HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 61942

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location HIV-1
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Other
Keywords assay or method development

Notes

References

Stoll2015 Andrej Stoll, Silke Bergmann, Christiane Mummert, Sandra M. Mueller-Schmucker, Bernd M. Spriewald, Ellen G. Harrer, and Thomas Harrer. Identification of HLA-C Restricted, HIV-1-Specific CTL Epitopes by Peptide Induced Upregulation of HLA-C Expression. J. Immunol. Methods, 418:9-18, Mar 2015. PubMed ID: 25633660. Show all entries for this paper.


Displaying record number 52868

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Epitope Name 1249
Subtype multiple
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A30, B39; A2, A3, B44, Cw5, Cw7; A2, A30, B35, B49, Cw4, Cw7
Country United States
Experimental methods T-cell Elispot
Keywords binding affinity, computational epitope prediction, HLA cross-presentation

Notes

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.


Displaying record number 52976

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Species (MHC/HLA) human(B15)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A32, B15, B51, Cw03, Cw6, DQ7, DR4, DR8
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape

Notes

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.


Displaying record number 56002

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Epitope Name IY10(RT)
Subtype B
Species (MHC/HLA) human(B15)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 56389

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location RT(309-318)
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Epitope Name IY10
Subtype B
Species (MHC/HLA) human(B*15)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 541

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location RT(476-485 LAI)
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Subtype B
Species (MHC/HLA) human(B*1501)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61168

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location Pol(464-473)
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Show epitope variants
Epitope Name IY10
Subtype B
Species (MHC/HLA) human(B*1510)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection, variant cross-reactivity

Notes

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 52440

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Subtype A, B, D
Species (MHC/HLA) human(B62)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 540

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location RT(476-485 LAI)
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Subtype B
Species (MHC/HLA) human(B62)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 58695

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(Cw*0303)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism

Notes

References

Blais2012 Marie-Eve Blais, Yonghong Zhang, Tim Rostron, Harry Griffin, Stephen Taylor, Keyi Xu, Huiping Yan, Hao Wu, Ian James, Mina John, Tao Dong, and Sarah L. Rowland-Jones. High Frequency of HIV Mutations Associated with HLA-C Suggests Enhanced HLA-C-Restricted CTL Selective Pressure Associated with an AIDS-Protective Polymorphism. J. Immunol., 188(9):4663-4670, 1 May 2012. PubMed ID: 22474021. Show all entries for this paper.


Displaying record number 58625

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location Pol(463-472)
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Epitope Name Pol 463-10 or IY10
Subtype B
Species (MHC/HLA) human(Cw*1202)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Relative replication capacity assay
Keywords escape, optimal epitope, novel epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61910

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Show epitope variants
Epitope Name Pol IY10
Species (MHC/HLA) human(Cw*1202)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication, HLA binding, Other
Keywords NK cells

Notes

References

Lin2016 Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, and Masafumi Takiguchi. HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C*12:02/C*14:03. Cell Rep., 17(9):2210-2220, 22 Nov 2016. PubMed ID: 27880898. Show all entries for this paper.


Displaying record number 57919

HXB2 Location Pol(464-473)
RT(309-318)
DNA(3474..3503)
Pol Epitope Map
Author Location Pol(463-472)
Epitope ILKEPVHGVY Epitope Alignment
ILKEPVHGVY epitope logo
Show epitope variants
Epitope Name Pol 463-10 or IY10
Subtype B
Species (MHC/HLA) human(Cw*1202)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Relative replication capacity assay
Keywords escape, optimal epitope, novel epitope

Notes

References

Honda2011 Kazutaka Honda, Nan Zheng, Hayato Murakoshi, Masao Hashimoto, Keiko Sakai, Mohamed Ali Borghan, Takayuki Chikata, Madoka Koyanagi, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Selection of Escape Mutant by HLA-C-Restricted HIV-1 Pol-Specific Cytotoxic T Lymphocytes Carrying Strong Ability to Suppress HIV-1 Replication. Eur. J. Immunol., 41(1):197-106, Jan 2011. PubMed ID: 21182081. Show all entries for this paper.


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