominant Clonotypes within HIV-Specific T Cell Responses Are Programmed Death-1 High and CD127 Low and Display Reduced Variant Cross-Reactivity. J. Immunol., 186(12):6871-6885, 15 Jun 2011. PubMed ID: 21562156. Show all entries for this paper.


Displaying record number 58365

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name B57 IW9
Subtype B, C
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection, vaccine
Country South Africa, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine antigen design

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine strain B clade, C clade
Vaccine component Gag

Notes

References

Ndhlovu2011 Zaza M. Ndhlovu, Alicja Piechocka-Trocha, Seanna Vine, Ashley McMullen, Kegakilwe C. Koofhethile, Phillip J. R. Goulder, Thumbi Ndung'u, Dan H. Barouch, and Bruce D. Walker. Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells. J. Immunol., 186(12):6914-6924, 15 Jun 2011. PubMed ID: 21576505. Show all entries for this paper.


Displaying record number 58505

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 58637

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


Displaying record number 58743

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag( NL4-3)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining
Keywords elite controllers

Notes

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58772

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name Gag-IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 58858

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name B57-ISW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Canada
Experimental methods Chromium-release assay, Other
Keywords epitope processing, escape

Notes

References

Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.


Displaying record number 59133

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23 NL4.3)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infected monocyte-derived, HIV-1 infection
Country United States
Experimental methods Chromium-release assay, Other
Keywords epitope processing, dendritic cells

Notes

References

Dinter2014 Jens Dinter, Pauline Gourdain, Nicole Y. Lai, Ellen Duong, Edith Bracho-Sanchez, Marijana Rucevic, Paul H. Liebesny, Yang Xu, Mariko Shimada, Musie Ghebremichael, Daniel G. Kavanagh, and Sylvie Le Gall. Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition. J. Immunol., 193(9):4322-4334, 1 Nov 2014. PubMed ID: 25230751. Show all entries for this paper.


Displaying record number 59137

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 59186

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23 NL4.3)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Other
Keywords epitope processing

Notes

References

Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.


Displaying record number 59293

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 59843

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61280

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(146-155 NL4-3)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords epitope processing

Notes

References

Rucevic2016 Marijana Rucevic, Georgio Kourjian, Julie Boucau, Renata Blatnik, Wilfredo Garcia Bertran, Matthew J. Berberich, Bruce D. Walker, Angelika B. Riemer, and Sylvie Le Gall. Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses. J. Virol., 90(19):8605-8620, 1 Oct 2016. PubMed ID: 27440904. Show all entries for this paper.


Displaying record number 61561

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name B57-IW9(p24)
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA MS: A*02, A*31, B*51, B*57; P1004: A*02, B*08, B*57, Cw*06, Cw*07; AC-38: A*01, A*03, B*07, B*57, Cw*06, Cw*07; AC-109: A*01, A*02, B*14, B*57, Cw*07, Cw*08
Country Canada, Germany, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords acute/early infection, protective allele

Notes

References

Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.


Displaying record number 60628

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW-9
Subtype B, C
Species (MHC/HLA) human(B*57, B*5701, B*63, Cw*0602)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 2012

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name Gag-IW9; p24-IW9
Subtype B
Species (MHC/HLA) human(B*57, B*58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 57590

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Subtype B
Species (MHC/HLA) (B*57, B*58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 57189

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Patient MHC/HLA B*27, B*57; B*27, B*5801; B*57; B*57; B*57
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, autologous responses, elite controllers

Notes

References

OConnell2010 Karen A. O'Connell, Timothy P. Brennan, Justin R. Bailey, Stuart C. Ray, Robert F. Siliciano, and Joel N. Blankson. Control of HIV-1 in Elite Suppressors Despite Ongoing Replication and Evolution in Plasma Virus. J. Virol., 84(14):7018-7028, Jul 2010. PubMed ID: 20444904. Show all entries for this paper.


Displaying record number 57684

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Subtype C
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords immunodominance, characterizing CD8+ T cells

Notes

References

Mkhwanazi2010 Nompumelelo Mkhwanazi, Christina F. Thobakgale, Mary van der Stok, Shabashini Reddy, Zenele Mncube, Fundisiwe Chonco, Bruce D. Walker, Marcus Altfeld, Philip J. R. Goulder, and Thumbi Ndung'u. Immunodominant HIV-1-Specific HLA-B- and HLA-C-Restricted CD8+ T Cells Do Not Differ in Polyfunctionality. Virology, 405(2):483-491, 30 Sep 2010. PubMed ID: 20638093. Show all entries for this paper.


Displaying record number 55664

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Subtype C
Species (MHC/HLA) human(B*57, B*5801)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, viral fitness and reversion, compensatory mutation

Notes

References

Chopera2008 Denis R. Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P. Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M. Gray, Carolyn Williamson, and CAPRISA 002 Study Team. Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage. PLoS Pathog, 4(3):e1000033, Mar 2008. PubMed ID: 18369479. Show all entries for this paper.


Displaying record number 59164

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name gag 147-155
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 57912

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords  

Notes

References

Fadda2011 Lena Fadda, Geraldine M. O'Connor, Swati Kumar, Alicja Piechocka-Trocha, Clair M. Gardiner, Mary Carrington, Daniel W. McVicar, and Marcus Altfeld. Common HIV-1 Peptide Variants Mediate Differential Binding of KIR3DL1 to HLA-Bw4 Molecules. J Virol, 85(12):5970-5974, Jun 2011. PubMed ID: 21471246. Show all entries for this paper.


Displaying record number 58232

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*2301, B*1402, B*5701, Cw*0701, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 59207

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA P1: B*5701; P3: B*5701; P4: B*5701; P5: B*5701; P6: B*5701
Country United States
Experimental methods Other
Keywords elite controllers

Notes

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 141

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155 IIIB)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 54744

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen peptide-HLA interaction
Experimental methods Tetramer binding
Keywords binding affinity

Notes

References

Gillespie2007 Geraldine M. A. Gillespie, Arman Bashirova, Tao Dong, Daniel W. McVicar, Sarah L. Rowland-Jones, and Mary Carrington. Lack of KIR3DS1 Binding to MHC Class I Bw4 Tetramers in Complex with CD8+ T Cell Epitopes. AIDS Res. Hum. Retroviruses, 23(3):451-455, Mar 2007. PubMed ID: 17411378. Show all entries for this paper.


Displaying record number 55002

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISP
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 52758

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, escape

Notes

References

Migueles2003 Stephen A. Migueles, Alisha C. Laborico, Hiromi Imamichi, W. Lesley Shupert, Cassandra Royce, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Claire W. Hallahan, and Mark Connors. The Differential Ability of HLA B*5701+ Long-Term Nonprogressors and Progressors to Restrict Human Immunodeficiency Virus Replication Is Not Caused by Loss of Recognition of Autologous Viral gag Sequences. J. Virol., 77(12):6889-6898, Jun 2003. PubMed ID: 12768008. Show all entries for this paper.


Displaying record number 56630

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(140-157)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name IW9
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0205, B*5301, B*5701, Cw*0401, Cw*1801
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords escape, acute/early infection

Notes

References

Goonetilleke2009 Nilu Goonetilleke, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, Gerald H. Learn, Emma L. Turnbull, Maria G Salazar, Kent J Weinhold, Stephen Moore, CHAVI Clinical Core B, Norman Letvin, Barton F. Haynes, Myron S. Cohen, Peter Hraber, Tanmoy Bhattacharya, Persephone Borrow, Alan S. Perelson, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, and Andrew J. McMichael. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med., 206(6):1253-1272, 8 Jun 2009. PubMed ID: 19487423. Show all entries for this paper.


Displaying record number 52085

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 58812

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*2705, B*5701; A*0101, A*2402, B*4002, B*5701; A*2402, A*3201, B*4002, B*5701; A*0101, A*0201, B*5101, B*5701; A*0101, A*0101, B*0801, B*5701; A*0301, A*2402, B*3501, B*5701
Country United States
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression

Notes

References

Norstrom2012 Melissa M. Norström, Marcus Buggert, Johanna Tauriainen, Wendy Hartogensis, Mattia C. Prosperi, Mark A. Wallet, Frederick M. Hecht, Marco Salemi, and Annika C. Karlsson. Combination of Immune and Viral Factors Distinguishes Low-Risk Versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects. J. Virol., 86(18):9802-9816, Sep 2012. PubMed ID: 22761389. Show all entries for this paper.


Displaying record number 60959

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA 21746: A*0101, A*4801, B*4001, B*5701, Cw*0304, Cw*0602; 10849: A*2301, A*6801, B*3543, B*5703, Cw*0102, Cw*0210
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 52081

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Migueles2001 Stephen A. Migueles and Mark Connors. Frequency and Function of HIV-Specific CD8(+) T Cells. Immunol. Lett., 79(1-2):141-150, 1 Nov 2001. PubMed ID: 11595301. Show all entries for this paper.


Displaying record number 61577

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B*5701, B*5702, B*5703, B*5801)
Immunogen vaccine
Experimental methods Other
Keywords review, vaccine-induced immune responses, vaccine antigen design, protective allele

Notes

References

Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.


Displaying record number 58674

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISW9
Subtype C
Species (MHC/HLA) human(B*5701, B*5702, B*5703, B*5801)
Immunogen HIV-1 infection
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords HLA associated polymorphism

Notes

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.


Displaying record number 142

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155 LAI)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701, B*5801)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression

Notes

References

Klein1998 M. R. Klein, S. H. van der Burg, E. Hovenkamp, A. M. Holwerda, J. W. Drijfhout, C. J. Melief, and F. Miedema. Characterization of HLA-B57-Restricted Human Immunodeficiency Virus Type 1 Gag- and RT-Specific Cytotoxic T Lymphocyte Responses. J. Gen. Virol., 79(Pt 9):2191-2201, 1998. PubMed ID: 9747728. Show all entries for this paper.


Displaying record number 58794

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B*5702)
Immunogen  
Experimental methods  
Keywords review

Notes

References

Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.


Displaying record number 61629

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Epitope Name ISW9
Subtype B
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country Barbados, Botswana, Spain, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Relative replication capacity assay, TCR binding
Keywords subtype comparisons, variant cross-reactivity

Notes

References

Payne2014 R. P. Payne, S. Branch, H Kløverpris, P. C. Matthews, C. K. Koofhethile, T. Strong, E. Adland, E. Leitman, J. Frater, T. Ndung'u, E. Hunter, R. Haubrich, B. Mothe, A. Edwards, L. Riddell, F. Chen, P. R. Harrigan, Z. L. Brumme, S. Mallal, M. John, J. P. Jooste, R. Shapiro, S. G. Deeks, B. D. Walker, C. Brander, C. Landis, J. M. Carlson, J. G. Prado, and P. J. R. Goulder. Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints. J. Virol., 88(9):4668-4678, May 2014. PubMed ID: 24501417. Show all entries for this paper.


Displaying record number 57847

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords acute/early infection, NK cells

Notes

References

Brackenridge2011 Simon Brackenridge, Edward J. Evans, Mireille Toebes, Nilu Goonetilleke, Michael K. P. Liu, Kati di Gleria, Ton N. Schumacher, Simon J. Davis, Andrew J. McMichael, and Geraldine M. Gillespie. An Early HIV Mutation within an HLA-B*57-Restricted T Cell Epitope Abrogates Binding to the Killer Inhibitory Receptor 3DL1. J. Virol., 85(11):5415-5422, Jun 2011. PubMed ID: 21430058. Show all entries for this paper.


Displaying record number 56588

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype C
Species (MHC/HLA) human(B*5703)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 57439

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISP
Species (MHC/HLA) human(B*5703)
Immunogen peptide-HLA interaction
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords structure

Notes

References

Stewart-Jones2005 Guillaume B. E. Stewart-Jones, Geraldine Gillespie, Ian M. Overton, Rupert Kaul, Philippe Roche, Andrew J. McMichael, Sarah Rowland-Jones, and E. Yvonne Jones. Structures of Three HIV-1 HLA-B*5703-Peptide Complexes and Identification of Related HLAs Potentially Associated with Long-Term Nonprogression. J. Immunol., 175(4):2459-2468, 15 Aug 2005. PubMed ID: 16081817. Show all entries for this paper.


Displaying record number 53675

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Show epitope variants
Subtype B, D
Species (MHC/HLA) human(B58)
Immunogen HIV-1 infection
Patient MHC/HLA A23, A24, B35, B58, Cw4, Cw7
Country Democratic Republic of the Congo
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, variant cross-reactivity

Notes

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 54136

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location  
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human(B*63)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59845

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(C*12)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53510

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human(Cw*0602)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 56343

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Subtype B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Canada, South Africa
Experimental methods  
Keywords escape

Notes

References

Carlson2008 Jonathan M. Carlson, Zabrina L. Brumme, Christine M. Rousseau, Chanson J. Brumme, Philippa Matthews, Carl Kadie, James I. Mullins, Bruce D. Walker, P. Richard Harrigan, Philip J. R. Goulder, and David Heckerman. Phylogenetic Dependency Networks: Inferring Patterns of CTL Escape and Codon Covariation in HIV-1 Gag. PLoS Comput Biol, 4(11):e1000225, Nov 2008. PubMed ID: 19023406. Show all entries for this paper.


Displaying record number 56732

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag(147-155)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name ISW9
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods Other
Keywords escape

Notes

References

Crawford2009 Hayley Crawford, Wendy Lumm, Alasdair Leslie, Malinda Schaefer, Debrah Boeras, Julia G. Prado, Jianming Tang, Paul Farmer, Thumbi Ndung'u, Shabir Lakhi, Jill Gilmour, Paul Goepfert, Bruce D. Walker, Richard Kaslow, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Evolution of HLA-B*5703 HIV-1 Escape Mutations in HLA-B*5703-Positive Individuals and Their Transmission Recipients. J. Exp. Med., 206(4):909-921, 13 Apr 2009. PubMed ID: 19307327. Show all entries for this paper.


Displaying record number 61060

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location p24(15-23)
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CH058: A*0101, A*2301, B*1402, B*57, Cw*0701, Cw*0802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

References

Barton2016 John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, and Arup K. Chakraborty. Relative Rate and Location of Intra-Host HIV Evolution to Evade Cellular Immunity Are Predictable. Nat. Commun., 7:11660, 23 May 2016. PubMed ID: 27212475. Show all entries for this paper.


Displaying record number 61343

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Australia, Brazil, Canada, Dominican Republic, Haiti, Jamaica, Peru, Puerto Rico, United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, assay or method development, optimal epitope

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine component Gag, Nef, Pol

Notes

References

Fiore-Gartland2016 Andrew Fiore-Gartland, Bryce A. Manso, David P. Friedrich, Erin E. Gabriel, Greg Finak, Zoe Moodie, Tomer Hertz, Stephen C. De Rosa, Nicole Frahm, Peter B. Gilbert, and M Juliana McElrath. Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials. PLoS One, 11(2):e0147812, 2016. PubMed ID: 26863315. Show all entries for this paper.


Displaying record number 56974

HXB2 Location Gag(147-155)
p24(15-23)
DNA(1228..1254)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Subtype A1
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 62168

HXB2 Location Gag(240-249)
p24(108-117)
Gag Epitope Map
Author Location Gag
Epitope ISPRTLNAW Epitope Alignment
ISPRTLNAW epitope logo
Epitope Name IW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Carlson2015 Jonathan M. Carlson, Anh Q. Le, Aniqa Shahid, and Zabrina L. Brumme. HIV-1 adaptation to HLA: a window into virus-host immune interactions. Trends Microbiol, 23(4):212-24 doi, Apr 2015. PubMed ID: 25613992 Show all entries for this paper.


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