Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 61761

HXB2 Location	Vif(18-27) DNA(5092..5121)	Vif Epitope Map
Author Location	Vif(18-27)
Epitope	IRTWKSLVKH	Epitope Alignment
Epitope Name	IH10
Species (MHC/HLA)	human(B*2705)
Immunogen
Experimental methods
Keywords	optimal epitope

Notes

• C. Brander notes this as an B*2705-restricted Vif epitope (Borthwick2017).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 61834

HXB2 Location	Vif(18-27) DNA(5092..5121)	Vif Epitope Map
Author Location
Epitope	IRTWKSLVKH	Epitope Alignment
Epitope Name	IH10
Species (MHC/HLA)	human(B*2705)
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	VID418: A*0201, A*2402, B*0702, B*2705, Cw*0102, Cw*0702
Country	United Kingdom
Experimental methods	Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, novel epitope

Notes

• Since CTL response in natural HIV-1 infections is mostly against variable but immunodominant epitopes, lymphocytes from 12 vaccine(HIVconsv)-exposed subjects of the HIV-CORE 002 study were used to determine and define 14 less variable but typically subdominant, optimal novel epitopes.
• Epitope IRTWKSLVKH (IH10) is within peptide MRIRTWKSLVKHHLT (HC103) that was recognized by VID418, 1/12 vaccinated subjects. IH10 is an HLA-B*2705-restricted novel, optimal epitope which is a candidate for the Los Alamos Immunology database A-list.

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.