HIV molecular immunology database
Found 13 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(850-858) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Epitope Name | IY9 | |
Species (MHC/HLA) | human(A*34) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Epitope Name | IY9(Integrase) | |
Subtype | B | |
Species (MHC/HLA) | human(B15) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | enhancing activity, non-susceptible form, chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(850-858) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Epitope Name | IY9 | |
Species (MHC/HLA) | human(B*15:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | subtype comparisons, rate of progression, immunodominance |
Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa, United Kingdom | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | computational epitope prediction, optimal epitope |
ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(850-858) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Epitope Name | IY9-Int | |
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding | |
Keywords | TCR usage, characterizing CD8+ T cells |
Kloverpris2014a Henrik N. Kløverpris, Reuben McGregor, James E McLaren, Kristin Ladell, Anette Stryhn, Catherine Koofhethile, Jacqui Brener, Fabian Chen, Lynn Riddell, Luzzi Graziano, Paul Klenerman, Alasdair Leslie, Søren Buus, David A. Price, and Philip Goulder. Programmed Death-1 Expression on HIV-1-Specific CD8+ T Cells Is Shaped by Epitope Specificity, T-Cell Receptor Clonotype Usage and Antigen Load. AIDS, 28(14):2007-2021, 10 Sep 2014. PubMed ID: 24906112. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | ||
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(135-143) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Experimental methods | Other | |
Keywords | HLA associated polymorphism |
Boutwell2007 Christian L. Boutwell and M. Essex. Identification of HLA Class I-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses, 23(1):165-174, Jan 2007. PubMed ID: 17263647. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(135-143) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Epitope Name | IY9 | |
Subtype | A1, D | |
Species (MHC/HLA) | human(B*15:03) | |
Immunogen | HIV-1 infection | |
Country | Uganda | |
Experimental methods | HLA binding, Relative replication capacity assay | |
Keywords | subtype comparisons, escape, HLA associated polymorphism |
Kinloch2019 Natalie N. Kinloch, Guinevere Q. Lee, Jonathan M. Carlson, Steven W. Jin, Chanson J. Brumme, Helen Byakwaga, Conrad Muzoora, Mwebesa B. Bwana, Kyle D. Cobarrubias, Peter W. Hunt, Jeff N. Martin, Mary Carrington, David R. Bangsberg, P. Richard Harrigan, Mark A. Brockman, and Zabrina L. Brumme. Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity. J. Virol., 93(1), 1 Jan 2019. PubMed ID: 30305354. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(850-858) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Epitope Name | IY9 | |
Species (MHC/HLA) | human(B*39) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(135-143) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | IY9 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | vaccine antigen design |
Ojwach2021 Doty B. A. Ojwach, Paradise Madlala, Michelle Gordon, Thumbi Ndung'u, and Jaclyn K. Mann. Vulnerable targets in HIV-1 Pol for attenuation-based vaccine design. Virology, 554:1-8 doi, Feb 2021. PubMed ID: 33316731 Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(850-858) Integrase(135-143) DNA(4632..4658) |
Pol Epitope Map |
---|---|---|
Author Location | Integrase(135-143) | |
Epitope |
IQQEFGIPY
|
Epitope Alignment
|
Epitope Name | IY9 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | acute/early infection, HLA associated polymorphism, chronic infection, protective allele |
Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.