HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 55328

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HXB2 Location Pol(314-322)
RT(159-167)
DNA(3024..3050)
Pol Epitope Map
Author Location RT Pol
Epitope IFQSSMTKI Epitope Alignment
IFQSSMTKI epitope logo
Show epitope variants
Epitope Name P
Subtype A, B, C
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, antagonism

Vaccine Details

Vaccine type DNA with CMV promotor, modified vaccinia Ankara (MVA), DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade, B clade, C clade Du422, other
Vaccine component Gag, Nef, RT

Notes

References

Larke2007 Natasha Larke, Eung-Jun Im, Ralf Wagner, Carolyn Williamson, Anna-Lise Williamson, Andrew J. McMichael, and Tomáš Hanke. Combined Single-Clade Candidate HIV-1 Vaccines Induce T Cell Responses Limited by Multiple Forms of In Vivo Immune Interference. Eur. J. Immunol., 37(2):566-577, Feb 2007. PubMed ID: 17230443. Show all entries for this paper.


Displaying record number 57934

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HXB2 Location Pol(314-322)
RT(159-167)
DNA(3024..3050)
Pol Epitope Map
Author Location  
Epitope IFQSSMTKI Epitope Alignment
IFQSSMTKI epitope logo
Show epitope variants
Epitope Name P
Subtype A
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Cytotoxicity assay, HLA binding, Intracellular cytokine staining
Keywords immunodominance, vaccine antigen design, optimal epitope

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA)
Vaccine strain A clade, multiple epitope immunogen
Vaccine component p17 Gag, p24 Gag, other

Notes

References

Im2011 Eung-Jun Im, Jessie P. Hong, Yaowaluck Roshorm, Anne Bridgeman, Sven Létourneau, Peter Liljeström, Mary Jane Potash, David J. Volsky, Andrew J. McMichael, and Tomáš Hanke. Protective Efficacy of Serially Up-Ranked Subdominant CD8+ T Cell Epitopes against Virus Challenges. PLoS Pathog., 7(5):e1002041, May 2011. PubMed ID: 21625575. Show all entries for this paper.


Displaying record number 58373

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HXB2 Location Pol(314-322)
RT(159-167)
DNA(3024..3050)
Pol Epitope Map
Author Location  
Epitope IFQSSMTKI Epitope Alignment
IFQSSMTKI epitope logo
Epitope Name P
Subtype A
Species (MHC/HLA) mouse(H-2Kd)
Immunogen vaccine
Experimental methods Cytotoxicity assay, Intracellular cytokine staining
Keywords mother-to-infant transmission, vaccine antigen design

Vaccine Details

Vaccine type Bacillus BCG prime with vaccinia Ankara (MVA) boost
Vaccine strain A clade, multiple epitope immunogen
Vaccine component p17 Gag, p24 Gag, other

Notes

References

Im2007 Eung-Jun Im, Narcis Saubi, Goretti Virgili, Clare Sander, Denise Teoh, Jose M. Gatell, Helen McShane, Joan Joseph, and Tomáš Hanke. Vaccine Platform for Prevention of Tuberculosis and Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1 through Breastfeeding. J. Virol., 81(17):9408-9418, Sep 2007. PubMed ID: 17596303. Show all entries for this paper.


Displaying record number 55000

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HXB2 Location Pol(314-322)
RT(159-167)
DNA(3024..3050)
Pol Epitope Map
Author Location RT( C-96BW15C05)
Epitope IFQSSMTKI Epitope Alignment
IFQSSMTKI epitope logo
Epitope Name E
Subtype C
Species (MHC/HLA) mouse(H-2d)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA, alphavirus replicon
Vaccine strain C clade C-96BW04.09, C clade C-96BW15C05
Vaccine component Gag, Gag-Pol, Pol

Notes

References

Megede2006 Jan Zur Megede, Gillis R. Otten, Barbara Doe, Hong Liu, Ranjana Srivastava, Catherine Greer, Harold Legg, Tony Tang, John M. Polo, John J. Donnelly, Jeffrey B. Ulmer, and Susan W. Barnett. Evaluation of Human Immunodeficiency Virus Type 1 Subtype C gag, pol, and gagpol DNA and Alphavirus Replicon Vaccines. Vaccine, 24(15):2755-2763, 5 Apr 2006. PubMed ID: 16460840. Show all entries for this paper.


Displaying record number 59105

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HXB2 Location Pol(314-322)
RT(159-167)
DNA(3024..3050)
Pol Epitope Map
Author Location RT(159-167)
Epitope IFQSSMTKI Epitope Alignment
IFQSSMTKI epitope logo
Subtype B
Species (MHC/HLA) human, mouse(H-2d)
Immunogen vaccine
Experimental methods CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type DNA
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol, Tat

Notes

References

Reguzova2015 Alena Reguzova, Denis Antonets, Larisa Karpenko, Alexander Ilyichev, Rinat Maksyutov, and Sergei Bazhan. Design and Evaluation of Optimized Artificial HIV-1 Poly-T Cell-Epitope Immunogens. PLoS One, 10(3):e0116412, 2015. PubMed ID: 25786238. Show all entries for this paper.


Displaying record number 57571

Download this epitope record as JSON.

HXB2 Location Pol(314-322)
RT(159-167)
DNA(3024..3050)
Pol Epitope Map
Author Location Pol
Epitope IFQSSMTKI Epitope Alignment
IFQSSMTKI epitope logo
Epitope Name P
Subtype A
Species (MHC/HLA) mouse
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Vaccine Details

Vaccine type adenovirus
Vaccine strain A clade
Vaccine component Gag, other

Notes

References

Bridgeman2009 Anne Bridgeman, Yaowaluck Roshorm, Linda J. Lockett, Zheng-Zhou Xu, Richard Hopkins, Jan Shaw, Gerald W. Both, and Tomáš Hanke. Ovine Atadenovirus, a Novel and Highly Immunogenic Vector in Prime-Boost Studies of a Candidate HIV-1 Vaccine. Vaccine, 28(2):474-483, 11 Dec 2009. PubMed ID: 19853074. Show all entries for this paper.


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