HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 53088

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location RT Pol(55-63)
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Species (MHC/HLA) human(A*01)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 59838

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location Rev(55-63)
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Epitope Name IY9
Species (MHC/HLA) human(A*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62000

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location Rev(55-63)
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Species (MHC/HLA) human(A*01:01)
Immunogen peptide-HLA interaction
Experimental methods Intracellular cytokine staining, Other
Keywords assay or method development, NK cells

Notes

References

Partridge2018 Thomas Partridge, Annalisa Nicastri, Anna E. Kliszczak, Louis-Marie Yindom, Benedikt M. Kessler, Nicola Ternette, and Persephone Borrow. Discrimination Between Human Leukocyte Antigen Class I-Bound and Co-Purified HIV-Derived Peptides in Immunopeptidomics Workflows. Front. Immunol., 9:912, 2018. PubMed ID: 29780384. Show all entries for this paper.


Displaying record number 53824

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location Rev
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*01:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*01:01, A*03:01, B*08:01, B*51:01; A*01:01, B*08:01
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords escape, acute/early infection, characterizing CD8+ T cells

Notes

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 618

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location Rev(55-63 LAI)
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Subtype B
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression

Notes

References

vanBaalen1997 C. A. van Baalen, O. Pontesilli, R. C. Huisman, A. M. Geretti, M. R. Klein, F. de Wolf, F Miedema, R. A. Gruters, and A. D. M. E. Osterhaus. Human Immunodeficiency Virus Type 1 Rev- and Tat-Specific Cytotoxic T Lymphocyte Frequencies Inversely Correlate with Rapid Progression to AIDS. J. Gen. Virol., 78:1913-1918, 1997. CTLp frequencies to Rev and Tat were inversely correlated with rapid progression to AIDS, but not Gag, RT or Nef. 3/7 long term non-progressors and 0/5 progressors were positive for HLA-B57, so it was again found to be associated with long term survival. PubMed ID: 9266987. Show all entries for this paper.


Displaying record number 1647

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location Rev(55-63)
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Species (MHC/HLA) human(A1)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 54218

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location Rev
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Epitope Name A1-IY9(Rev)
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 59837

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location Rev(55-63)
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Epitope Name IY9
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62763

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HXB2 Location Rev(55-63)
DNA(8465..8491)
Rev Epitope Map
Author Location Rev( JR-CSF)
Epitope ISERILSTY Epitope Alignment
ISERILSTY epitope logo
Show epitope variants
Epitope Name IY9
Subtype B
Species (MHC/HLA) humanized mouse
Immunogen HIV-1 infection, vaccine, virus
Experimental methods Cytokine production, IVAG challenge, Other, T-cell Elispot
Keywords vaccine-induced immune responses, escape, assay or method development

Vaccine Details

Vaccine type virus, PLG microparticle, recombinant protein
Vaccine strain B clade
Vaccine component Gag, virus

Notes

References

Claiborne2019 Daniel T. Claiborne, Timothy E. Dudek, Colby R. Maldini, Karen A. Power, Musie Ghebremichael, Edward Seung, Elizabeth F. Mellors, Vladimir D. Vrbanac, Katharine Krupp, Abigail Bisesi, Andrew M. Tager, David M. Knipe, Christian L. Boutwell, and Todd M. Allen. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. J. Virol., 93(20), 15 Oct 2019. PubMed ID: 31375576. Show all entries for this paper.


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