Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 61844

Download this epitope record as JSON.

HXB2 Location	Pol(897-905) Integrase(182-190) DNA(4773..4799)	Pol Epitope Map
Author Location
Epitope	IHNFKRKGG	Epitope Alignment
Epitope Name	IG9
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, vaccine
Patient MHC/HLA	VID410: A*30:02, B*18:01, B*57:03, C*07:01, C*18:01; VID404: A*68:01, B*44:02, B*51:01, C*07:04, C*14:02, DQB1*06:02, DQB1*06:05, DRB1*13:01, DRB1*13:02, DRB3
Country	United Kingdom
Experimental methods	Intracellular cytokine staining, Other
Keywords	vaccine-induced immune responses, novel epitope

Notes

• Since CTL response in natural HIV-1 infections is mostly against variable but immunodominant epitopes, lymphocytes from 12 vaccine(HIVconsv)-exposed subjects of the HIV-CORE 002 study were used to determine and define 14 less variable but typically subdominant, optimal novel epitopes.
• Epitope IHNFKRKGG (IG9) is within peptide VQMAVFIHNFKRKGGI (HC164) that was recognized by VIDs 404 and 410, 2/12 vaccinated subjects. IG9 is of unknown restrtiction but is a novel epitope.

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.