Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 56139

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HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	Env
Epitope	IPRRIRQGA	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*68:02, A*74:01, B*15:10, B*49:01, C*03:04, C*07:01; A*03:01, A*30:01, B*18:03, B*42:01, C*04:01, C*17:01; B*07:02, B*15:03, C*02:02, C*07:02; A*29:02, A*36:01, B*15:10, B*42:01, C*03:04, C*17:01
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ, Proliferation
Keywords	assay or method development

Notes

• To evaluate the use of IFN-gamma ELISpot and proliferation assays, the two were compared in a cohort of HIV-1-infected Kenyan sex-workers. ELISpot does not always correlate with viral load and replication or disease progression. The exclusive use of these assays makes definition of CTL response in disease incomplete, especially for memory T cells.
• Despite assaying for 24 INF-gamma and 41 proliferative responses, only 5 of these responses overlapped in the same subject. 18 peptide-epitopes including 10 epitopes and their variants were used in this study.
• IPRRIRQGA elicited proliferation in 1 subject; ELISpot responses in 2 subjects; both responses in 1 subject.

References

McKinnon2008 Lyle R. McKinnon, T. Blake Ball, Charles Wachihi, Nyakio Chinga, Anne Maingi, Ma Luo, Keith R. Fowke, and Francis A. Plummer. Substantial Intrapatient Differences in the Breadth and Specificity of HIV-Specific CD8+ T-Cell Interferon-gamma and Proliferation Responses. J. Acquir. Immune Defic. Syndr., 49(2):123-127, 1 Oct 2008. PubMed ID: 18769359. Show all entries for this paper.

Displaying record number 58269

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HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	Env
Epitope	IPRRIRQGA	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

• To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
• Env epitope IPRRIRQGA stimulated peak EliSpot response in no subjects, but stimulated peak proliferation response in 3 subjects. None of those subjects had reached disease end point.

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.