HIV molecular immunology database
Found 20 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(489-456) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*07:02, B*35:01, B*51:01, B*53:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A24, A26, B35, B51, Cw3 | |
Experimental methods | ||
Keywords | supertype, HLA cross-presentation, TCR usage |
Ueno2002 Takamasa Ueno, Hiroko Tomiyama, and Masafumi Takiguchi. Single T Cell Receptor-Mediated Recognition of an Identical HIV-Derived Peptide Presented by Multiple HLA Class I Molecules. J. Immunol., 169(9):4961-4969, 1 Nov 2002. PubMed ID: 12391209. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol( HXB2, LAI) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*15:01, B*35:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*24:02, A*26:01, B*35:01, B*51:01 | |
Country | Japan | |
Experimental methods | Chromium-release assay, Cytokine production, Tetramer binding | |
Keywords | binding affinity, HLA cross-presentation, immunotherapy, TCR usage, characterizing CD8+ T cells |
Ueno2004b Takamasa Ueno, Mamoru Fujiwara, Hiroko Tomiyama, Masafumi Onodera, and Masafumi Takiguchi. Reconstitution of Anti-HIV Effector Functions of Primary Human CD8 T Lymphocytes by Transfer of HIV-Specific alpha-beta TCR Genes. Eur. J. Immunol., 34(12):3379-3388, Dec 2004. PubMed ID: 15517606. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | RT(293-301) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Epitope Name | IL9 | |
Subtype | B | |
Species (MHC/HLA) | (B*35) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Subtype | A, CRF02_AG, CRF06_cpx, CRF09_cpx | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | Burkina Faso | |
Experimental methods | Other | |
Keywords | drug resistance |
Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(448-456) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*02:01, A*24:02, B*35:01, B*35:03, C*03:03, C*04:01 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | acute/early infection |
Herbeck2011 Joshua T. Herbeck, Morgane Rolland, Yi Liu, Sherry McLaughlin, John McNevin, Hong Zhao, Kim Wong, Julia N. Stoddard, Dana Raugi, Stephanie Sorensen, Indira Genowati, Brian Birditt, Angela McKay, Kurt Diem, Brandon S. Maust, Wenjie Deng, Ann C. Collier, Joanne D. Stekler, M. Juliana McElrath, and James I. Mullins. Demographic Processes Affect HIV-1 Evolution in Primary Infection before the Onset of Selective Processes. J. Virol., 85(15):7523-7534, Aug 2011. PubMed ID: 21593162. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | ( SF2) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | rate of progression |
Kawana1999 A. Kawana, H. Tomiyama, M. Takiguchi, T. Shioda, T. Nakamura, and A. Iwamoto. Accumulation of Specific Amino Acid Substitutions in HLA-B35-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 15:1099-1107, 1999. PubMed ID: 10461830. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | RT(293-301) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Epitope Name | IL9 | |
Subtype | A1, B, C | |
Species (MHC/HLA) | human(B35) | |
Immunogen | vaccine | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | vaccine-induced immune responses |
Vaccine type | adenovirus |
---|---|
Vaccine strain | B clade HXB2, A clade 92RW020, C clade 97ZA012 |
Vaccine component | Env, Gag-Pol |
Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(448-) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Epitope Name | Pol448 | |
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | Chromium-release assay, Cytotoxicity assay, Intracellular cytokine staining, Proliferation, Tetramer binding | |
Keywords | binding affinity |
Ueno2007 Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka, and Masafumi Takiguchi. Altering Effects of Antigenic Variations in HIV-1 on Antiviral Effectiveness of HIV-Specific CTLs. J. Immunol., 178(9):5513-5523, 1 May 2007. PubMed ID: 17442933. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | RT(448-456 SF2) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35, B51) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.
Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | RT(448-456 SF2) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.
Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(448-456) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining | |
Keywords | TCR usage |
Ueno2003 Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi Oka, and Masafumi Takiguchi. HLA Class I-Restricted Recognition of an HIV-Derived Epitope Peptide by a Human T Cell Receptor Alpha Chain Having a V-delta-1 Variable Segment. Eur. J. Immunol., 33(10):2910-2916, Oct 2003. PubMed ID: 14515275. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol( HXB2, LAI) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A*24:02, A*26:01, B*35:01, B*51:01 | |
Country | Japan | |
Experimental methods | Chromium-release assay, Cytokine production, Tetramer binding | |
Keywords | binding affinity, kinetics, TCR usage, characterizing CD8+ T cells |
Ueno2004 Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi Oka, and Masafumi Takiguchi. Functionally Impaired HIV-Specific CD8 T Cells Show High Affinity TCR-Ligand Interactions. J. Immunol., 173(9):5451-547, 1 Nov 2004. PubMed ID: 15494492. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(448-456 SF2-24) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Epitope Name | HIV-B35-SF2-24 | |
Species (MHC/HLA) | human(B*35:01, B*51:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
Tomiyama2000b H. Tomiyama, N. Yamada, H. Komatsu, K. Hirayama, and M. Takiguchi. A single CTL clone can recognize a naturally processed HIV-1 epitope presented by two different HLA class I molecules. Eur. J. Immunol., 30(9):2521-30, Sep 2000. PubMed ID: 11009085. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(448-456 SF2-24) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Epitope Name | HIV-B35-SF2-24 | |
Species (MHC/HLA) | human(B*35:01, B*51:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | RT(293-301) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B51) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8 | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, escape |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(447-455) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B51) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | RT Pol(286-294) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | IPL | |
Species (MHC/HLA) | human(B7) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A68.1, B*07, B*35:03, C*04:01, C*07:02, DQ2, DQ6, DR15, DR17, DR51, DR52 | |
Experimental methods | CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Tetramer binding | |
Keywords | rate of progression, immunodominance, escape |
Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | RT(293-301) | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Epitope Name | IL-9 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | acute/early infection, HLA associated polymorphism, chronic infection, protective allele |
Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Species (MHC/HLA) | human | |
Immunogen | in vitro stimulation or selection, HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords |
Garrison2007 Keith E. Garrison, R. Brad Jones, Duncan A. Meiklejohn, Naveed Anwar, Lishomwa C. Ndhlovu, Joan M. Chapman, Ann L. Erickson, Ashish Agrawal, Gerald Spotts, Frederick M. Hecht, Seth Rakoff-Nahoum, Jack Lenz, Mario A. Ostrowski, and Douglas F. Nixon. T Cell Responses to Human Endogenous Retroviruses in HIV-1 Infection. PLoS Pathog., 3(11):e165, Nov 2007. PubMed ID: 17997601. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(448-456) RT(293-301) DNA(3426..3452) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
IPLTEEAEL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Patient MHC/HLA | A*24:03, A*68:01, B*35:03, B*38:01, C*04:01, C*12:03; A*01:01, A*24:02, B*35:03, B*57:01, C*04:01, C*06:02 | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | vaccine-induced immune responses |
Vaccine type | adenovirus type 5 (Ad5), DNA prime with Ad5 boost |
---|---|
Vaccine strain | B clade IIIB, B clade JRFL, B clade CAM-1 |
Vaccine component | Gag, Nef, Pol |
Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.