HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 19 matching records:

Displaying record number 52350

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol(489-456)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B*0702, B*3501, B*5101, B*5301)
Immunogen HIV-1 infection
Patient MHC/HLA A24, A26, B35, B51, Cw3
Experimental methods  
Keywords supertype, HLA cross-presentation, TCR usage

Notes

References

Ueno2002 Takamasa Ueno, Hiroko Tomiyama, and Masafumi Takiguchi. Single T Cell Receptor-Mediated Recognition of an Identical HIV-Derived Peptide Presented by Multiple HLA Class I Molecules. J. Immunol., 169(9):4961-4969, 1 Nov 2002. PubMed ID: 12391209. Show all entries for this paper.


Displaying record number 53446

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol( HXB2, LAI)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Subtype B
Species (MHC/HLA) human(B*1501, B*3501)
Immunogen HIV-1 infection
Patient MHC/HLA A*2402, A*2601, B*3501, B*5101
Country Japan
Experimental methods Chromium-release assay, Cytokine production, Tetramer binding
Keywords binding affinity, HLA cross-presentation, immunotherapy, TCR usage, characterizing CD8+ T cells

Notes

References

Ueno2004b Takamasa Ueno, Mamoru Fujiwara, Hiroko Tomiyama, Masafumi Onodera, and Masafumi Takiguchi. Reconstitution of Anti-HIV Effector Functions of Primary Human CD8 T Lymphocytes by Transfer of HIV-Specific alpha-beta TCR Genes. Eur. J. Immunol., 34(12):3379-3388, Dec 2004. PubMed ID: 15517606. Show all entries for this paper.


Displaying record number 57320

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Subtype A, CRF02_AG, CRF06_cpx, CRF09_cpx
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Burkina Faso
Experimental methods Other
Keywords drug resistance

Notes

References

Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.


Displaying record number 57585

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT(293-301)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Epitope Name IL9
Subtype B
Species (MHC/HLA) (B*35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 495

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location ( SF2)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression

Notes

References

Kawana1999 A. Kawana, H. Tomiyama, M. Takiguchi, T. Shioda, T. Nakamura, and A. Iwamoto. Accumulation of Specific Amino Acid Substitutions in HLA-B35-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 15:1099-1107, 1999. PubMed ID: 10461830. Show all entries for this paper.


Displaying record number 57947

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT(293-301)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Epitope Name IL9
Subtype A1, B, C
Species (MHC/HLA) human(B35)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus
Vaccine strain B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component Env, Gag-Pol

Notes

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.


Displaying record number 57336

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol(448-)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Epitope Name Pol448
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country Japan
Experimental methods Chromium-release assay, Cytotoxicity assay, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords binding affinity

Notes

References

Ueno2007 Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka, and Masafumi Takiguchi. Altering Effects of Antigenic Variations in HIV-1 on Antiviral Effectiveness of HIV-Specific CTLs. J. Immunol., 178(9):5513-5523, 1 May 2007. PubMed ID: 17442933. Show all entries for this paper.


Displaying record number 57925

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol(448-456)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*2402, B*3501, B*3503, Cw*0303, Cw*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Herbeck2011 Joshua T. Herbeck, Morgane Rolland, Yi Liu, Sherry McLaughlin, John McNevin, Hong Zhao, Kim Wong, Julia N. Stoddard, Dana Raugi, Stephanie Sorensen, Indira Genowati, Brian Birditt, Angela McKay, Kurt Diem, Brandon S. Maust, Wenjie Deng, Ann C. Collier, Joanne D. Stekler, M. Juliana McElrath, and James I. Mullins. Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes. J. Virol., 85(15):7523-7534, Aug 2011. PubMed ID: 21593162. Show all entries for this paper.


Displaying record number 494

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT(448-456 SF2)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B35, B51)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 53445

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol( HXB2, LAI)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Patient MHC/HLA A*2402, A*2601, B*3501, B*5101
Country Japan
Experimental methods Chromium-release assay, Cytokine production, Tetramer binding
Keywords binding affinity, kinetics, TCR usage, characterizing CD8+ T cells

Notes

References

Ueno2004 Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi Oka, and Masafumi Takiguchi. Functionally Impaired HIV-Specific CD8 T Cells Show High Affinity TCR-Ligand Interactions. J. Immunol., 173(9):5451-547, 1 Nov 2004. PubMed ID: 15494492. Show all entries for this paper.


Displaying record number 496

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT(448-456 SF2)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 61556

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol(448-456)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords TCR usage

Notes

References

Ueno2003 Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi Oka, and Masafumi Takiguchi. HLA Class I-Restricted Recognition of an HIV-Derived Epitope Peptide by a Human T Cell Receptor Alpha Chain Having a V-delta-1 Variable Segment. Eur. J. Immunol., 33(10):2910-2916, Oct 2003. PubMed ID: 14515275. Show all entries for this paper.


Displaying record number 58621

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol(448-456 SF2-24)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Epitope Name HIV-B35-SF2-24
Species (MHC/HLA) human(B*3501, B*5101)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 1344

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol(448-456 SF2-24)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Epitope Name HIV-B35-SF2-24
Species (MHC/HLA) human(B*3501, B*5101)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama2000b H. Tomiyama, N. Yamada, H. Komatsu, K. Hirayama, and M. Takiguchi. A single CTL clone can recognize a naturally processed HIV-1 epitope presented by two different HLA class I molecules. Eur. J. Immunol., 30(9):2521-30, Sep 2000. PubMed ID: 11009085. Show all entries for this paper.


Displaying record number 52980

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT(293-301)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B51)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51, Cw03, Cw6, DQ7, DR4, DR8
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape

Notes

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 1686

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol(447-455)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human(B51)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 53413

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT Pol(286-294)
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Show epitope variants
Epitope Name IPL
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A68.1, B*07, B*3503, Cw*0401, Cw*0702, DQ2, DQ6, DR15, DR17, DR51, DR52
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords rate of progression, immunodominance, escape

Notes

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


Displaying record number 58103

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location Pol
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*2403, A*6801, B*3503, B*3801, Cw*0401, Cw*1203; A*0101, A*2402, B*3503, B*5701, Cw*0401, Cw*0602
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 56208

HXB2 Location Pol(448-456)
RT(293-301)
DNA(3426..3452)
Pol Epitope Map
Author Location RT
Epitope IPLTEEAEL Epitope Alignment
IPLTEEAEL epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Garrison2007 Keith E. Garrison, R. Brad Jones, Duncan A. Meiklejohn, Naveed Anwar, Lishomwa C. Ndhlovu, Joan M. Chapman, Ann L. Erickson, Ashish Agrawal, Gerald Spotts, Frederick M. Hecht, Seth Rakoff-Nahoum, Jack Lenz, Mario A. Ostrowski, and Douglas F. Nixon. T Cell Responses to Human Endogenous Retroviruses in HIV-1 Infection. PLoS Pathog., 3(11):e165, Nov 2007. PubMed ID: 17997601. Show all entries for this paper.


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