HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 22 matching records:

Displaying record number 59798

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Species (MHC/HLA) human(A*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59800

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59795

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59796

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56029

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10(p17)
Subtype B
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 54364

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name B40-IL10(p17)
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54889

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location  
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 55714

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10-B40
Subtype B, F
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Country Argentina
Experimental methods  
Keywords dynamics, HLA associated polymorphism

Notes

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.


Displaying record number 56362

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 59797

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 116

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Species (MHC/HLA) human(B*4001)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 60955

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Subtype B
Species (MHC/HLA) human(B*4001)
Immunogen HIV-1 infection
Patient MHC/HLA 51729: A*2401, A*2401, B*3505, B*4001, C*0304, C*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 59799

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Species (MHC/HLA) human(B*4201)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 115

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Wagner1998b L. Wagner, O. O. Yang, E. A. Zepeda, Y. Ge, S. A. Kalams, B. D. Walker, M. S. Pasternack, and A. D. Luster. Beta-Chemokines Are Released from HIV-1-Specific Cytolytic T Cell Granules Complexed to Proteoglycans. Nature, 391:908-911, 1998. PubMed ID: 9495345. Show all entries for this paper.


Displaying record number 1522

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17(92-101 SF2)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 1840

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17( SF2)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.


Displaying record number 52239

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords class I down-regulation by Nef

Notes

References

Yang2002 Xinzhen Yang, Juliette Lee, Erin M. Mahony, Peter D. Kwong, Richard Wyatt, and Joseph Sodroski. Highly Stable Trimers Formed by Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Fused with the Trimeric Motif of T4 Bacteriophage Fibritin. J. Virol., 76(9):4634-4642, May 2002. PubMed ID: 1932429. Show all entries for this paper.


Displaying record number 52788

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17(92-101 NL43)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Subtype B
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication, Chromium-release assay
Keywords escape

Notes

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.


Displaying record number 52852

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location Gag(92-101 B consensus)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Subtype B
Species (MHC/HLA) human(B60)
Immunogen vaccine
Experimental methods Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords dynamics, escape, mutation acquisition

Vaccine Details

Vaccine type adeno-associated virus (AAV)
Vaccine component gp120

Notes

References

Brainard2004 Diana M. Brainard, William G. Tharp, Elva Granado, Nicholas Miller, Alicja K. Trocha, Xiang-Hui Ren, Brian Conrad, Ernest F. Terwilliger, Richard Wyatt, Bruce D. Walker, and Mark C. Poznansky. Migration of Antigen-Specific T Cells away from CXCR4-Binding Human Immunodeficiency Virus Type 1 gp120. J. Virol., 78(10):5184-5193, May 2004. PubMed ID: 15113900. Show all entries for this paper.


Displaying record number 53149

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name Gag/p17-IL10
Subtype B
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords binding affinity, epitope processing, TCR usage, characterizing CD8+ T cells

Notes

References

Yang2003a Otto O. Yang, Phuong T. Nguyen Sarkis, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL. J. Immunol., 171(7):3718-3724, 1 Oct 2003. PubMed ID: 14500671. Show all entries for this paper.


Displaying record number 1809

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17(92-101)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Species (MHC/HLA) human(B*60, B*61)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 61285

HXB2 Location Gag(92-101)
p17(92-101)
DNA(1063..1092)
Gag Epitope Map
Author Location p17(92-101 NL4-3)
Epitope IEIKDTKEAL Epitope Alignment
IEIKDTKEAL epitope logo
Epitope Name IL10
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords epitope processing

Notes

References

Rucevic2016 Marijana Rucevic, Georgio Kourjian, Julie Boucau, Renata Blatnik, Wilfredo Garcia Bertran, Matthew J. Berberich, Bruce D. Walker, Angelika B. Riemer, and Sylvie Le Gall. Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses. J. Virol., 90(19):8605-8620, 1 Oct 2016. PubMed ID: 27440904. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health