Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 1728

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HXB2 Location	gp160(109-117) gp120(109-117) DNA(6549..6575)	gp160 Epitope Map
Author Location	Env(109-117 CM243 subtype CRF01)
Epitope	ISLWDQSLK	Epitope Alignment
Epitope Name	E109-117
Subtype	CRF01_AE
Species (MHC/HLA)	human(A*11)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• This was a study of HIV-1 exposed persistently seronegative (HEPS) female sex workers in Chiang Mai, northern Thailand.
• HLA-A*11 is very common in this population, and was enriched among the HEPS sexworkers -- weak CTL responses were detected in 4/7 HEPS women, and CTL responses were found in 8/8 HIV+ controls, and 0/9 HIV- women that were not exposed.
• This epitope was weakly reactive in the HEPS study subject 265 who was HLA A*02/A*11, and had been predicted to be a possible A*11 epitope using Epimer in Bond2001

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.

Displaying record number 55132

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HXB2 Location	gp160(109-117) gp120(109-117) DNA(6549..6575)	gp160 Epitope Map
Author Location	gp120(109-117)
Epitope	ISLWDQSLK	Epitope Alignment
Species (MHC/HLA)	human(A11)
Immunogen
Experimental methods
Keywords	subtype comparisons, viral fitness and reversion

Notes

• Determined the frequencies of known CD8+ and CD4+ Env epitope sequences among Brazilian HIV sequences of various subtypes.
• Present in 48/51 Brazilian HIV sequences.

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.