HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 59794

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location Pol(357-365)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(A*34)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61635

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name B40-IL9
Subtype B
Species (MHC/HLA) human(B*40)
Immunogen HIV-1 infection
Country Canada
Experimental methods Chromium-release assay, Other
Keywords epitope processing, escape

Notes

References

Zhang2012 Shao Chong Zhang, Eric Martin, Mariko Shimada, Sasha Blue Godfrey, Jennifer Fricke, Shirley Locastro, Nicole Y. Lai, Paul Liebesny, Jonathan M. Carlson, Chanson J. Brumme, Oluwatobi Awele Ogbechie, Huabiao Chen, Bruce D. Walker, Zabrina L. Brumme, Daniel G. Kavanagh, and Sylvie Le Gall. Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals. J. Immunol., 188(12):5924-5934, 15 Jun 2012. PubMed ID: 22586036. Show all entries for this paper.


Displaying record number 62504

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location Pol(357-365)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(B*40)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay
Keywords assay or method development, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Balamurugan2018 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones. J. Virol., 92(16), 15 Aug 2018. PubMed ID: 29899094. Show all entries for this paper.


Displaying record number 55201

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location  
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 55087

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location Pol
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name IL-9
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape, TCR usage, mutation acquisition

Notes

References

Yu2007 Xu G. Yu, Mathias Lichterfeld, Katie L. Williams, Javier Martinez-Picado, and Bruce D. Walker. Random T-Cell Receptor Recruitment in Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cells from Genetically Identical Twins Infected with the Same HIV-1 Strain. J Virol, 81(22):12666-12669, Nov 2007. PubMed ID: 17804503. Show all entries for this paper.


Displaying record number 56037

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name IL9(RT)
Subtype B
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 54367

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name B40-IL9(RT)
Species (MHC/HLA) human(B40)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 1201

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT(202-210 LAI)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Subtype B
Species (MHC/HLA) human(B*40:01)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 55059

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location Pol(357-365)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Show epitope variants
Epitope Name IL9
Species (MHC/HLA) human(B*40:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*02:01, A*24:02, B*40:01, B*50:01, C*03, Cw4
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords immunodominance, escape, variant cross-reactivity

Notes

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 57323

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location Pol
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Subtype A, CRF02_AG, CRF06_cpx, CRF09_cpx
Species (MHC/HLA) human(B*60)
Immunogen HIV-1 infection
Country Burkina Faso
Experimental methods Other
Keywords drug resistance

Notes

References

Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.


Displaying record number 1811

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT(202-210)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Species (MHC/HLA) human(B*60, B*61)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 52744

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A24, B38, B60, C*12, Cw2
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, supervised treatment interruptions (STI), early treatment

Notes

References

Montefiori2003 David C. Montefiori, Marcus Altfeld, Paul K. Lee, Miroslawa Bilska, Jintao Zhou, Mary N. Johnston, Feng Gao, Bruce D. Walker, and Eric S. Rosenberg. Viremia Control Despite Escape from a Rapid and Potent Autologous Neutralizing Antibody Response after Therapy Cessation in an HIV-1-Infected Individual. J. Immunol., 170(7):3906-3914, Apr 2003. PubMed ID: 12646660. Show all entries for this paper.


Displaying record number 1841

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT( SF2)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Altfeld2000 M. A. Altfeld, A. Trocha, R. L. Eldridge, E. S. Rosenberg, M. N. Phillips, M. M. Addo, R. P. Sekaly, S. A. Kalams, S. A. Burchett, K. McIntosh, B. D. Walker, and P. J. Goulder. Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay. J. Virol., 74:8541, 2000. PubMed ID: 10954555. Show all entries for this paper.


Displaying record number 1525

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT( SF2)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Species (MHC/HLA) human(B60)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 59793

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location Pol(357-365)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name IL9
Species (MHC/HLA) human(C*03)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61296

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT(357-365 NL4-3)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name IL9
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords epitope processing

Notes

References

Rucevic2016 Marijana Rucevic, Georgio Kourjian, Julie Boucau, Renata Blatnik, Wilfredo Garcia Bertran, Matthew J. Berberich, Bruce D. Walker, Angelika B. Riemer, and Sylvie Le Gall. Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses. J. Virol., 90(19):8605-8620, 1 Oct 2016. PubMed ID: 27440904. Show all entries for this paper.


Displaying record number 58085

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location Pol
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 62840

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HXB2 Location Pol(357-365)
RT(202-210)
DNA(3153..3179)
Pol Epitope Map
Author Location RT(202-210)
Epitope IEELRQHLL Epitope Alignment
IEELRQHLL epitope logo
Epitope Name IL-9
Subtype B, C
Species (MHC/HLA) human
Immunogen HIV-1 infection, engineered
Experimental methods Other, Relative replication capacity assay
Keywords acute/early infection, HLA associated polymorphism, chronic infection, protective allele

Notes

References

Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.


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