Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 61760

Download this epitope record as JSON.

HXB2 Location	Vif(18-26) DNA(5092..5118)	Vif Epitope Map
Author Location	Vif(18-26)
Epitope	IRTWKSLVK	Epitope Alignment
Epitope Name	IK9
Species (MHC/HLA)	human(A*30:01)
Immunogen
Experimental methods
Keywords	optimal epitope, A-list

Notes

• C. Brander notes this as an A*3001-restricted Vif epitope (Borthwick2017).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 61832

Download this epitope record as JSON.

HXB2 Location	Vif(18-26) DNA(5092..5118)	Vif Epitope Map
Author Location
Epitope	IRTWKSLVK	Epitope Alignment
Epitope Name	IK9
Species (MHC/HLA)	human(A*30:01)
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	VID403: A*01:01, A*30:01, B*13:02, B*39:01, C*06:02, C*07:01, DQB1*02, DQB1*05, DRB1*07:01, DRB1*16:01, DRB4, DRB5
Country	United Kingdom
Experimental methods	Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, novel epitope

Notes

• Since CTL response in natural HIV-1 infections is mostly against variable but immunodominant epitopes, lymphocytes from 12 vaccine(HIVconsv)-exposed subjects of the HIV-CORE 002 study were used to determine and define 14 less variable but typically subdominant, optimal novel epitopes.
• Epitope IRTWKSLVK (IK9) is within peptide KQVDRMRIRTWKSLVK (HC102) that was recognized by VID403, 1/12 vaccinated subjects. IK9 is an HLA-A*3001-restricted novel epitope which is a candidate for the Los Alamos Immunology database A-list.

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.