HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 22 matching records:

Displaying record number 59827

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59829

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59831

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Species (MHC/HLA) human(A*6802)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1819

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Show epitope variants
Epitope Name IK9
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance, escape

Notes

References

Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.


Displaying record number 52933

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Patient MHC/HLA A26, B27
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, rate of progression, immunodominance, escape

Notes

References

Feeney2004 M. E. Feeney, Y. Tang, K. A. Roosevelt, A. J. Leslie, K. McIntosh, N. Karthas, B. D. Walker, and P. J. R. Goulder. Immune Escape Precedes Breakthrough Human Immunodeficiency Virus Type 1 Viremia and Broadening of the Cytotoxic T-Lymphocyte Response in an HLA-B27-Positive Long-Term-Nonprogressing Child. J. Virol., 78(16):8927-8930, Aug 2004. PubMed ID: 15280502. Show all entries for this paper.


Displaying record number 53629

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Show epitope variants
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B35, B8
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HAART, ART, escape, variant cross-reactivity

Notes

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


Displaying record number 55488

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Subtype B
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords superinfection

Notes

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.


Displaying record number 15

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27 LAI)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) human(B27)
Immunogen  
Experimental methods  
Keywords  

References

Brander1996 Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Systematic Identification of Optimal Epitopes. pages IV--50--IV--60. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1996. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.


Displaying record number 16

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27 JRCSF)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) scid-hu mouse(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape

Notes

References

McKinney1999 D. McKinney, D. Lewinson, S. Riddell, P. Greenberg, and D. Mosier. The Antiviral Activity of HIV-Specific CD8+ CTL Clones Is Limited by Elimination Due to Encounter with HIV-Infected Targets. J. Immunol., 163:861-867, 1999. PubMed ID: 10395680. Show all entries for this paper.


Displaying record number 1161

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17( SF2)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 57785

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK-9
Species (MHC/HLA) human(B27)
Immunogen in vitro stimulation or selection
Experimental methods Cytotoxicity assay
Keywords dendritic cells

Notes

References

Aldy2011 Kim N. Aldy, Nathan C. Horton, Porunelloor A. Mathew, and Stephen O. Mathew. 2B4+ CD8+ T Cells Play an Inhibitory Role against Constrained HIV Epitopes. Biochem. Biophys. Res. Commun., 405(3):503-507, 18 Feb 2011. PubMed ID: 21256826. Show all entries for this paper.


Displaying record number 59830

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57822

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) human(B*27)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression, escape, TCR usage

Notes

References

Ammaranond2011 Palanee Ammaranond, David J. van Bockel, Kathy Petoumenos, Marylin McMurchie, Robert Finlayson, Melanie G. Middleton, Miles P. Davenport, Vanessa Venturi, Kazuo Suzuki, Linda Gelgor, John M. Kaldor, David A. Cooper, and Anthony D. Kelleher. HIV Immune Escape at an Immunodominant Epitope in HLA-B*27-Positive Individuals Predicts Viral Load Outcome. J. Immunol., 186(1):479-488, 1 Jan 2011. PubMed ID: 21115730. Show all entries for this paper.


Displaying record number 60958

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Patient MHC/HLA 79379: A*0101, A*0101, B*2705, B*5201, Cw*0201, Cw*1202
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 55036

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location  
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 17

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27 JRCSF)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57771

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location p17(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Subtype B
Species (MHC/HLA) human(B*2705)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Other
Keywords rate of progression

Notes

References

Payne2010 Rebecca P. Payne, Henrik Kløverpris, Jonah B. Sacha, Zabrina Brumme, Chanson Brumme, Søren Buus, Stuart Sims, Stephen Hickling, Lynn Riddell, Fabian Chen, Graz Luzzi, Anne Edwards, Rodney Phillips, Julia G. Prado, and Philip J. R. Goulder. Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B*2705-Restricted CD8+ T Cells. J. Virol., 84(20):10543-10557, Oct 2010. PubMed ID: 20686036. Show all entries for this paper.


Displaying record number 59828

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59833

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Species (MHC/HLA) human(B*82)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59832

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag(19-27)
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Epitope Name IK9
Species (MHC/HLA) human(C*12)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58015

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location Gag
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*03, A*03, B*1402, B*3501, Cw*0401, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 54948

HXB2 Location Gag(19-27)
p17(19-27)
DNA(844..870)
Gag Epitope Map
Author Location  
Epitope IRLRPGGKK Epitope Alignment
IRLRPGGKK epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A3, A33; B15 (63), B27
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox prime with gp120 boost
Vaccine strain other
Vaccine component gp160

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


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