HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 61521

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HXB2 Location Pol(464-474)
RT(309-319)
DNA(3474..3506)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGVYY Epitope Alignment
ILKEPVHGVYY epitope logo
Show epitope variants
Epitope Name IY11
Subtype B
Species (MHC/HLA) human(B*52:01)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Relative replication capacity assay
Keywords escape, mutation acquisition, novel epitope, chronic infection

Notes

References

Murakoshi2017 Hayato Murakoshi, Madoka Koyanagi, Takayuki Chikata, Mohammad Arif Rahman, Nozomi Kuse, Keiko Sakai, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Accumulation of Pol Mutations Selected by HLA-B*52:01-C*12:02 Protective Haplotype-Restricted Cytotoxic T Lymphocytes Causes Low Plasma Viral Load Due to Low Viral Fitness of Mutant Viruses. J. Virol., 91(4), 15 Feb 2017. PubMed ID: 27903797. Show all entries for this paper.


Displaying record number 61492

Download this epitope record as JSON.

HXB2 Location Pol(464-474)
RT(309-319)
DNA(3474..3506)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGVYY Epitope Alignment
ILKEPVHGVYY epitope logo
Epitope Name IY11
Subtype B
Species (MHC/HLA) human(C*12:02)
Immunogen HIV-1 infection
Country Japan
Experimental methods Chromium-release assay, Intracellular cytokine staining, Other
Keywords optimal epitope, NK cells, novel epitope, chronic infection

Notes

References

Chikata2017 Takayuki Chikata, Hayato Murakoshi, Madoka Koyanagi, Kazutaka Honda, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Control of HIV-1 by an HLA-B*52:01-C*12:02 Protective Haplotype. J. Infect. Dis., 216(11):1415-1424, 12 Dec 2017. PubMed ID: 28968792. Show all entries for this paper.


Displaying record number 62523

Download this epitope record as JSON.

HXB2 Location Pol(464-474)
RT(309-319)
DNA(3474..3506)
Pol Epitope Map
Author Location Pol(464-474)
Epitope ILKEPVHGVYY Epitope Alignment
ILKEPVHGVYY epitope logo
Epitope Name Pol-IY11
Subtype B
Species (MHC/HLA) human(C*12:02)
Immunogen HIV-1 infection, virus
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Other, T2 stabilization assay
Keywords immunodominance, chronic infection, protective allele

Notes

References

Chikata2019 Takayuki Chikata, Wayne Paes, Tomohiro Akahoshi, Thomas Partridge, Hayato Murakoshi, Hiroyuki Gatanaga, Nicola Ternette, Shinichi Oka, Persephone Borrow, and Masafumi Takiguchi. Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C*12:02, a Protective Allele, Using an Immunopeptidomics Approach. J. Virol., 93(17), 1 Sep 2019. PubMed ID: 31217245. Show all entries for this paper.


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