Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 61760

HXB2 Location	Vif(18-26) DNA(5092..5118)	Vif Epitope Map
Author Location	Vif(18-26)
Epitope	`IRTWKSLVK`	Epitope Alignment
Epitope Name	IK9
Species (MHC/HLA)	human(A*3001)
Immunogen
Experimental methods
Keywords	optimal epitope

Notes

C. Brander notes this as an A*3001-restricted Vif epitope (Borthwick2017).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 61832

HXB2 Location	Vif(18-26) DNA(5092..5118)	Vif Epitope Map
Author Location
Epitope	`IRTWKSLVK`	Epitope Alignment
Epitope Name	IK9
Species (MHC/HLA)	human(A*3001)
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	VID403: A0101, A3001, B1302, B3901, Cw0602, Cw0701
Country	United Kingdom
Experimental methods	Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, novel epitope

Notes

Since CTL response in natural HIV-1 infections is mostly against variable but immunodominant epitopes, lymphocytes from 12 vaccine(HIVconsv)-exposed subjects of the HIV-CORE 002 study were used to determine and define 14 less variable but typically subdominant, optimal novel epitopes.
Epitope IRTWKSLVK (IK9) is within peptide KQVDRMRIRTWKSLVK (HC102) that was recognized by VID403, 1/12 vaccinated subjects. IK9 is an HLA-A*3001-restricted novel epitope which is a candidate for the Los Alamos Immunology database A-list.

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.