HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 37 matching records:

Displaying record number 59780

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(B*1503)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59779

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54393

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name B57-HW9(Nef)
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 52597

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Species (MHC/HLA) human(B57)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53830

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Show epitope variants
Subtype C
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Patient MHC/HLA A*3001, A*66, B*4201, B*5802, Cw*0602, Cw*1701; A*66, A*68, B*57, B*5802, Cw*0602, Cw*0701
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords responses in children, mother-to-infant transmission, escape, acute/early infection

Notes

References

Pillay2005 Thillagavathie Pillay, Hua-Tang Zhang, Jan W. Drijfhout, Nicola Robinson, Helen Brown, Munira Khan, Jagadesa Moodley, Miriam Adhikari, Katja Pfafferott, Margaret E. Feeney, Anne St. John, Edward C. Holmes, Hoosen M. Coovadia, Paul Klenerman, Philip J. R. Goulder, and Rodney E. Phillips. Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(18):12100-12105, Sep 2005. PubMed ID: 16140787. Show all entries for this paper.


Displaying record number 52915

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location  
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords epitope processing, assay or method development

Notes

References

Draenert2004 Rika Draenert, Christian Brander, Xu G. Yu, Marcus Altfeld, Cori L. Verrill, Margeret E. Feeney, Bruce D. Walker, and Philip J. R. Goulder. Impact of Intrapeptide Epitope Location on CD8 T Cell Recognition: Implications for Design of Overlapping Peptide Panels. AIDS, 18(6):871-876, 9 Apr 2004. PubMed ID: 15060434. Show all entries for this paper.


Displaying record number 60954

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701, B57)
Immunogen HIV-1 infection
Patient MHC/HLA 10849: A*2301, A*6801, B*3543, B*5703, Cw*0102, Cw*0210; 67200: A*0101, A*2401, B*0801, B*5701, Cw*0602, Cw*0701; 44091: A*0201, A*2401, B*4401, B*5701, Cw*0501, Cw*6002
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 53734

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124 BRU)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Show epitope variants
Subtype B, CRF02_AG
Species (MHC/HLA) human(B57, B58)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 55855

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Show epitope variants
Epitope Name HW9
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Navis2008a Marjon Navis, Ingrid M. M. Schellens, Peter van Swieten, José A. M. Borghans, Frank Miedema, Neeltje A. Kootstra, Debbie van Baarle, and Hanneke Schuitemaker. A Nonprogressive Clinical Course in HIV-Infected Individuals Expressing Human Leukocyte Antigen B57/5801 Is Associated with Preserved CD8+ T Lymphocyte Responsiveness to the HW9 Epitope in Nef. J. Infect. Dis., 197(6):871-879, 15 Mar 2008. PubMed ID: 18279072. Show all entries for this paper.


Displaying record number 53643

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Show epitope variants
Epitope Name HW9
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords responses in children, mother-to-infant transmission, escape, characterizing CD8+ T cells

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 56229

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location  
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Subtype C
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 62175

HXB2 Location Nef(116-124) Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Subtype C
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Botswana, South Africa
Experimental methods  
Keywords acute/early infection, Nef-mediated down-regulation

Notes

References

Mann2014 Jaclyn K. Mann, Denis Chopera, Saleha Omarjee, Xiaomei T. Kuang, Anh Q. Le, Gursev Anmole, Ryan Danroth, Philip Mwimanzi, Tarylee Reddy, Jonathan Carlson, Mopo Radebe, Philip J. R. Goulder, Bruce D. Walker, Salim Abdool Karim, Vladimir Novitsky, Carolyn Williamson, Mark A. Brockman, Zabrina L. Brumme, and Thumbi Ndung'u. Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure. Virology, 468-470:214-225 doi, Nov 2014. PubMed ID: 25193656 Show all entries for this paper.


Displaying record number 52600

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Species (MHC/HLA) human(B*57)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 56415

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, viral fitness and reversion, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 57046

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, CTL neutralization assay, Chromium-release assay, Other
Keywords elite controllers, neutralization by CTL

Notes

References

Chen2009a Huabiao Chen, Alicja Piechocka-Trocha, Toshiyuki Miura, Mark A. Brockman, Boris D. Julg, Brett M. Baker, Alissa C. Rothchild, Brian L. Block, Arne Schneidewind, Tomohiko Koibuchi, Florencia Pereyra, Todd M. Allen, and Bruce D. Walker. Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes. J. Virol., 83(7):3138-3149, Apr 2009. PubMed ID: 19158248. Show all entries for this paper.


Displaying record number 57253

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 57317

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART, supervised treatment interruptions (STI), early treatment, elite controllers

Notes

References

Streeck2009 Hendrik Streeck, Heiko Jessen, Claudia Kuecherer, Bin Li, Arne B. Jessen, Stephan Dupke, Axel Baumgarten, Ingrid Stahmer, Jan van Lunzen, Marcus Altfeld, Bruce D. Walker, and Todd M. Allen. Epidemiologically Linked Transmission of HIV-1 Illustrates the Impact of Host Genetics on Virological Outcome. AIDS, 23(2):259-262, 14 Jan 2009. PubMed ID: 19098497. Show all entries for this paper.


Displaying record number 57419

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location  
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Show epitope variants
Epitope Name HW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


Displaying record number 57854

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, early treatment

Notes

References

Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.


Displaying record number 59134

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.


Displaying record number 59775

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57589

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Subtype B
Species (MHC/HLA) (B*57, B*58)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.


Displaying record number 56675

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*2301, B*1402, B*5701, Cw*0701, Cw*0802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords acute/early infection

Notes

References

Goonetilleke2009 Nilu Goonetilleke, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, Gerald H. Learn, Emma L. Turnbull, Maria G Salazar, Kent J Weinhold, Stephen Moore, CHAVI Clinical Core B, Norman Letvin, Barton F. Haynes, Myron S. Cohen, Peter Hraber, Tanmoy Bhattacharya, Persephone Borrow, Alan S. Perelson, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, and Andrew J. McMichael. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med., 206(6):1253-1272, 8 Jun 2009. PubMed ID: 19487423. Show all entries for this paper.


Displaying record number 58234

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*2301, B*1402, B*5701, Cw*0701, Cw*0802
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords escape, acute/early infection, autologous responses, characterizing CD8+ T cells

Notes

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


Displaying record number 58984

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country Australia, Canada, Spain, Switzerland
Experimental methods Other
Keywords mutation acquisition

Notes

References

Bartha2013 István Bartha, Jonathan M. Carlson, Chanson J. Brumme, Paul J. McLaren, Zabrina L. Brumme, Mina John, David W. Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F. Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J. O'Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M. Allen, Viktor Müller, P. Richard Harrigan, David Heckerman, Amalio Telenti, and Jacques Fellay. A Genome-to-Genome Analysis of Associations between Human Genetic Variation, HIV-1 Sequence Diversity, and Viral Control. eLife, 2:e01123, 2013. PubMed ID: 24171102. Show all entries for this paper.


Displaying record number 59168

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name nef 116-124
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, HLA binding, Intracellular cytokine staining, Other
Keywords binding affinity, elite controllers

Notes

References

Lecuroux2014 Camille Lécuroux, Asier Sáez-Cirión, Isabelle Girault, Pierre Versmisse, Faroudy Boufassa, Véronique Avettand-Fenoël, Christine Rouzioux, Laurence Meyer, Gianfranco Pancino, Olivier Lambotte, Martine Sinet, and Alain Venet. Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8+ T Cell Response in HIV Controllers. J. Virol., 88(1):176-187, Jan 2014. PubMed ID: 24131719. Show all entries for this paper.


Displaying record number 57858

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location  
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, early treatment

Notes

References

Cellerai2011 Cristina Cellerai, Alexandre Harari, Hans Stauss, Sabine Yerly, Anna-Maria Geretti, Anne Carroll, Thynn Yee, Jonathan Ainsworth, Ian Williams, John Sweeney, Andrew Freedman, Margaret Johnson, Giuseppe Pantaleo, and Sabine Kinloch-de Loes. Early and Prolonged Antiretroviral Therapy Is Associated with an HIV-1-Specific T-Cell Profile Comparable to That of Long-Term Non-Progressors. PLoS One, 6(4):e18164, 2011. PubMed ID: 21483676. Show all entries for this paper.


Displaying record number 58632

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location  
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Species (MHC/HLA) (B*5703, B*5801)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59409

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Subtype B
Species (MHC/HLA) human(B*58)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 59776

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59777

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(C*07)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59778

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59781

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Epitope Name HW9
Species (MHC/HLA) human(C*15)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58748

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef( NL4-3)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Show epitope variants
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 61063

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef(116-124)
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CH058: A*0101, A*2301, B*1402, B*57, Cw*0701, Cw*0802
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords computational epitope prediction, escape, acute/early infection, mutation acquisition

Notes

References

Barton2016 John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, and Arup K. Chakraborty. Relative Rate and Location of Intra-Host HIV Evolution to Evade Cellular Immunity Are Predictable. Nat. Commun., 7:11660, 23 May 2016. PubMed ID: 27212475. Show all entries for this paper.


Displaying record number 56971

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 58060

HXB2 Location Nef(116-124)
DNA(9142..9168)
Nef Epitope Map
Author Location Nef
Epitope HTQGYFPDW Epitope Alignment
HTQGYFPDW epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*0101, A*2402, B*3503, B*5701, Cw*0401, Cw*0602
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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