HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 54519

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HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41(843-851)
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Epitope Name IF9
Subtype A
Species (MHC/HLA) human(B*07)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Proliferation
Keywords assay or method development

Notes

References

McKinnon2007 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Paul J. McLaren, Jillian L. M. Waruk, Xiaojuan Mao, Sue Ramdahin, A. Omu Anzala, Jane Kamene, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Epitope Cross-Reactivity Frequently Differs between Central and Effector Memory HIV-Specific CD8+ T Cells. J. Immunol., 178(6):3750-3756, 15 Mar 2007. PubMed ID: 17339473. Show all entries for this paper.


Displaying record number 62226

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HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Show epitope variants
Epitope Name Env-IF9
Subtype C
Species (MHC/HLA) human(B*42)
Immunogen HIV-1 infection
Patient MHC/HLA 517-C: A*30:02, A*68:02, B*15:10, B*42:01, C*03:04, C*17:01; 517-M: A*30:02, A*30:04, B*42:01, B*58:02, C*06:02, C*17:01
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords dynamics, responses in children, mother-to-infant transmission, rate of progression, mutation acquisition

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 57889

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HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Patient MHC/HLA CAP239: A*01:01, A*29:02, B*42:01, B*58:01, C*06:02, C*07:02
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.


Displaying record number 58704

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HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Epitope Name Env-IF9
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*30:01, B*42:01, C*17:01
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 59440

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HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env(843-851)
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Show epitope variants
Epitope Name Env-IF9
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords immunodominance, escape, optimal epitope, novel epitope

Notes

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 1361

Download this epitope record as JSON.

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location gp41
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Subtype A
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao2000 H. Cao, I. Mani, R. Vincent, R. Mugerwa, P. Mugyenyi, P. Kanki, J. Ellner, and B. D. Walker. Cellular immunity to human immunodeficiency virus type 1 (HIV-1) clades: relevance to HIV-1 vaccine trials in Uganda. J. Infect. Dis., 182(5):1350-6, Nov 2000. PubMed ID: 11023458. Show all entries for this paper.


Displaying record number 58266

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HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.


Displaying record number 55478

Download this epitope record as JSON.

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Subtype A1, B, CRF01_AE, CRF06_cpx
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, variant cross-reactivity, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 56137

Download this epitope record as JSON.

HXB2 Location gp160(843-851)
gp41(332-340)
DNA(8751..8777)
gp160 Epitope Map
Author Location Env
Epitope IPRRIRQGF Epitope Alignment
IPRRIRQGF epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*68:02, A*74:01, B*15:10, B*49:01, C*03:04, C*07:01; A*03:01, A*30:01, B*18:03, B*42:01, C*04:01, C*17:01; B*07:02, B*15:03, C*02:02, C*07:02; A*01:01, A*23:01, B*07:02, B*45:01, C*07:02, C*16:01; A*29:02, A*36:01, B*15:10, B*42:01, C*03:04, C*17:01
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Proliferation
Keywords assay or method development

Notes

References

McKinnon2008 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Nyakio Chinga, Anne Maingi, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-gamma and Proliferation Responses. J. Acquir. Immune Defic. Syndr., 49(2):123-127, 1 Oct 2008. PubMed ID: 18769359. Show all entries for this paper.


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