Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 57786

Download this epitope record as JSON.

HXB2 Location	Gag(267-277) p24(135-145) DNA(1588..1620)	Gag Epitope Map
Author Location	p24(135-145)
Epitope	ILGLNKIVRMY	Epitope Alignment
Epitope Name	IY-11
Species (MHC/HLA)	human(B27, B7)
Immunogen	in vitro stimulation or selection
Experimental methods	Cytotoxicity assay
Keywords	dendritic cells

Notes

• Receptor 2B4 (CD244) is a member of the SLAM family of receptors that regulate lymphocyte development and function. 2B4 can activate or inhibit immune responses, and its expression on T cells increases during the course of HIV infection. In this study, responses to 2B4+ and 2B4- T cell populations were compared using HIV negative HLA B14 and B27 donors. CD8+ T cells were stimulated with HLA B14- and B27-restricted epitopes. Secretion of IFN-γ by HIV epitopes was lower than after stimulation with influenza epitope, and expression of signaling adaptor SAP was downregulated in 2B4+ CD8+ T cells upon HIV peptide stimulation. Thus 2B4+ CD8+ T cells may contribute to poor viral control of HIV.
• Previously-documented epitope ILGLNKIVRMY was used.

References

Aldy2011 Kim N. Aldy, Nathan C. Horton, Porunelloor A. Mathew, and Stephen O. Mathew. 2B4+ CD8+ T Cells Play an Inhibitory Role against Constrained HIV Epitopes. Biochem. Biophys. Res. Commun., 405(3):503-507, 18 Feb 2011. PubMed ID: 21256826. Show all entries for this paper.

Displaying record number 52952

Download this epitope record as JSON.

HXB2 Location	Gag(267-277) p24(135-145) DNA(1588..1620)	Gag Epitope Map
Author Location	Gag(267-277)
Epitope	ILGLNKIVRMY	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B7 supertype)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords	vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Notes

• After injection of an anti-HIV-1 lipopeptide vaccine and the booster injections, a response was observed in >85% of 28 volunteers, and a long-term immune response was observed in >50% of the volunteers. A positive effect of QS21 adjuvant was found for B-and CD4+T-cell responses. A higher number of CD8+ T-cell epitopes was induced after a fourth boost injection. This epitope was one of the most frequently recognized of the 31 epitopes that the vaccinated volunteers responded to.
• A response to this peptide was induced in three patients after immunization with lipopeptides alone (no adjuvant) after the third and the fourth boost, and induced in two patients after immunization with lipopeptides and QS21 adjuvant after the third boost. Variant IyGLNKIVRMY was also recognized in two patients.

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.