HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 27 matching records:

Displaying record number 59787

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59783

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(B*35:02, B*35:03, B*53:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59788

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(B*55)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 62501

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(B*57)
Immunogen in vitro stimulation or selection
Experimental methods Chromium-release assay, Peptide titration
Keywords assay or method development, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Balamurugan2018 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones. J. Virol., 92(16), 15 Aug 2018. PubMed ID: 29899094. Show all entries for this paper.


Displaying record number 2011

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name Nef-HQ10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 53129

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(114-123)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.


Displaying record number 54387

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location  
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 54620

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Show epitope variants
Epitope Name HQ10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Switzerland
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, HLA associated polymorphism, elite controllers

Notes

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54798

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 54822

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name nefHQ10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 57389

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen in vitro stimulation or selection, HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development, chronic infection

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 58496

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 58770

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name Nef-HQ10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 59782

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 61570

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name B57-HQ10(nef)
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA OP246: A*01, A*02, B*51, B*57, C*06; AC-38: A*01, A*03, B*07, B*57, C*06, C*07; AC-108: A*02, B*57, B*61, C*03, C*06; AC-109: A*01, A*02, B*14, B*57, C*07, C*08
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords acute/early infection, protective allele

Notes

References

Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.


Displaying record number 62279

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125 B*57)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Show epitope variants
Epitope Name Nef-HQ10
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords escape, chronic infection, protective allele

Notes

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


Displaying record number 53544

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A3, B57, B7, Cw6, Cw7
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 54873

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location  
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 1034

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


Displaying record number 55611

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 1035

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125 BRU)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Culmann1991 B. Culmann, E. Gomard, M.-P. Kieny, B. Guy, F. Dreyfus, A.-D. Saimot, D. Sereni, D. Sicard, and J.-P. Levy. Six Epitopes with Human Cytotoxic CD8+ Cells in the Central Region of the HIV-1 Nef Protein. J. Immunol., 146:1560-1565, 1991. Nef-specific CTL were generated from six seropositive donors. Six epitopes were defined, all localized to two regions in the central part of Nef. Some epitopes could be recognized in the contexts of several HLA class I molecules. Peptides were based on BRU epitopes: QVPLRPMTYK, HLA A3, A11, B35; AAVDLSHFLKEK, HLA A11; HTQGYFPQWQ, HLA B17;TQGYFPQWQNYT, HLA B17, B37, NYTPGPGVRYPLT, HLA B7; and GVRYPLTFGWCYKLVP, HLA B18). PubMed ID: 1704397. Show all entries for this paper.


Displaying record number 1389

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HTQ
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 53657

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Subtype B, C
Species (MHC/HLA) human(B57, B63)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, HLA cross-presentation, optimal epitope, novel epitope

Notes

References

Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.


Displaying record number 59212

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Show epitope variants
Epitope Name HQ10
Subtype B
Species (MHC/HLA) human(B*57:01)
Immunogen HIV-1 infection
Patient MHC/HLA P1: B*57:01; P2: B*57:01; P3: B*57:01; P4: B*57:01; P5: B*57:01; P6: B*57:01
Country United States
Experimental methods Other
Keywords dynamics, rate of progression, elite controllers

Notes

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 59785

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(B*58:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59786

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(C*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59784

Download this epitope record as JSON.

HXB2 Location Nef(116-125)
DNA(9142..9171)
Nef Epitope Map
Author Location Nef(116-125)
Epitope HTQGYFPDWQ Epitope Alignment
HTQGYFPDWQ epitope logo
Epitope Name HQ10
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health