HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 44 matching records:

Displaying record number 57519

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location  
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 59821

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1785

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 58541

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name B7-IL9
Subtype B
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country United States
Experimental methods  
Keywords review, rate of progression, acute/early infection

Notes

References

Streeck2010 Hendrik Streeck and Douglas F. Nixon. T Cell Immunity in Acute HIV-1 Infection. J. Infect. Dis., 202(Suppl 2):S302-8, 15 Oct 2010. PubMed ID: 20846037. Show all entries for this paper.


Displaying record number 54796

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(332-340)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 59818

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57538

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp160(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Epitope Name I9GL
Species (MHC/HLA) human, transgenic mouse(B*07)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type polyepitope
Vaccine strain multiple epitope immunogen
Vaccine component HIV-1

Notes

References

Cardinaud2009 Sylvain Cardinaud, Romain Bouziat, Pierre-Simon Rohrlich, Sophie Tourdot, Laurence Weiss, Pierre Langlade-Demoyen, Anne Burgevin, Susana Fiorentino, Peter van Endert, and François A. Lemonnier. Design of a HIV-1-Derived HLA-B07.02-Restricted Polyepitope Construct. AIDS, 23(15):1945-1954, 24 Sep 2009. PubMed ID: 19644347. Show all entries for this paper.


Displaying record number 59174

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(848-856)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name env 848-856
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 60957

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp160(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Patient MHC/HLA 44149: A*0101, A*2401, B*0701, B*0801, Cw*0701, Cw*0702; 63794: A*0201, A*0201, B*0701, B*4401, Cw*0702, Cw*0704
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 893

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(848-856 LAI)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57378

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location  
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Epitope Name IL9 wt
Species (MHC/HLA) human(B*0702)
Immunogen in vitro stimulation or selection, peptide-HLA interaction
Country United States
Experimental methods Other
Keywords binding affinity, escape

Notes

References

Yang2010 Yue Yang, Jinghe Huang, Ildiko Toth, Mathias Lichterfeld, and Xu G. Yu. Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors. PLoS One, 5(12):e15084, 2010. PubMed ID: 21170342. Show all entries for this paper.


Displaying record number 59053

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Epitope Name IL9-Env
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country Japan, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, subtype comparisons

Notes

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 59823

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(B*41)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59820

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 53384

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location ( B consensus)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A31, A68, B7, B70, Cw1, Cw7
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 53404

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods Intracellular cytokine staining, T-cell Elispot, Tetramer binding
Keywords rate of progression, acute/early infection, characterizing CD8+ T cells

Notes

References

Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.


Displaying record number 53417

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(333-334)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Epitope Name IPR
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A68.1, B*07, B*3503, Cw*0401, Cw*0702, DQ2, DQ6, DR15, DR17, DR51, DR52
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape

Notes

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 53781

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp120
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) (B7)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, acute/early infection, early-expressed proteins, kinetics, viral fitness and reversion

Notes

References

Lichterfeld2005 Mathias Lichterfeld, Xu G. Yu, Sylvie Le Gall, and Marcus Altfeld. Immunodominance of HIV-1-Specific CD8+ T-Cell Responses in Acute HIV-1 Infection: At the Crossroads of Viral and Host Genetics. Trends Immunol., 26(3):166-171, Mar 2005. PubMed ID: 15745859. Show all entries for this paper.


Displaying record number 54292

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name B7-IL9(gp41)
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55032

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location  
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55485

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords superinfection

Notes

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.


Displaying record number 56080

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name Env1137
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.


Displaying record number 57174

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location  
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords immunodominance, acute/early infection

Notes

References

Liu2009c Yi Liu, John McNevin, Morgane Rolland, Hong Zhao, Wenjie Deng, Janine Maenza, Claire E. Stevens, Ann C. Collier, M. Juliana McElrath, and James I. Mullins. Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses. J. Infect. Dis., 200(12):1825-1833, 15 Dec 2009. PubMed ID: 19909083. Show all entries for this paper.


Displaying record number 1857

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41( SF2)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.


Displaying record number 894

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location  
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance, escape

Notes

References

Soudeyns1999 H. Soudeyns, S. Paolucci, C. Chappey, M. B. Daucher, C. Graziosi, M. Vaccarezza, O. J. Cohen, A. S. Fauci, and G. Pantaleo. Selective Pressure Exerted by Immunodominant Hiv-1-Specific Cytotoxic T Lymphocyte Responses during Primary Infection Drives Genetic Variation Restricted to the Cognate Epitope. Eur. J. Immunol., 29:3629-3635, 1999. PubMed ID: 10556818. Show all entries for this paper.


Displaying record number 895

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(848-856 LAI)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 896

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(848-856 subtype B)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, acute/early infection

Notes

References

Wilson1998b S. E. Wilson, S. L. Pedersen, J. C. Kunich, V. L. Wilkins, D. L. Mann, G. P. Mazzara, J. Tartaglia, C. L. Celum, and H. W. Sheppard. Cross-Clade Envelope Glycoprotein 160-Specific CD8+ Cytotoxic T Lymphocyte Responses in Early HIV Type 1 Clade B Infection. AIDS Res. Hum. Retroviruses, 14:925-937, 1998. PubMed ID: 9686639. Show all entries for this paper.


Displaying record number 897

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(843-851 HXB2)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, immunodominance

Notes

References

Hay1999a C. Hay, D. Ruhl, N. Basgoz, C. Wilson, J. Billingsley, M. DePasquale, R. D'Aquila, S. M. Wolinsky, J. M Crawfod, D. Montefiori, and B. D. Walker. Lack of Viral Escape and Defective In Vivo Activation of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes in Rapidly Progressive Infection. J. Virol., 73:5509-5519, 1999. PubMed ID: 10364299. Show all entries for this paper.


Displaying record number 1492

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Islam2001 S. A. Islam, C. M. Hay, K. E. Hartman, S. He, A. K. Shea, A. K. Trocha, M. J. Dynan, N. Reshamwala, S. P. Buchbinder, N. O. Basgoz, and S. A. Kalams. Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression. J. Virol., 75(10):4907-11, May 2001. URL: http://jvi.asm.org/cgi/content/full/75/10/4907. PubMed ID: 11312363. Show all entries for this paper.


Displaying record number 1545

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(843-851 SF2)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1668

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(848-856)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), immunodominance

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 892

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(848-856 LAI)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen  
Experimental methods  
Keywords mother-to-infant transmission

Notes

References

Brander1995a Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. pages IV--1--IV--9. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1995. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.


Displaying record number 52169

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(842-852)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name B7-IL9
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A3, B7, Cw7
Experimental methods  
Keywords dynamics, supervised treatment interruptions (STI), immunodominance, acute/early infection

Notes

References

Yu2002b Xu G. Yu, Marylyn M. Addo, Eric S. Rosenberg, William R. Rodriguez, Paul K. Lee, Cecily A. Fitzpatrick, Mary N. Johnston, Daryld. Strick, Philip J. R. Goulder, Bruce D. Walker, and Marcus Altfeld. Consistent Patterns in the Development and Immunodominance of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T-Cell Responses Following Acute HIV-1 Infection. J. Virol., 76(17):8690-8701, Sep 2002. PubMed ID: 12163589. Show all entries for this paper.


Displaying record number 52273

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name B7-IL9(gp41)
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A24, B27, B7
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.


Displaying record number 52586

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name EW10
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords class I down-regulation by Nef

Notes

References

Bobbitt2003 Kevin R. Bobbitt, Marylyn M. Addo, Marcus Altfeld, Tracey Filzen, Adewunmi A. Onafuwa, Bruce D. Walker, and Kathleen L. Collins. Rev Activity Determines Sensitivity of HIV-1-Infected Primary T Cells to CTL killing. Immunity, 18(2):289-299, Feb 2003. PubMed ID: 12594955. Show all entries for this paper.


Displaying record number 52625

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B14, B7, Cw*0702, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords binding affinity, acute/early infection, early-expressed proteins

Notes

References

Cao2003 Jianhong Cao, John McNevin, Sarah Holte, Lisa Fink, Lawrence Corey, and M. Juliana McElrath. Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection. J. Virol., 77(12):6867-6878, Jun 2003. PubMed ID: 12768006. Show all entries for this paper.


Displaying record number 53038

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 59819

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59822

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(C*05)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58267

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.


Displaying record number 54923

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location  
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA A*2501, A*3002; B*0702, B*1801
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type canarypox prime with gp120 boost
Vaccine strain B clade LAI, B clade MN
Vaccine component Gag-Pol, gp120, gp41

Notes

References

Horton2006a Helen Horton, Colin Havenar-Daughton, Deborah Lee, Erin Moore, Jianhong Cao, John McNevin, Thomas Andrus, Haiying Zhu, Abbe Rubin, Tuofu Zhu, Connie Celum, and M. Juliana McElrath. Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection. J. Virol., 80(19):9779-9788, Oct 2006. PubMed ID: 16973582. Show all entries for this paper.


Displaying record number 53805

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp160( clade A, B, C, D)
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Subtype A, B, C, D
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*6802, A*6802, B*1303, B*1401, Cw*0602, Cw*1701
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, variant cross-reactivity

Notes

References

McKinnon2005 Lyle R. McKinnon, T. Blake Ball, Joshua Kimani, Charles Wachihi, Lucy Matu, Ma Luo, Joanne Embree, Keith R. Fowke, and Francis A. Plummer. Cross-Clade CD8+ T-Cell Responses With a Preference for the Predominant Circulating Clade. J. Acquir. Immune Defic. Syndr., 40(3):245-249, 1 Nov 2005. PubMed ID: 16249696. Show all entries for this paper.


Displaying record number 55476

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Show epitope variants
Subtype A1, B, C, CRF01_AE
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 56136

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGL Epitope Alignment
IPRRIRQGL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*6802, A*7401, B*1510, B*4901, Cw*0304, Cw*0701; B*0702, B*1503, Cw*0202, Cw*0702; A*2902, A*3601, B*1510, B*4201, Cw*0304, Cw*1701
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Proliferation
Keywords assay or method development

Notes

References

McKinnon2008 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Nyakio Chinga, Anne Maingi, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-gamma and Proliferation Responses. J. Acquir. Immune Defic. Syndr., 49(2):123-127, 1 Oct 2008. PubMed ID: 18769359. Show all entries for this paper.


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