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Displaying record number 53878

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HXB2 Location	Vif(73-81) DNA(5257..5283)	Vif Epitope Map
Author Location	Vif(73-81)
Epitope	HTGERDWHL	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B*35)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*03, A*24, B*35, B*40
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection, variant cross-reactivity, superinfection

Notes

• An individual infected with a drug-resistant strain of HIV-1 subtype B with controlled viremia became superinfected with another subtype B strain. The second strain outgrew the first despite lower replication capacity and the same viral phenotype. The strains showed differences in their epitope sequences. The CTL responses to the first strain declined after superinfection, followed by some adaptation of targeting to the new epitopes of the second strain. Differences in the recognized epitopes were suggested to have contributed to the poor immune containment of the second strain.
• The response to this epitope, HTGERDWHL, was present before superinfection but waned afterward. The epitope from the first strain had the substitution hPgerdwhl, while the second strain matched the test peptide.

References

Yang2005 Otto O. Yang, Eric S. Daar, Beth D. Jamieson, Arumugam Balamurugan, Davey M. Smith, Jacqueline A. Pitt, Christos J. Petropoulos, Douglas D. Richman, Susan J. Little, and Andrew J. Leigh Brown. Human Immunodeficiency Virus Type 1 Clade B Superinfection: Evidence for Differential Immune Containment of Distinct Clade B Strains. J. Virol., 79(2):860-868, Jan 2005. PubMed ID: 15613314. Show all entries for this paper.