Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 55529

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HXB2 Location	Pol(793-801) Integrase(78-86) DNA(4461..4487)	Pol Epitope Map
Author Location	Pol(792-800)
Epitope	HVASGYIEA	Epitope Alignment
Epitope Name	HA9
Subtype	B
Species (MHC/HLA)	human(B*54:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Asian-expressed HLA-B*5401-restricted epitopes were identified using overlapping-peptide methods and characterized. 5 epitopes from Pol and Nef induced CTL responses that killed target cells in more than 25% of B*5401-carrying tested patients.
• 7 peptides from Pol and Nef are listed in Fig. 2 as candidates for B*5401 restriction. No Gag-specific epitopes were identified in this study from the patient whose lymphocytes were screened.
• HVASGYIEA was defined as an optimal epitope for HLA-B*5401 restriction, using truncated peptides.

References

Kitano2008 Mitsutaka Kitano, Naoki Kobayashi, Yuka Kawashima, Tomohiro Akahoshi, Kiyoshi Nokihara, Shinichi Oka, and Masafumi Takighuchi. Identification and Characterization of HLA-B*5401-Restricted HIV-1-Nef and Pol-Specific CTL Epitopes. Microbes Infect, 10(7):7647-72, Jun 2008. PubMed ID: 18538615. Show all entries for this paper.

Displaying record number 58615

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HXB2 Location	Pol(793-801) Integrase(78-86) DNA(4461..4487)	Pol Epitope Map
Author Location	Pol(792-800)
Epitope	HVASGYIEA	Epitope Alignment
Epitope Name	HA9
Subtype	B
Species (MHC/HLA)	human(B*54:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods
Keywords	optimal epitope, A-list

Notes

• C. Brander noted this as an optimal B*5401 epitope based on data from Kitano Microbes and Infection 10 (2008).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 62848

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HXB2 Location	Pol(793-801) Integrase(78-86) DNA(4461..4487)	Pol Epitope Map
Author Location	Integrase(78-86)
Epitope	HVASGYIEA	Epitope Alignment
Epitope Name	HA9
Subtype	B, C
Species (MHC/HLA)	human
Immunogen	HIV-1 infection, engineered
Experimental methods	Other, Relative replication capacity assay
Keywords	acute/early infection, HLA associated polymorphism, chronic infection, protective allele

Notes

• The in vitro replicative capacity (RC) of recombinant subtype B NL4-3 viruses expressing subtype C RT-integrase sequences derived from recently infected patients correlated positively with log subsequent VL set point and a higher rate of CD4 decline, while the RC of NL4-3 recombinants expressing subtype C RT-integrase sequences derived from chronically infected patients correlated positively with log VL but negatively with CD4 count. Protective & risk HLA alleles were associated with lower and higher RC values, respectively, and the number of HLA-associated polymorphisms in RT correlated positively with RC while the inverse was observed for integrase. About 90% of RT-integrase polymorphisms significantly associated with altered RC occurred inside or within 5 aa of A-list epitopes (LANL HIV Database).
• Integrase polymorphism I84M and subtype C consensus I84 were associated with altered RC and are within best-defined A-list epitope HVASGYIEA, HA9, known to bind to B*54:01. Residue 84 is also located within overlapping epitope IEAEVIPAET.
• I84M occurred in 89 participant-derived recombinant viruses with a median RC of 0.91, while 363 analogous viruses with consensus I84 had a median RC of 0.93, relative to unmodified NL4-3.

References

Ojwach2018 Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, and Jaclyn K. Mann. Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection. J. Virol., 92(19), 1 Oct 2018. PubMed ID: 29997209. Show all entries for this paper.