Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 1631

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HXB2 Location	Pol(804-813) Integrase(89-98) DNA(4494..4523)	Pol Epitope Map
Author Location	Pol
Epitope	IPAETGQETA	Epitope Alignment
Species (MHC/HLA)	human(B56)
Immunogen
Experimental methods
Keywords

Notes

• The program Epimatrix was used in conjunction with the program Conservatrix to identify conserved regions of HIV that might serve as epitopes.
• A subset of the potential epitopes was identified that could bind to the appropriate HLA-allele, and 15 predicted B7 superfamily (HLA B7, B8, and B58) epitopes could stimulate IFNγ production in an ELISPOT assay.
• IPAETGQETA was newly identified as an HLA-B56 epitope in this study.

References

DeGroot2001 A. S. De Groot, A. Bosma, N. Chinai, J. Frost, B. M. Jesdale, M. A. Gonzalez, W. Martin, and C. Saint-Aubin. From genome to vaccine: in silico predictions, ex vivo verification. Vaccine, 19(31):4385-95, 14 Aug 2001. PubMed ID: 11483263. Show all entries for this paper.

Displaying record number 52880

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HXB2 Location	Pol(804-813) Integrase(89-98) DNA(4494..4523)	Pol Epitope Map
Author Location	Pol
Epitope	IPAETGQETA	Epitope Alignment
Epitope Name	1294
Subtype	multiple
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, A3, B58, B7, Cw7
Country	United States
Experimental methods	T-cell Elispot
Keywords	binding affinity, computational epitope prediction, novel epitope

Notes

• Epitopes defined using sequence parsing and matching algorithm Conservatrix, and epitope prediction tool EpiMatrix, were shown to be conserved in a broad range of HIV-1 sequences derived from different parts of the world. 31 novel highly conserved HIV-1 epitopes were found, among which four were recognized as promiscuous epitopes and five as MHC supertypes.
• Estimated binding probability for IPAETGQETA: 8%

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.

Displaying record number 52226

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HXB2 Location	Pol(804-813) Integrase(89-98) DNA(4494..4523)	Pol Epitope Map
Author Location	Pol(805-814 BH10, LAI)
Epitope	IPAETGQETA	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	computer prediction
Experimental methods	Other
Keywords	computational epitope prediction, T-cell crossreactivity to human proteins

Notes

• This study employs an antigenic similarity matrix to compare HIV-1 antigenic determinants with human proteins.
• This CTL epitope (the HIV-1 LAI fragment with high similarity to a human protein overlapping this epitope is PAETGQETAY) has similarity with Integrin beta-4 precursor (GP150)(CD104), fragment PAETNGEITAY.

References

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.