HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 149 matching records:

Displaying record number 1581

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, immunodominance

Notes

References

ScottAlgara2001 D. Scott-Algara, F. Buseyne, S. Blanche, C. Rouzioux, C. Jouanne, F. Romagne, and Y. Riviere. Frequency and phenotyping of human immunodeficiency virus (HIV)-specific CD8+ T cells in HIV-infected children, using major histocompatibility complex class I peptide tetramers. J. Infect. Dis., 183(11):1565-73, 1 Jun 2001. PubMed ID: 11343205. Show all entries for this paper.


Displaying record number 1404

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Rinaldo2000 C. R. Rinaldo, Jr., X. L. Huang, Z. Fan, J. B. Margolick, L. Borowski, A. Hoji, C. Kalinyak, D. K. McMahon, S. A. Riddler, W. H. Hildebrand, R. B. Day, and J. W. Mellors. Anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1-infected patients with advanced immunodeficiency. J. Virol., 74(9):4127-38, May 2000. URL: http://jvi.asm.org/cgi/content/full/74/9/4127. PubMed ID: 10756025. Show all entries for this paper.


Displaying record number 62244

HXB2 Location Pol(464-472)
RT(309-317)
DNA(1327..1353)
Pol Epitope Map
Author Location Pol(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Epitope Name Pol-IV9
Subtype C
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Patient MHC/HLA 021-C: A*0205, A*2902, B*4201, B*4403, Cw*0210, Cw*1701; 021-M: A*0205, A*3301, B*4201, B*4403, Cw*0210, Cw*1701
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 54575

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 53091

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT Pol(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 1768

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords rate of progression, acute/early infection

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 54794

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 499

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Huang2000 X. L. Huang, Z. Fan, C. Kalinyak, J. W. Mellors, and C. R. Rinaldo. CD8+ T Cell Gamma Interferon Production Specific for Human Immunodeficiency Virus Type 1 (HIV-1) in HIV-1-Infected Subjects. Clin. Diagn. Lab. Immunol., 7:279-287, 2000. PubMed ID: 10702505. Show all entries for this paper.


Displaying record number 59811

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT Pol(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56712

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317 HIV-1 NL4-3.1)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen virus
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Cruz2009 Justin De La Cruz, Ayub Ali, Hwee L Ng, and Otto O Yang. Disruption of an env Tyrosine-Dependent Sorting Signal Does Not Affect Susceptibility of HIV-1 to Cytotoxic T Lymphocytes. AIDS, 23(11):1449-1451, 17 Jul 2009. PubMed ID: 19564727. Show all entries for this paper.


Displaying record number 59118

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location HIV-1
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords binding affinity, elite controllers

Notes

References

Schellens2014 Ingrid M. M. Schellens, Hilde B. Spits, Marjon Navis, Geertje H. A. Westerlaken, Nening M. Nanlohy, Luc E. Coffeng, Neeltje Kootstra, Frank Miedema, Hanneke Schuitemaker, José A. M. Borghans, and Debbie van Baarle. Differential Characteristics of Cytotoxic T Lymphocytes Restricted by the Protective HLA Alleles B*27 and B*57 in HIV-1 Infection. J. Acquir. Immune Defic. Syndr., 67(3):236-245, 1 Nov 2014. PubMed ID: 25171732. Show all entries for this paper.


Displaying record number 1982

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name Pol-IV9; RT-IV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 57288

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 55152

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Protease-RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, in vitro stimulation or selection
Experimental methods Other
Keywords kinetics

Notes

References

Wick2005 W. David Wick, Otto O. Yang, Lawrence Corey, and Steven G. Self. How Many Human Immunodeficiency Virus Type 1-Infected Target Cells Can a Cytotoxic T-Lymphocyte Kill? J. Virol., 79(21):13579-13586, Nov 2005. PubMed ID: 16227278. Show all entries for this paper.


Displaying record number 57396

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(464-473)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 58379

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country France, Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords drug resistance

Notes

References

Pacheco2011 Yovana Pacheco, Clotilde Allavena, Yannick Guilloux, Sandra M. Mueller-Schmucker, Angela G. Hueckelhoven, Elisabeth André-Garnier, François Cleon, Virginie Ferré, Audrey Rodallec, Eric Billaud, Thomas Harrer, François Raffi, and Dorian McIlroy. The Immune Response to the RT181-189 Epitope in HIV-1-Infected Patients Is Associated with Viral Sequence Polymorphism Flanking the Epitope. J. Clin. Immunol., 31(4):681-689, Aug 2011. PubMed ID: 21491096. Show all entries for this paper.


Displaying record number 58758

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(446-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name Pol-IV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 53862

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name POL
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country France
Experimental methods Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords responses in children, characterizing CD8+ T cells

Notes

References

Scott-Algara2005a Daniel Scott-Algara, Florence Buseyne, Françoise Porrot, Beatrice Corre, Nassima Bellal, Christine Rouzioux, Stephane Blanche, and Yves Riviere. Not All Tetramer Binding CD8+ T Cells Can Produce Cytokines and Chemokines Involved in the Effector Functions of Virus-Specific CD8+ T Lymphocytes in HIV-1 Infected Children. J. Clin. Immunol., 25(1):57-67, Jan 2005. PubMed ID: 15742158. Show all entries for this paper.


Displaying record number 500

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*02)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia

Notes

References

Woodberry1999 T. Woodberry, J. Gardner, L. Mateo, D. Eisen, J. Medveczky, I. A. Ramshaw, S. A. Thomson, R. A. Ffrench, S. L. Elliott, H. Firat, F. A. Lemonnier, and A. Suhrbier. Immunogenicity of a Human Immunodeficiency Virus (HIV) Polytope Vaccine. J. Virol., 73:5320-5325, 1999. PubMed ID: 10364278. Show all entries for this paper.


Displaying record number 58303

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(464-)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 520

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(468-476)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

vanderBurg1995 S. H. van der Burg, M. R. Klein, C. J. Van de Velde, W. M. Kast, F. Miedema, and C. J. Melief. Induction of a Primary Human Cytotoxic T Lymphocyte Response against a Novel Conserved Epitope in a Functional Sequence of HIV-1 Reverse Transcriptase. AIDS, 9:121-127, 1995. PubMed ID: 7536421. Show all entries for this paper.


Displaying record number 1474

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name P1
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, escape

Notes

References

Samri2000 A. Samri, G. Haas, J. Duntze, J. M. Bouley, V. Calvez, C. Katlama, and B. Autran. Immunogenicity of mutations induced by nucleoside reverse transcriptase inhibitors for human immunodeficiency virus type 1-specific cytotoxic T cells. J. Virol., 74(19):9306-12, Oct 2000. URL: http://jvi.asm.org/cgi/content/full/74/19/9306. PubMed ID: 10982378. Show all entries for this paper.


Displaying record number 54299

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords HAART, ART, responses in children, dendritic cells

Notes

References

Zhang2006 Zheng Zhang, Qing-xia Zhao, Jun-liang Fu, Jin-xia Yao, Yun He, Lei Jin, and Fu-sheng Wang. Characteristics of HIV-1-Specific CD8 T-Cell Responses and Their Role in Loss of Viremia in Children Chronically Infected with HIV-1 Undergoing Highly Active Antiretroviral Therapy. Chin. Med. J., 119(23):1949-1957, 5 Dec 2006. PubMed ID: 17199938. Show all entries for this paper.


Displaying record number 521

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Pogue1995 R. R. Pogue, J. Eron, J. A. Frelinger, and M. Matsui. Amino-Terminal Alteration of the HLA-A*0201-Restricted Human Immunodeficiency Virus Pol Peptide Increases Complex Stability and In Vitro Immunogenicity. Proc. Natl. Acad. Sci. U.S.A., 92:8166-8170, 1995. In this mutational study a substitution of 476 I to Y did not increase affinity but did increase complex stability with HLA-A*0201. The altered peptide (Y) provided a greater stimulation of wildtype pol-specific CTL response relative to the wildtype peptide (I), in three different seropositive individuals. PubMed ID: 7545295. Show all entries for this paper.


Displaying record number 1489

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol( LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords dendritic cells

Notes

References

Engelmayer2001 J. Engelmayer, M. Larsson, A. Lee, M. Lee, W. I. Cox, R. M. Steinman, and N. Bhardwaj. Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals. J. Virol., 75(5):2142-53, Mar 2001. URL: http://jvi.asm.org/cgi/content/full/75/5/2142. PubMed ID: 11160718. Show all entries for this paper.


Displaying record number 55363

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords binding affinity, immunodominance, dendritic cells

Notes

References

Schaubert2007 Keri L. Schaubert, David A. Price, Nicole Frahm, Jinzhu Li, Hwee L. Ng, Aviva Joseph, Elyse Paul, Biswanath Majumder, Velpandi Ayyavoo, Emma Gostick, Sharon Adams, Francesco M. Marincola, Andrew K. Sewell, Marcus Altfeld, Jason M. Brenchley, Daniel C. Douek, Otto O. Yang, Christian Brander, Harris Goldstein, and June Kan-Mitchell. Availability of a Diversely Avid CD8+ T Cell Repertoire Specific for the Subdominant HLA-A2-Restricted HIV-1 Gag p24(19-27) Epitope. J. Immunol., 178(12):7756-7766, 15 Jun 2007. PubMed ID: 17548613. Show all entries for this paper.


Displaying record number 1518

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

GeaBanacloche2000 J. C. Gea-Banacloche, S. A. Migueles, L. Martino, W. L. Shupert, A. C. McNeil, M. S. Sabbaghian, L. Ehler, C. Prussin, R. Stevens, L. Lambert, J. Altman, C. W. Hallahan, J. C. de Quiros, and M. Connors. Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors. J. Immunol., 165(2):1082-92, 15 Jul 2000. URL: http://www.jimmunol.org/v165n2/1082/1082-abs-frame.html. PubMed ID: 10878387. Show all entries for this paper.


Displaying record number 522

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA 023: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 55764

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country Canada, United States
Experimental methods Intracellular cytokine staining, Other, Proliferation, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Jones2008 R. Brad Jones, Lishomwa C. Ndhlovu, Jason D. Barbour, Prameet M. Sheth, Aashish R. Jha, Brian R. Long, Jessica C. Wong, Malathy Satkunarajah, Marc Schweneker, Joan M. Chapman, Gabor Gyenes, Bahareh Vali, Martin D. Hyrcza, Feng Yun Yue, Colin Kovacs, Aref Sassi, Mona Loutfy, Roberta Halpenny, Desmond Persad, Gerald Spotts, Frederick M. Hecht, Tae-Wook Chun, Joseph M. McCune, Rupert Kaul, James M. Rini, Douglas F. Nixon, and Mario A. Ostrowski. Tim-3 Expression Defines a Novel Population of Dysfunctional T Cells with Highly Elevated Frequencies in Progressive HIV-1 Infection. J. Exp. Med., 205(12):2763-2779, 24 Nov 2008. PubMed ID: 19001139. Show all entries for this paper.


Displaying record number 1640

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, rate of progression

Notes

References

Jin2000a X. Jin, G. Ogg, S. Bonhoeffer, J. Safrit, M. Vesanen, D. Bauer, D. Chen, Y. Cao, M. A. Demoitie, L. Zhang, M. Markowitz, D. Nixon, A. McMichael, and D. D. Ho. An antigenic threshold for maintaining human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. Mol Med, 6(9):803-9, Sep 2000. PubMed ID: 11071274. Show all entries for this paper.


Displaying record number 1701

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Appay2000 V. Appay, D. F. Nixon, S. M. Donahoe, G. M. Gillespie, T. Dong, A. King, G. S. Ogg, H. M. Spiegel, C. Conlon, C. A. Spina, D. V. Havlir, D. D. Richman, A. Waters, P. Easterbrook, A. J. McMichael, and S. L. Rowland-Jones. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med., 192(1):63-75, 3 Jul 2000. URL: http://www.jem.org/cgi/content/full/192/1/63. PubMed ID: 10880527. Show all entries for this paper.


Displaying record number 56142

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*0201)
Immunogen virus
Experimental methods  
Keywords immunotherapy, TCR usage

Notes

References

Joseph2008 Aviva Joseph, Jian Hua Zheng, Antonia Follenzi, Teresa Dilorenzo, Kaori Sango, Jaime Hyman, Ken Chen, Alicja Piechocka-Trocha, Christian Brander, Erik Hooijberg, Dario A. Vignali, Bruce D. Walker, and Harris Goldstein. Lentiviral Vectors Encoding Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Receptor Genes Efficiently Convert Peripheral Blood CD8 T Lymphocytes into Cytotoxic T Lymphocytes with Potent In Vitro and In Vivo HIV-1-Specific Inhibitory Activity. J. Virol., 82(6):3078-3089, Mar 2008. PubMed ID: 18184707. Show all entries for this paper.


Displaying record number 56185

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(498-)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Country Botswana, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.


Displaying record number 1835

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Ostrowski2000 M. A. Ostrowski, S. J. Justement, L. Ehler, S. B. Mizell, S. Lui, J. Mican, B. D. Walker, E. K. Thomas, R. Seder, and A. S. Fauci. The role of CD4+ T cell help and CD40 ligand in the in vitro expansion of HIV-1-specific memory cytotoxic CD8+ T cell responses. J. Immunol., 165(11):6133-41, 1 Dec 2000. URL: http://www.jimmunol.org/cgi/content/full/165/11/6133. PubMed ID: 11086046. Show all entries for this paper.


Displaying record number 57345

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen peptide-HLA interaction
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords dendritic cells

Notes

References

Huang2009 Xiao-Li Huang, Zheng Fan, LuAnn Borowski, and Charles R. Rinaldo. Multiple T-Cell Responses to Human Immunodeficiency Virus Type 1 Are Enhanced by Dendritic Cells. Clin. Vaccine Immunol., 16(10):1504-1516, Oct 2009. PubMed ID: 19692626. Show all entries for this paper.


Displaying record number 57515

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Tetramer binding
Keywords  

Notes

References

Brockman2009 Mark A. Brockman, Douglas S. Kwon, Daniel P. Tighe, David F. Pavlik, Pamela C. Rosato, Jennifer Sela, Filippos Porichis, Sylvie Le Gall, Michael T. Waring, Kristin Moss, Heiko Jessen, Florencia Pereyra, Daniel G. Kavanagh, Bruce D. Walker, and Daniel E. Kaufmann. IL-10 Is Up-Regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-Specific T Cells. Blood, 114(2):346-356, 9 Jul 2009. PubMed ID: 19365081. Show all entries for this paper.


Displaying record number 52172

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name RT2
Species (MHC/HLA) human, transgenic mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type HIV-1 peptide in filamentous bacteriophage major coat protein
Vaccine component RT

Notes

References

Guardiola2001 J. Guardiola, P. De Berardinis, R. Sartorius, C. Fanutti, R. N. Perham, and G. Del Pozzo. Phage Display of Epitopes from HIV-1 Elicits Strong Cytolytic Responses In Vitro and In Vivo. Adv. Exp. Med. Biol., 495:291-298, 2001. PubMed ID: 11774581. Show all entries for this paper.


Displaying record number 507

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords TCR usage

Notes

References

Wilson1998 J. D. Wilson, G. S. Ogg, R. L. Allen, P. J. Goulder, A. Kelleher, A. K. Sewell, C. A. O'Callaghan, S. L. Rowland-Jones, M. F. Callan, and A. J. McMichael. Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific. J. Exp. Med., 188(4):785-790, 1998. PubMed ID: 9705961. Show all entries for this paper.


Displaying record number 58002

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype C
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational epitope prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 52702

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Cytokine production, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords  

Notes

References

Dagarag2003 Mirabelle Dagarag, Hwee Ng, Rachel Lubong, Rita B. Effros, and Otto O. Yang. Differential Impairment of Lytic and Cytokine Functions in Senescent Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes. J. Virol., 77(5):3077-3083, Mar 2003. PubMed ID: 12584333. Show all entries for this paper.


Displaying record number 502

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Spiegel2000 H. M. Spiegel, G. S. Ogg, E. DeFalcon, M. E. Sheehy, S. Monard, P. A. Haslett, G. Gillespie, S. M. Donahoe, H. Pollack, W. Borkowsky, A. J. McMichael, and D. F. Nixon. Human Immunodeficiency Virus Type 1- and Cytomegalovirus-Specific Cytotoxic T Lymphocytes Can Persist at High Frequency for Prolonged Periods in the Absence of Circulating Peripheral CD4+ T Cells. J. Virol., 74:1018-1022, 2000. PubMed ID: 10623767. Show all entries for this paper.


Displaying record number 532

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Gray1999 C. M. Gray, J. Lawrence, J. M. Schapiro, J. D. Altman, M. A. Winters, M. Crompton, M. Loi, S. K. Kundu, M. M. Davis, and T. C. Merigan. Frequency of Class I HLA-Restricted Anti-HIV CD8+ T Cells in Individuals Receiving Highly Active Antiretroviral Therapy (HAART). J. Immunol., 162:1780-1788, 1999. PubMed ID: 9973442. Show all entries for this paper.


Displaying record number 52779

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods Tetramer binding
Keywords genital and mucosal immunity

Notes

References

Shacklett2003 Barbara L. Shacklett, Catherine A. Cox, Johan K. Sandberg, Neil H. Stollman, Mark A. Jacobson, and Douglas F. Nixon. Trafficking of Human Immunodeficiency Virus Type 1-Specific CD8+ T Cells to Gut-Associated Lymphoid Tissue During Chronic Infection. J. Virol., 77(10):5621-5631, May 2003. PubMed ID: 12719554. Show all entries for this paper.


Displaying record number 503

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, immunodominance

Notes

References

Sewell1999 A. K. Sewell, D. A. Price, H. Teisserenc, B. L. Booth, U. Gileadi, F. M. Flavin, J. Trowsdale, R. E. Phillips, and V. Cerundolo. IFN-gamma Exposes a Cryptic Cytotoxic T Lymphocyte Epitope in HIV-1 Reverse Transcriptase. J. Immunol., 162:7075-7079, 1999. PubMed ID: 10358150. Show all entries for this paper.


Displaying record number 504

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing

Notes

References

Loing2000 E. Loing, M. Andrieu, K. Thiam, D. Schorner, K. H. Wiesmuller, A. Hosmalin, G. Jung, and H. Gras-Masse. Extension of HLA-A*0201-Restricted Minimal Epitope by N epsilon-Palmitoyl-Lysine Increases the Life Span of Functional Presentation to Cytotoxic T Cells. J. Immunol., 164:900-907, 2000. PubMed ID: 10623838. Show all entries for this paper.


Displaying record number 53006

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317 MN)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, vaccine-induced immune responses, immunodominance, immunotherapy

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain B clade MN
Vaccine component gp120, Protease, RT
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Isaguliants2004 Maria G. Isaguliants, Bartek Zuber, Andreas Boberg, Dan Sjöstrand, Sergey V. Belikov, Erik Rollman, Anne Kjerrström Zuber, Vladimir O. Rechinsky, Ann-Sofie Rytting, Clas F. R. Källander, Jorma Hinkula, Sergey N. Kochetkov, Margaret Liu, and Britta Wahren. Reverse Transcriptase-Based DNA Vaccines against Drug-Resistant HIV-1 Tested in a Mouse Model. Vaccine, 22(13-14):1810-1819, 16 Apr 2004. PubMed ID: 15068865. Show all entries for this paper.


Displaying record number 53009

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Epitope Name IV9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, T-cell Elispot
Keywords epitope processing, escape, kinetics, variant cross-reactivity

Notes

References

Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.


Displaying record number 53011

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Gag
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords epitope processing, rate of progression, immunodominance, acute/early infection, dendritic cells, TCR usage, memory cells

Notes

References

Kan-Mitchell2004 June Kan-Mitchell, Brygida Bisikirska, Flossie Wong-Staal, Keri L. Schaubert, Melissa Bajcz, and Michal Bereta. The HIV-1 HLA-A2-SLYNTVATL Is a Help-Independent CTL Epitope. J. Immunol., 172(9):5249-5261, 1 May 2004. PubMed ID: 15100263. Show all entries for this paper.


Displaying record number 536

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) transgenic mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA

Notes

References

Ishioka1999 G. Y. Ishioka, J. Fikes, G. Hermanson, B. Livingston, C. Crimi, M. Qin, M. F. del Guercio, C. Oseroff, C. Dahlberg, J. Alexander, R. W. Chesnut, and A. Sette. Utilization of MHC Class I Transgenic Mice for Development of Minigene. J. Immunol., 162:3915-3925, 1999. PubMed ID: 10201910. Show all entries for this paper.


Displaying record number 516

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords binding affinity

Notes

References

Konya1997 J. Konya, G. Stuber, A. Bjorndal, E. M. Fenyo, and J. Dillner. Primary induction of human cytotoxic lymphocytes against a synthetic peptide of the human immunodeficiency virus type 1 protease. J. Gen. Virol., 78:2217-2224, 1997. PubMed ID: 9292009. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 538

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Brander1998 Christian Brander, Kelly E. Hartman, Alicja K. Trocha, Norman G. Jones, R. Paul Johnson, Bette Korber, Peggy Wentworth, Susan P. Buchbinder, Steve Wolinsky, Bruce D. Walker, and Spyros A. Kalams. Lack of Strong Immune Selection Pressure by the Immunodominant, HLA-A*0201-Restricted Cytotoxic T Lymphocyte Response in Chronic Human Immunodeficiency Virus-1 Infection. J. Clin. Invest., 101(11):2559-2566, 1 Jun 1998. PubMed ID: 9616227. Show all entries for this paper.


Displaying record number 539

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Ogg1999 G. S. Ogg, X. Jin, S. Bonhoeffer, P. Moss, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, A. Hurley, M. Markowitz, D. D. Ho, A. J. McMichael, and D. F. Nixon. Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy. J. Virol., 73:797-800, 1999. PubMed ID: 9847391. Show all entries for this paper.


Displaying record number 1228

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53443

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(468-476 IIIB)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name pol468-476
Subtype B
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen vaccine
Experimental methods Intracellular cytokine staining
Keywords epitope processing, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain B clade IIIB
Vaccine component Gag-Pol

Notes

References

Singh2004 Rana A K Singh and Michael A Barry. Repertoire and Immunofocusing of CD8 T Cell Responses Generated by HIV-1 gag-pol and Expression Library Immunization Vaccines. J. Immunol., 173(7):4387-4393, 1 Oct 2004. PubMed ID: 15383568. Show all entries for this paper.


Displaying record number 505

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(510-518)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type canarypox, vaccinia
Vaccine component Env, Gag, Nef, Pol

Notes

References

Larsson1999 M. Larsson, X. Jin, B. Ramratnam, G. S. Ogg, J. Engelmayer, M. A. Demoitie, A. J. McMichael, W. I. Cox, R. M. Steinman, D. Nixon, and N. Bhardwaj. A Recombinant Vaccinia Virus Based ELISPOT Assay Detects High Frequencies of Pol-Specific CD8 T Cells in HIV-1-Positive Individuals. AIDS, 13:767-777, 1999. PubMed ID: 10357375. Show all entries for this paper.


Displaying record number 1354

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection, in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

DelaCruz2000 C. S. Dela Cruz, R. Tan, S. L. Rowland-Jones, and B. H. Barber. Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications. Int. Immunol., 12(9):1293-302, Sep 2000. URL: http://intimm.oupjournals.org/cgi/content/full/12/9/1293. PubMed ID: 10967024. Show all entries for this paper.


Displaying record number 53608

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*0301, B*3501, B*51, Cw*04, Cw*06
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords acute/early infection

Notes

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 519

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(468-476)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

vanderBurg1996 S. H. van der Burg, M. J. W. Visseren, R. M. P. Brandt, W. M. Kast, and C. J. M. Melief. Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability. J. Immunol., 156:3308-3314, 1996. Peptide-MHC dissociation rate is highly correlated with immunogenicity. In this study, HLA-A*0201 restricted epitopes from HPV, HBV and HIV were studied, some in the context of immunogenicity in peptide immunized HLA-A*0201/K$^b$ transgenic mice. PubMed ID: 8617954. Show all entries for this paper.


Displaying record number 53796

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name I9V
Species (MHC/HLA) transgenic mouse(A*0201)
Immunogen vaccine
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords memory cells, vaccine antigen design, characterizing CD8+ T cells

Vaccine Details

Vaccine type measles virus (MV)
Vaccine strain multiple epitope immunogen
Vaccine component gp140, gp140ΔV3

Notes

References

Lorin2005a Clarisse Lorin, Frédéric Delebecque, Valérie Labrousse, Lucie Da Silva, François Lemonnier, Michel Brahic, and Frédéric Tangy. A Recombinant Live Attenuated Measles Vaccine Vector Primes Effective HLA-A0201-Restricted Cytotoxic T Lymphocytes and Broadly Neutralizing Antibodies against HIV-1 Conserved Epitopes. Vaccine, 23(36):4463-4472, 22 Aug 2005. PubMed ID: 15993518. Show all entries for this paper.


Displaying record number 52577

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing, dendritic cells

Notes

References

Andrieu2003 Muriel Andrieu, Jean-François Desoutter, Estelle Loing, Jésintha Gaston, Daniel Hanau, Jean-Gérard Guillet, and Anne Hosmalin. Two Human Immunodeficiency Virus Vaccinal Lipopeptides Follow Different Cross-Presentation Pathways in Human Dendritic Cells. J. Virol., 77(2):1564-1570, Jan 2003. PubMed ID: 12502869. Show all entries for this paper.


Displaying record number 501

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords acute/early infection

Notes

References

Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.


Displaying record number 52704

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name I9V
Subtype B
Species (MHC/HLA) transgenic mouse(A*0201)
Immunogen vaccine
Experimental methods Chromium-release assay, Cytokine production, Intracellular cytokine staining, Tetramer binding
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine component RT
Adjuvant CpG immunostimulatory sequence (ISS)

Notes

References

Daftarian2003 Pirouz Daftarian, Saima Ali, Rahul Sharan, Simon F. Lacey, Corinna La Rosa, Jeff Longmate, Christopher Buck, Robert F. Siliciano, and Don J. Diamond. Immunization with Th-CTL Fusion Peptide and Cytosine-Phosphate-Guanine DNA in Transgenic HLA-A2 Mice Induces Recognition of HIV-Infected T Cells and Clears Vaccinia Virus Challenge. J. Immunol., 171(8):4028-4039, Oct 2003. PubMed ID: 14530323. Show all entries for this paper.


Displaying record number 58640

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name Pol464-472
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen peptide-HLA interaction
Country United States
Experimental methods Chromium-release assay
Keywords enhancing activity

Notes

References

Dupuis1997 M. Dupuis, M. V. Peshwa, C. Benike, S.K> Kundu, E. G. Engleman, W. C. Van Schooten, and T. C. Merigan. Allogeneic Dendritic Cell Induction of HIV-Specific Cytotoxic T Lymphocyte Responses from T Cells of HIV Type 1-Infected and Uninfected Individuals. AIDS Res. Hum. Retroviruses, 13:33-39, 1997. The potential benefit of T cell-based vaccination for HIV-1 infection remains to be determined. Cytotoxic T lymphocytes (CTLs) appear to clear substantial populations of HIV-1 virus in vivo, although CTL activity may contribute to the decline in CD4+ T cell count observed in the course of the disease. To investigate further the role of specific CTL responses in the control of HIV-1 replication, we raised primary CTL lines against a panel of conserved HIV-1 epitopes using blood-derived dendritic cells as antigen-presenting cells (APCs). Specific primary human CTL responses were induced against HLA-A*0201-restricted peptides with dendritic cells from HIV-1-seronegative donors. This method of immunization elicited cytotoxic activities capable of recognizing endogenously processed antigen. The CTL induction protocol was extended in order to explore the capacity of HLA-matched allogeneic dendritic cells to evoke novel CTL responses in T cells from an HIV-seropositive asymptomatic individual. Allogeneic peptide-pulsed dendritic cells from a healthy sibling were capable of eliciting a CTL response directed against an HIV epitope (env814: SLLNATDIAV) that was initially not detected in the CTL effector population of the HIV-1- infected patient. The possibility of manipulating CTL specificity directed against multiple conserved HIV-1 epitopes represents a significant step in the evaluation of T cell-based vaccination for treatment of disease. PubMed ID: 8989425. Show all entries for this paper.


Displaying record number 59172

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name pol 476-484
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 508

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 52265

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing, immunodominance

Notes

References

Sewell2002 Andrew K. Sewell, Bruce L. Booth, Jr., Vincenzo Cerundolo, Rodney E. Phillips, and David A. Price. Differential Processing of HLA A2-Restricted HIV Type 1 Cytotoxic T Lymphocyte Epitopes. Viral Immunol., 15(1):193-196, 2002. PubMed ID: 11952141. Show all entries for this paper.


Displaying record number 52284

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IL-9
Species (MHC/HLA) humanized mouse(A*0201)
Immunogen HIV-1 infected monocyte-derived
Experimental methods  
Keywords  

Notes

References

Poluektova2002 Larisa Y. Poluektova, David H. Munn, Yuri Persidsky, and Howard E. Gendelman. Generation of Cytotoxic T Cells Against Virus-Infected Human Brain Macrophages in a Murine Model of HIV-1 Encephalitis. J. Immunol., 168(8):3941-3949, 15 Apr 2002. PubMed ID: 11937550. Show all entries for this paper.


Displaying record number 509

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Gray1999 C. M. Gray, J. Lawrence, J. M. Schapiro, J. D. Altman, M. A. Winters, M. Crompton, M. Loi, S. K. Kundu, M. M. Davis, and T. C. Merigan. Frequency of Class I HLA-Restricted Anti-HIV CD8+ T Cells in Individuals Receiving Highly Active Antiretroviral Therapy (HAART). J. Immunol., 162:1780-1788, 1999. PubMed ID: 9973442. Show all entries for this paper.


Displaying record number 52291

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name LR22
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords binding affinity, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), Montanide (ISA 720), P30, PLG

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.


Displaying record number 52292

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name LR22
Subtype B
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type peptide
Vaccine strain B clade LAI
Adjuvant Incomplete Freund's Adjuvant (IFA), IL-12, P30

Notes

References

Peter2001 Katrin Peter, Ying Men, Giuseppe Pantaleo, Bruno Gander, and Giampietro Corradin. Induction of a Cytotoxic T-Cell Response to HIV-1 Proteins with Short Synthetic Peptides and Human Compatible Adjuvants. Vaccine, 19(30):4121-4129, 20 Jul 2001. PubMed ID: 11457536. Show all entries for this paper.

Peter2002 Katrin Peter, Michael J. Brunda, and Giampietro Corradin. IL-12 Administration Leads to a Transient Depletion of T Cells, B Cells, and APCs and Concomitant Abrogation of the HLA-A2.1-Restricted CTL Response in Transgenic Mice. J. Immunol., 169(1):63-67, 1 Jul 2002. PubMed ID: 12077229. Show all entries for this paper.


Displaying record number 526

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altman1996 J. D. Altman, P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. Phenotypic analysis of antigen-specific T lymphocytes. Science, 274:94-6, 1996. Comments in Science 1998 Jun 19;280(5371):1821. PubMed ID: 8810254. Show all entries for this paper.


Displaying record number 510

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Ogg1998 G. S. Ogg, X. Jin, S. Bonhoeffer, P. R. Dunbar, M. A. Nowak, S. Monard, J. P. Segal, Y. Cao, S. L. Rowland-Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. D. Ho, D. F. Nixon, and A. J. McMichael. Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA. Science, 279:2103-2106, 1998. PubMed ID: 9516110. Show all entries for this paper.


Displaying record number 528

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Walter1997 J. B. Walter, C. Brander, M. Mammen, D. N. Garboczi, S. A. Kalams, G. M. Whiteside, B. D. Walker, and H. N. Eisen. Stimulation of Human Cytotoxic T Cells with HIV-1-Derived Peptides Presented by Recombinant HLA-A2 Peptide Complexes. Int. Immunol., 9:451-459, 1997. HLA-A2 heavy chain and beta 2-microglobulin refolded in the presence of peptides became susceptible to lysis by HLA-A2-restricted cytotoxic T lymphocyte (CTL) clones specific for the peptides. Recombinant HLA-A2 peptide complexes covalently immobilized on microspheres stimulated the development of HLA-A2 peptide-specific CTL. PubMed ID: 9088983. Show all entries for this paper.


Displaying record number 52346

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) transgenic mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords binding affinity, vaccine-induced immune responses

Vaccine Details

Vaccine type peptide
Vaccine component RT
Adjuvant Complete Freund's Adjuvant (CFA)

Notes

References

Boissonnas2002 Alexandre Boissonnas, Olivia Bonduelle, Ariane Antzack, Yu-Chun Lone, Cecile Gache, Patrice Debre, Brigitte Autran, and Behazine Combadiere. In Vivo Priming Of HIV-Specific CTLs Determines Selective Cross-Reactive Immune Responses Against Poorly Immunogenic HIV-Natural Variants. J. Immunol., 169(7):3694-3699, 1 Oct 2002. PubMed ID: 12244162. Show all entries for this paper.


Displaying record number 52354

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(468-476)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) mouse(A*0201)
Immunogen vaccine
Experimental methods  
Keywords epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA
Vaccine component HIV-1

Notes

References

Singh2002 Rana A. K. Singh, Lei Wu, and Michael A. Barry. Generation of Genome-Wide CD8 T Cell Responses in HLA-A*0201 Transgenic Mice by an HIV-1 Ubiquitin Expression Library Immunization Vaccine. J. Immunol., 168(1):379-391, 1 Jan 2002. PubMed ID: 11751984. Show all entries for this paper.

Sykes1999 Kathryn F. Sykes and Stephen Albert Johnston. Genetic live vaccines mimic the antigenicity but not pathogenicity of live viruses. DNA Cell Biol., 18(7):521-531, Jul 1999. PubMed ID: 10433551. Show all entries for this paper.


Displaying record number 52439

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype A, B, C, D
Species (MHC/HLA) human, macaque(A*0201)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 511

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia

Notes

References

Hanke1998b T. Hanke, T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith, and A. McMichael. Immunogenicities of Intravenous and Intramuscular Administrations of Modified Vaccinia Virus Ankara-Based Multi-CTL Epitope Vaccine for Human Immunodeficiency Virus Type 1 in Mice. J. Gen. Virol., 79:83-90, 1998. PubMed ID: 9460927. Show all entries for this paper.

Hanke1998c T. Hanke, J. Schneider, S. G. Gilbert, A. V. S. Hill, and A. McMichael. DNA Multi-CTL Epitope Vaccines for HIV and Plasmodium falciparum: Immunogenicity in Mice. Vaccine, 16:426-435, 1998. PubMed ID: 9607066. Show all entries for this paper.


Displaying record number 1495

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name P1
Subtype B
Species (MHC/HLA) human(A*0201, A*0205)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 1427

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201, A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.


Displaying record number 535

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol( subtype B)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*0202, A2)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons

Notes

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.


Displaying record number 54880

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 506

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, TCR usage

Notes

References

Kolowos1999 W. Kolowos, M. Schmitt, M. Herrman, E. Harrer, P. Low, J. R. Kalden, and T. Harrer. Biased TCR Repertoire in HIV-1-Infected Patients Due to Clonal Expansion of HIV-1-Reverse Transcriptase-Specific CTL Clones. J. Immunol., 162:7525-7533, 1999. PubMed ID: 10358208. Show all entries for this paper.


Displaying record number 512

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Collins1998 K. L. Collins, B. K. Chen, S. A. Kalams, B. D. Walker, and D. Baltimore. HIV-1 Nef Protein Protects Infected Primary Cells against Killing by Cytotoxic T Lymphocytes. Nature, 391:397-401, 1998. PubMed ID: 9450757. Show all entries for this paper.


Displaying record number 513

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Fan1997 Z. Fan, X. L. Huang, L. Zheng, C. Wilson, L. Borowski, J. Liebmann, P. Gupta, J. Margolick, and C. Rinaldo. Cultured Blood Dendritic Cells Retain HIV-1 Antigen-Presenting Capacity for Memory CTL During Progressive HIV-1 Infection. J. Immunol., 159:4973-4982, 1997. PubMed ID: 9366424. Show all entries for this paper.


Displaying record number 514

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords dendritic cells

Notes

References

Kundu1998 S. K. Kundu, E. Engleman, C. Benike, M. H. Shapero, M. Dupuis, W. C. van Schooten, M. Eibl, and T. C. Merigan. A Pilot Clinical Trial of HIV Antigen-Pulsed Allogeneic and Autologous Dendritic Cell Therapy in HIV-Infected Patients. AIDS Res. Hum. Retroviruses, 14:551-560, 1998. PubMed ID: 9591709. Show all entries for this paper.


Displaying record number 515

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tsomides1994 T. J. Tsomides, A. Aldovini, R. P. Johnson, B. D. Walker, R. A. Young, and H. N. Eisen. Naturally Processed Viral Peptides Recognized by Cytotoxic T Lymphocytes on Cells Chronically Infected by Human Immunodeficiency Virus Type 1. J. Exp. Med., 180:1283-1293, 1994. Naturally processed peptides can be purified from trifluoroacetic acid lysates of HIV-1 infected cells. A gag and RT epitope were compared; both synthetic peptides are optimally active in CTL assays. The naturally processed gag peptide was more abundant than the RT peptide in HIV-1 infected HLA-A2 positive cells, and the gag specific CTL more effective, suggesting surface density of peptides may influence efficiency of CTL killing. PubMed ID: 7523570. Show all entries for this paper.


Displaying record number 517

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 518

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 523

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Yang1996 O. O. Yang, S. A. Kalams, M. Rosenzweig, A. Trocha, N. Jones, M. Koziel, B. D. Walker, and R. P. Johnson. Efficient Lysis of Human Immunodeficiency Virus Type 1-Infected Cells by Cytotoxic T Lymphocytes. J. Virol., 70:5799-5806, 1996. PubMed ID: 8709196. Show all entries for this paper.


Displaying record number 524

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords  

Notes

References

Yang1997 O. O. Yang, S. A. Kalams, A. Trocha, H. Cao, A. Luster, R. P. Johnson, and B. D. Walker. Suppression of Human Immunodeficiency Virus Type 1 Replication by CD8+ Cells: Evidence for HLA Class I-Restricted Triggering of Cytolytic and Noncytolytic Mechanisms. J. Virol., 71:3120-3128, 1997. Although CD8+ lymphocytes in human immunodeficiency virus type 1 (HIV-1)-infected individuals have been demonstrated to suppress viral replication, the mechanisms of inhibition have not been defined precisely. A large body of evidence indicates that these cells act via soluble inhibitory factors, but the potential role of HLA class I-restricted cytolysis has remained controversial. Here we demonstrate that HIV-1-specific cytotoxic T lymphocytes (CTL) mediate antiviral suppression by both cytolytic and noncytolytic mechanisms. The predominant mechanism requires direct contact of CTL with the infected cells, is HLA class I restricted, and can achieve complete elimination of detectable virus in infected cell cultures. Inhibition occurs even at high multiplicities of infection or at ratios of CTL to CD4 cells as low as 1:1,000. The other mechanism is mediated by soluble inhibitory factors which are triggered in an antigen-specific and HLA-restricted fashion but then act without HLA restriction. PubMed ID: 9060675. Show all entries for this paper.


Displaying record number 525

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords TCR usage

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Moss1995 P. A. H. Moss, S. L. Rowland-Jones, P. M. Frodsham, S. McAdam, P. Giangrande, A. McMichael, and J. I. Bell. Persistent High Frequency of Human Immunodeficiency Virus-Specific Cytotoxic T Cells in Peripheral Blood of Infected Donors. Proc. Natl. Acad. Sci. U.S.A., 92:5773-5777, 1995. PubMed ID: 7597028. Show all entries for this paper.


Displaying record number 527

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Musey1997 L. Musey, Y. Hu, L. Eckert, M. Christensen, T. Karchmer, and M. J. McElrath. HIV-1 Induces Cytotoxic T Lymphocytes in the Cervix of Infected Women. J. Exp. Med., 185:293-303, 1997. Mononuclear cells in cytobrush specimens from the cervical samples were stimulated with antigen. Eight women with CD4 positive counts $>=$ 500 cells/$\mu$l had HIV-1-specific CTL, but only 4/11 with counts $<$ 500 cells/$\mu$l had HIV-1-specific CTL responses. PubMed ID: 9016878. Show all entries for this paper.


Displaying record number 529

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tsomides1991 T. J. Tsomides, B. D. Walker, and H. N. Eisen. An Optimal Viral Peptide Recognized by CD8+ T Cells Binds Very Tightly to the Restricting Class I Major Histocompatibility Complex Protein on Intact Cells but Not to the Purified Class I Protein. Proc. Natl. Acad. Sci. U.S.A., 88:11276-11280, 1991. PubMed ID: 1722325. Show all entries for this paper.


Displaying record number 530

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Connan1994 F. Connan, F. Hlavac, J. Hoebeke, J. G. Guillet, and J. Choppin. A Simple Assay for Detection of Peptides Promoting the Assembly of HLA Class I Molecules. Eur. J. Immunol., 24:777-780, 1994. Peptides from influenza and HIV-1 were tested for their ability to promote the assembly of HLA-A2 and HLA-B51 molecules in T2 cell lysates. HIV Pol 476-484 allowed significant assembly of HLA-A2, and is a target for CTL. Nef peptide 186-194 produced significant assembly of HLA-B51. A hydrophobic anchor residue (V, L, I) at position 9 could occupy pocket F, and a hydrophobic residue (V, L) at position 3 or 4 may anchor to hydrophobic pocket D of HLA-B51. Proline at position 2 increases HLA-B51 anchoring. PubMed ID: 8125145. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 531

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(510-518)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords  

Notes

References

Parker1992 K. C. Parker, M. A. Bednarek, L. K. Hull, U. Utz, B. Cunningham H. J. Zweerink, W. E. Biddison, and J. E. Coligan. Sequence Motifs Important for Peptide Binding to the Human MHC Class I Molecule, HLA-A2. J. Immunol., 149, 1992. PubMed ID: 1331239. Show all entries for this paper.


Displaying record number 533

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Dyer1999 W. B. Dyer, G. S. Ogg, M. A. Demoitie, X. Jin, A. F. Geczy, S. L. Rowland-Jones, A. J. McMichael, D. F. Nixon, and J. S. Sullivan. Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected with nef-Defective HIV Type 1. J. Virol., 73:436-443, 1999. PubMed ID: 9847349. Show all entries for this paper.


Displaying record number 534

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords dendritic cells

Notes

References

Zarling1999 A. L. Zarling, J. G. Johnson, R. W. Hoffman, and D. R. Lee. Induction of Primary Human CD8+ T Lymphocyte Responses In Vitro Using Dendritic Cells. J. Immunol., 162:5197-5204, 1999. PubMed ID: 10227993. Show all entries for this paper.


Displaying record number 537

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(480-)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) (A2)
Immunogen computer prediction
Experimental methods Other
Keywords subtype comparisons, computational epitope prediction

Notes

References

Schafer1998 J. R. Schafer, B. M. Jesdale, J. A. George, N. M. Kouttab, and A. S. De Groot. Prediction of Well-Conserved HIV-1 Ligands Using a Matrix-Based Algorithm, EpiMatrix. Vaccine, 16:1880-1884, 1998. PubMed ID: 9795396. Show all entries for this paper.


Displaying record number 1313

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name RT IV9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 1346

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name RT2
Species (MHC/HLA) human, transgenic mouse(A2)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods  
Keywords epitope processing

Vaccine Details

Vaccine type HIV-1 peptide in filamentous bacteriophage major coat protein
Vaccine component RT

Notes

References

DeBerardinis2000 P. De Berardinis, R. Sartorius, C. Fanutti, R. N. Perham, G. Del Pozzo, and J. Guardiola. Phage Display of Peptide Epitopes from HIV-1 Elicits Strong Cytolytic Responses. Nat. Biotechnol., 18(8):873-876, Aug 2000. PubMed ID: 10932158. Show all entries for this paper.


Displaying record number 1369

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name ILK
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI), immunodominance, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 1407

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Kostense2001 S. Kostense, G. S. Ogg, E. H. Manting, G. Gillespie, J. Joling, K. Vandenberghe, E. Z. Veenhof, D. van Baarle, S. Jurriaans, M. R. Klein, and F. Miedema. High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur. J. Immunol., 31(3):677-86, Mar 2001. PubMed ID: 11241270. Show all entries for this paper.


Displaying record number 1483

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, immunodominance

Notes

References

Seth2001 A. Seth, J. Markee, A. Hoering, A. Sevin, D. E. Sabath, J. E. Schmitz, M. J. Kuroda, M. A. Lifton, M. S. Hirsch, A. C. Collier, N. L. Letvin, and M. J. McElrath. Alterations in T cell phenotype and human immunodeficiency virus type 1-specific cytotoxicity after potent antiretroviral therapy. J. Infect. Dis., 183(5):722-9, 1 Mar 2001. PubMed ID: 11181148. Show all entries for this paper.


Displaying record number 1520

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 SF2)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52177

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, epitope processing

Notes

References

Kelleher2001a A. D. Kelleher, B. L. Booth, Jr., A. K. Sewell, A. Oxenius, V. Cerundolo, A. J. McMichael, R. E. Phillips, and D. A. Price. Effects of Retroviral Protease Inhibitors on Proteasome Function and Processing of HIV-Derived MHC Class I-Restricted Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 17(11):1063-1066, 20 Jul 2001. PubMed ID: 11485623. Show all entries for this paper.


Displaying record number 52237

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 NL43)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef

Notes

References

Yang2002 Xinzhen Yang, Juliette Lee, Erin M. Mahony, Peter D. Kwong, Richard Wyatt, and Joseph Sodroski. Highly Stable Trimers Formed by Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Fused with the Trimeric Motif of T4 Bacteriophage Fibritin. J. Virol., 76(9):4634-4642, May 2002. PubMed ID: 1932429. Show all entries for this paper.


Displaying record number 52286

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 BRU)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2
Experimental methods  
Keywords epitope processing

Notes

References

Cohen2002 W. M. Cohen, A. Bianco, F. Connan, L. Camoin, M. Dalod, G. Lauvau, E. Ferriés, B. Culmann-Penciolelli, P. M. van Endert, J. P. Briand, J. Choppin, and J. G. Guillet. Study of Antigen-Processing Steps Reveals Preferences Explaining Differential Biological Outcomes of Two HLA-A2-Restricted Immunodominant Epitopes from Human Immunodeficiency Virus Type 1. J. Virol., 76(20):10219-10225, Oct 2002. PubMed ID: 12239297. Show all entries for this paper.


Displaying record number 52305

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name p9
Species (MHC/HLA) mouse(A2)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide
Adjuvant Complete Freund's Adjuvant (CFA)

Notes

References

DeLucca2002 Fernando L. De Lucca, Valeria S. F. Sales, Liliana R. Souza, and Maria Angelica E. Watanabe. Evidence for the Involvement of the RNA-Dependent Protein Kinase (PKR) in the Induction of Human Cytotoxic T Lymphocytes against a Synthetic Peptide of HIV-1 by Regulatory RNA. Mol Cell Biochem, 238(1-2):19-26, Sep 2002. PubMed ID: 12349906. Show all entries for this paper.


Displaying record number 52315

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name ILK
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 52339

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location p51(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) mouse(A2)
Immunogen vaccine
Patient MHC/HLA H2-Kb
Experimental methods  
Keywords  

Vaccine Details

Vaccine strain B clade IIIB
Vaccine component Gag, Pol
Adjuvant IL-12

Notes

References

Kmieciak2001 Dariusz Kmieciak, Elizabeth Bolesta, Toshio Naito, Jaroslaw Gzyl, Yutaro Kaneko, and Danuta Kozbor. Enhancement of Cellular and Humoral Immune Responses to Human Immunodeficiency Virus Type 1 Gag and Pol by a G/P-92 Fusion Protein Expressing Highly Immunogenic Gag p17/p24 and Pol p51 Antigens. J Hum Virol, 4(6):306-316, Nov-Dec 2001. PubMed ID: 12082397. Show all entries for this paper.


Displaying record number 52518

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317 NL-43)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef, escape

Notes

References

Ali2003 Ayub Ali, Satish Pillai, Hwee Ng, Rachel Lubong, Douglas D. Richman, Beth D. Jamieson, Yan Ding, M. Juliana McElrath, John C. Guatelli, and Otto O. Yang. Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations. J. Immunol., 171(8):3999-4005, Oct 2003. PubMed ID: 14530319. Show all entries for this paper.


Displaying record number 52695

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name Pol476
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational epitope prediction

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 52706

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name RT2
Subtype B
Species (MHC/HLA) transgenic mouse(A2)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine component RT
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Domingo2003 Gonzalo J. Domingo, Antonella Caivano, Rossella Sartorius, Pasquale Barba, Malin Bäckström, Dominique Piatier-Tonneau, John Guardiola, Piergiuseppe De Berardinis, and Richard N Perham. Induction of Specific T-Helper and Cytolytic Responses to Epitopes Displayed on a Virus-Like Protein Scaffold Derived from the Pyruvate Dehydrogenase Multienzyme Complex. Vaccine, 21(13-14):1502-1509, 28 Mar 2003. PubMed ID: 12615447. Show all entries for this paper.


Displaying record number 52776

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords responses in children

Notes

References

Sandberg2003 Johan K. Sandberg, Noam M. Fast, Kimberly A. Jordan, Scott N. Furlan, Jason D. Barbour, Glenn Fennelly, Joanna Dobroszycki, Hans M. L. Spiegel, Andrew Wiznia, Michael G. Rosenberg, and Douglas F. Nixon. HIV-Specific CD8+ T Cell Function in Children witH Vertically Acquired HIV-1 Infection is Critically Influenced by Age and the State of the CD4+ T Cell Compartment. J. Immunol., 170(8):4403-4410, Apr 2003. PubMed ID: 12682278. Show all entries for this paper.


Displaying record number 52781

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) (A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B27, B51; A2, A3, B27, B57; A2, A23, B57
Experimental methods CD8 T-cell Elispot - IFNγ, Cytokine production, Intracellular cytokine staining, Tetramer binding
Keywords assay or method development, memory cells

Notes

References

Sun2003 Y. Sun, E. Iglesias, A. Samri, G. Kamkamidze, T. Decoville, G. Carcelain, and B. Autran. A Systematic Comparison of Methods to Measure HIV-1 Specific CD8 T Cells. J. Immunol. Methods, 272(1-2):23-34, 15 Jan 2003. PubMed ID: 12505709. Show all entries for this paper.


Displaying record number 52787

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317 NL43)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication, Chromium-release assay
Keywords escape

Notes

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.


Displaying record number 53035

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Koning2004 Fransje A. Koning, Christine A. Jansen, Jos Dekker, Richard A. Kaslow, Nicole Dukers, Debbie van Baarle, Maria Prins, and Hanneke Schuitemaker. Correlates of Resistance to HIV-1 Infection in Homosexual Men with High-Risk Sexual Behaviour. AIDS, 18(8):1117-1126, 21 May 2004. PubMed ID: 15166527. Show all entries for this paper.


Displaying record number 53152

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name RT-IV9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords binding affinity, TCR usage, characterizing CD8+ T cells

Notes

References

Yang2003a Otto O. Yang, Phuong T. Nguyen Sarkis, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL. J. Immunol., 171(7):3718-3724, 1 Oct 2003. PubMed ID: 14500671. Show all entries for this paper.


Displaying record number 53355

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location ( B consensus)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A3, B62, B8, Cw10, Cw7
Country United States
Experimental methods Chromium-release assay, Cytokine production, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords assay or method development, memory cells, characterizing CD8+ T cells

Notes

References

Lichterfeld2004b Mathias Lichterfeld, Xu G. Yu, Michael T. Waring, Stanley K. Mui, Mary N. Johnston, Daniel Cohen, Marylyn M. Addo, John Zaunders, Galit Alter, Eunice Pae, Daryld Strick, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. HIV-1-Specific Cytotoxicity Is Preferentially Mediated by a Subset of CD8+ T Cells Producing both Interferon-gamma and Tumor Necrosis Factor-alpha. Blood, 104(2):487-394, 15 Jul 2004. PubMed ID: 15059848. Show all entries for this paper.


Displaying record number 53388

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords assay or method development

Notes

References

Lubong2004 Rachel Lubong, Hwee L. Ng, Christel H. Uittenbogaart, and Otto O. Yang. Culturing of HIV-1-Specific Cytotoxic T Lymphocytes with Interleukin-7 and Interleukin-15. Virology, 325(2):175-180, 1 Aug 2004. PubMed ID: 15246257. Show all entries for this paper.


Displaying record number 53398

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative
Patient MHC/HLA A*02, A*30, B*15, B*4402
Experimental methods T-cell Elispot, Tetramer binding
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Missale2004 Gabriele Missale, Laura Papagno, Amalia Penna, Massimo Pilli, Alessandro Zerbini, Piero Vitali, Giovanni Pieroni, Simona Urbani, Jacopo Uggeri, Susana Pinheiro, Sarah Rowland-Jones, and Carlo Ferrari. Parenteral Exposure to High HIV Viremia Leads to Virus-Specific T Cell Priming without Evidence of Infection. Eur. J. Immunol., 34(11):3208-3215, Nov 2004. PubMed ID: 15459901. Show all entries for this paper.


Displaying record number 53402

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods Intracellular cytokine staining, T-cell Elispot, Tetramer binding
Keywords rate of progression, acute/early infection, characterizing CD8+ T cells

Notes

References

Papagno2004 Laura Papagno, Celsa A. Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J. McMichael, Douglas D. Richman, Sarah L. Rowland-Jones, and Victor Appay. Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol., 2(2):E20, Feb 2004. PubMed ID: 14966528. Show all entries for this paper.


Displaying record number 53460

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location (309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name RT2
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type bacteriophage coat protein, dihydrolipoyl acetyltransferase E2 protein, of Bacillus stearothermophilus
Vaccine component RT

Notes

References

DeBerardinis2003 Piergiuseppe De Berardinis, Rossella Sartorius, Antonella Caivano, Dina Mascolo, Gonzalo J. Domingo, Giovanna Del Pozzo, Muriel Gaubin, Richard N. Perham, Dominique Piatier-Tonneau, and John Guardiola. Use of Fusion Proteins and Procaryotic Display Systems for Delivery of HIV-1 Antigens: Development of Novel Vaccines for HIV-1 Infection. Curr. HIV Res., 1(4):441-446, Oct 2003. PubMed ID: 15049429. Show all entries for this paper.


Displaying record number 53500

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 53588

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 53708

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, variant cross-reactivity, optimal epitope

Notes

References

Harrer2005b Ellen G. Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M. Müller, Bernd M. Spriewald, and Thomas Harrer. A Conserved HLA B13-Restricted Cytotoxic T Lymphocyte Epitope in Nef is a Dominant Epitope in HLA B13-Positive HIV-1-Infected Patients. AIDS, 19(7):734-735, 29 Apr 2005. PubMed ID: 15821402. Show all entries for this paper.


Displaying record number 53719

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484 BRU)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B, CRF02_AG
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 53803

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(77-85)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IL9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Country Canada
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HIV exposed persistently seronegative (HEPS), immunodominance, genital and mucosal immunity, characterizing CD8+ T cells

Notes

References

Makedonas2005a George Makedonas, Julie Bruneau, Michel Alary, Christos M. Tsoukas, Catherine M. Lowndes, François Lamothe, and Nicole F. Bernard. Comparison of HIV-Specific CD8 T-Cell Responses among Uninfected Individuals Exposed to HIV Parenterally and Mucosally. AIDS, 19(3):251-259, 18 Feb 2005. PubMed ID: 15718835. Show all entries for this paper.


Displaying record number 53859

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, TCR usage, characterizing CD8+ T cells, optimal epitope

Notes

References

Schmitt-Haendle2005 Matthias Schmitt-Haendle, Oliver Bachmann, Ellen Harrer, Barbara Schmidt, Michael Bäuerle, and Thomas Harrer. Recognition Patterns of HLA-A2-Restricted Human Immunodeficiency Virus-1-Specific Cytotoxic T-Lymphocytes in a Cohort of HIV-1-Infected Individuals. Viral Immunol., 18(4):627-636, 2005. PubMed ID: 16359229. Show all entries for this paper.


Displaying record number 54231

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name A2-IV9(RT)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54759

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay, Other
Keywords binding affinity

Notes

References

Bennett2007 Michael S. Bennett, Hwee L. Ng, Mirabelle Dagarag, Ayub Ali, and Otto O. Yang. Epitope-Dependent Avidity Thresholds for Cytotoxic T-Lymphocyte Clearance of Virus-Infected Cells. J. Virol., 81(10):4973-4980, May 2007. PubMed ID: 17329324. Show all entries for this paper.


Displaying record number 55015

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55183

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Tetramer binding
Keywords responses in children, rate of progression

Notes

References

Chakraborty2005 Rana Chakraborty, Anne-Sophie Morel, Julian K. Sutton, Victor Appay, Ruth M. Ripley, Tao Dong, Tim Rostron, Simon Ogola, Tresa Palakudy, Rachel Musoke, Angelo D'Agostino, Mary Ritter, and Sarah L. Rowland-Jones. Correlates of Delayed Disease Progression in HIV-1-Infected Kenyan Children. J. Immunol., 174(12):8191-8199, 15 Jun 2005. PubMed ID: 15944328. Show all entries for this paper.


Displaying record number 55397

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Epitope Name Pol 476
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords immunodominance

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 55742

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name Pol498
Subtype B
Species (MHC/HLA) human(A2)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine component Other

Notes

References

Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.


Displaying record number 55751

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen peptide-HLA interaction
Experimental methods Chromium-release assay, Other
Keywords TCR usage

Notes

References

Hofmann2008 Christian Hofmann, Thomas Harrer, Verena Kubesch, Katja Maurer, Karin J. Metzner, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Gerold Schuler, Jan Dörrie, and Niels Schaft. Generation of HIV-1-Specific T Cells by Electroporation of T-Cell Receptor RNA. AIDS, 22(13):1577-1582, 20 Aug 2008. PubMed ID: 18670216. Show all entries for this paper.


Displaying record number 55846

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(464-472)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Switzerland
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords HAART, ART

Notes

References

Rehr2008 Manuela Rehr, Julia Cahenzli, Anna Haas, David A. Price, Emma Gostick, Milo Huber, Urs Karrer, and Annette Oxenius. Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy. J. Virol., 82(7):3391-404, Apr 2008. PubMed ID: 18199637. Show all entries for this paper.


Displaying record number 55907

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9(RT)
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 56063

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name Pol476
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 56140

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(309-317)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Show epitope variants
Epitope Name IV9
Subtype B
Species (MHC/HLA) human, transgenic mouse(A2)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords variant cross-reactivity

Vaccine Details

Vaccine type peptide
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Blondelle2008 Sylvie E. Blondelle, Rosa Moya-Castro, Keiko Osawa, Kim Schroder, and Darcy B. Wilson. Immunogenically Optimized Peptides Derived from Natural Mutants of HIV CTL Epitopes and Peptide Combinatorial Libraries. Biopolymers, 90(5):683-694, 2008. PubMed ID: 18481808. Show all entries for this paper.


Displaying record number 56728

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type peptide, polyepitope

Notes

References

Blondelle2009 Sylvie E. Blondelle, Rosa Moya, Kim Schroder, Keiko Osawa, and Darcy B. Wilson. Natural Mutants of HIV CTL Epitopes with Enhanced Immunogenicity as Potential Vaccine Candidates. Adv. Exp. Med. Biol., 611:379-382, 2009. PubMed ID: 19400233. Show all entries for this paper.


Displaying record number 57215

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords mother-to-infant transmission

Notes

References

Lohman-Payne2009 B. Lohman-Payne, J. A. Slyker, B. A. Richardson, C. Farquhar, M. Majiwa, E. Maleche-Obimbo, D. Mbori-Ngacha, J. Overbaugh, S. Rowland-Jones, and G. John-Stewart. Infants with Late Breast Milk Acquisition of HIV-1 Generate Interferon-gamma Responses More Rapidly than Infants with Early Peripartum Acquisition. Clin. Exp. Immunol., 156(3):511-517, Jun 2009. PubMed ID: 19438605. Show all entries for this paper.


Displaying record number 57627

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name ILK
Subtype A, B, C
Species (MHC/HLA) transgenic mouse(A2)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords epitope processing, vaccine antigen design

Vaccine Details

Vaccine type DNA prime with vaccinia boost, polyepitope
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Vpr

Notes

References

Bazhan2010 S. I. Bazhan, L. I. Karpenko, T. N. Ilyicheva, P. A. Belavin, S. V. Seregin, N. K. Danilyuk, D. V. Antonets, and A. A. Ilyichev. Rational Design Based Synthetic Polyepitope DNA Vaccine for Eliciting HIV-Specific CD8+ T Cell Responses. Mol Immunol, 47(7-8):1507-1515, Apr 2010. PubMed ID: 20189249. Show all entries for this paper.


Displaying record number 57827

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name IV9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 56510

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Epitope Name Pol498
Subtype A, B, C, D
Species (MHC/HLA) human, mouse(A2 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation

Notes

References

Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.


Displaying record number 1595

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A2 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 55096

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location  
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords binding affinity, acute/early infection

Notes

References

Lichterfeld2007 Mathias Lichterfeld, Xu G. Yu, Stanley K. Mui, Katie L. Williams, Alicja Trocha, Mark A. Brockman, Rachel L. Allgaier, Michael T. Waring, Tomohiko Koibuchi, Mary N. Johnston, Daniel Cohen, Todd M. Allen, Eric S. Rosenberg, Bruce D. Walker, and Marcus Altfeld. Selective Depletion of High-Avidity Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells after Early HIV-1 Infection. J. Virol., 81(8):4199-4214, Apr 2007. PubMed ID: 17287271. Show all entries for this paper.


Displaying record number 52342

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484 LAI)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*0201
Experimental methods  
Keywords HAART, ART, responses in children

Notes

References

Luzuriaga2000 Katherine Luzuriaga, Margaret McManus, Michelle Catalina, Shane Mayack, Mark Sharkey, Mario Stevenson, and John L. Sullivan. Early Therapy of Vertical Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Control of Viral Replication and Absence of Persistent HIV-1-Specific Immune Responses. J. Virol., 74(15):6984-6991, Aug 2000. PubMed ID: 10888637. Show all entries for this paper.


Displaying record number 55469

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location Pol
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Subtype B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


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