HIV molecular immunology database
Found 15 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | HIV-1 | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Epitope Name | IV9 | |
Subtype | B | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Country | Germany | |
Experimental methods | CD8 T-cell Elispot - IFNγ, HLA binding, Other | |
Keywords | assay or method development |
Stoll2015 Andrej Stoll, Silke Bergmann, Christiane Mummert, Sandra M. Mueller-Schmucker, Bernd M. Spriewald, Ellen G. Harrer, and Thomas Harrer. Identification of HLA-C Restricted, HIV-1-Specific CTL Epitopes by Peptide Induced Upregulation of HLA-C Expression. J. Immunol. Methods, 418:9-18, Mar 2015. PubMed ID: 25633660. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Epitope Name | 1249 | |
Subtype | multiple | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | T-cell Elispot | |
Keywords | binding affinity, computational epitope prediction, HLA cross-presentation |
DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Epitope Name | 1249 | |
Subtype | multiple | |
Species (MHC/HLA) | human(A2) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A2, A30, B39; A2, A3, B44, Cw5, Cw7; A2, A30, B35, B49, Cw4, Cw7 | |
Country | United States | |
Experimental methods | T-cell Elispot | |
Keywords | binding affinity, computational epitope prediction, HLA cross-presentation |
DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | RT(309-318) | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Epitope Name | IY10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*15) | |
Immunogen | HIV-1 infection | |
Country | Australia, Canada, Germany, United States | |
Experimental methods | ||
Keywords | HLA associated polymorphism |
Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | RT(309-317) | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B15) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A3, A32, B15, B51, C*03, Cw6, DQ7, DR4, DR8 | |
Country | Netherlands | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, escape |
Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Epitope Name | IY10(RT) | |
Subtype | B | |
Species (MHC/HLA) | human(B15) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | chronic infection |
Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | RT(476-485 LAI) | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*15:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(464-473) | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | IY10 | |
Subtype | B | |
Species (MHC/HLA) | human(B*15:10) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other | |
Keywords | acute/early infection, variant cross-reactivity |
Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | RT(476-485 LAI) | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B62) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | review |
McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.
Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Subtype | A, B, D | |
Species (MHC/HLA) | human(B62) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Show epitope variants | ||
Subtype | B | |
Species (MHC/HLA) | human(C*03:03) | |
Immunogen | HIV-1 infection | |
Country | China | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | escape, HLA associated polymorphism |
Blais2012 Marie-Eve Blais, Yonghong Zhang, Tim Rostron, Harry Griffin, Stephen Taylor, Keyi Xu, Huiping Yan, Hao Wu, Ian James, Mina John, Tao Dong, and Sarah L. Rowland-Jones. High Frequency of HIV Mutations Associated with HLA-C Suggests Enhanced HLA-C-Restricted CTL Selective Pressure Associated with an AIDS-Protective Polymorphism. J. Immunol., 188(9):4663-4670, 1 May 2012. PubMed ID: 22474021. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Pol IY10 | |
Species (MHC/HLA) | human(C*12:02) | |
Immunogen | HIV-1 infection | |
Experimental methods | CTL suppression of replication, HLA binding, Other | |
Keywords | NK cells |
Lin2016 Zhansong Lin, Kimiko Kuroki, Nozomi Kuse, Xiaoming Sun, Tomohiro Akahoshi, Ying Qi, Takayuki Chikata, Takuya Naruto, Madoka Koyanagi, Hayato Murakoshi, Hiroyuki Gatanaga, Shinichi Oka, Mary Carrington, Katsumi Maenaka, and Masafumi Takiguchi. HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C*12:02/C*14:03. Cell Rep., 17(9):2210-2220, 22 Nov 2016. PubMed ID: 27880898. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(463-472) | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Epitope Name | Pol 463-10 or IY10 | |
Subtype | B | |
Species (MHC/HLA) | human(C*12:02) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Relative replication capacity assay | |
Keywords | escape, optimal epitope, novel epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(463-472) | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Pol 463-10 or IY10 | |
Subtype | B | |
Species (MHC/HLA) | human(C*12:02) | |
Immunogen | HIV-1 infection | |
Country | Japan | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining, Relative replication capacity assay | |
Keywords | escape, optimal epitope, novel epitope |
Honda2011 Kazutaka Honda, Nan Zheng, Hayato Murakoshi, Masao Hashimoto, Keiko Sakai, Mohamed Ali Borghan, Takayuki Chikata, Madoka Koyanagi, Yoshiko Tamura, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Selection of Escape Mutant by HLA-C-Restricted HIV-1 Pol-Specific Cytotoxic T Lymphocytes Carrying Strong Ability to Suppress HIV-1 Replication. Eur. J. Immunol., 41(1):197-106, Jan 2011. PubMed ID: 21182081. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(464-473) RT(309-318) DNA(3474..3503) |
Pol Epitope Map |
---|---|---|
Author Location | RT(309-318) | |
Epitope |
ILKEPVHGVY
|
Epitope Alignment
|
Epitope Name | IY10 | |
Subtype | B, C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection, engineered | |
Experimental methods | Other, Relative replication capacity assay | |
Keywords | acute/early infection, HLA associated polymorphism, chronic infection, protective allele |
Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.