Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 62468

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HXB2 Location	gp160(769-777) gp41(258-266) DNA(8529..8555)	gp160 Epitope Map
Author Location	Env
Epitope	`HRLRDLLLI`	Epitope Alignment
Epitope Name	HI9
Subtype	B
Species (MHC/HLA)	human(B*27:02)
Immunogen	HIV-1 infection
Country	United Kingdom
Experimental methods	Other, Tetramer binding
Keywords	immunodominance, chronic infection, protective allele

Notes

HLA-B*27:02 is associated with slower disease progression and lower viral loads to a similar or greater degree than protective HLA-B*27:05 which has a 10-fold higher prevalence in some HIV cohorts. These similar protective effects are mediated by differential epitope binding preferences resulting in distinct immunodominant hierarchies of CTL responses for B*27:02 and B*27:05. An optimal immunodominant B*27:02-restricted Nef VW9-specific response was defined.
About 57% of 7 B*27:02+ subjects responded to epitope HRLRDLLLI as compared to 0% of 19 B*27:05+ subjects.

References

Adland2018 Emily Adland, Matilda Hill, Nora Lavandier, Anna Csala, Anne Edwards, Fabian Chen, Marek Radkowski, Justyna D. Kowalska, Dimitrios Paraskevis, Angelos Hatzakis, Humberto Valenzuela-Ponce, Katja Pfafferott, Ian Williams, Pierre Pellegrino, Persephone Borrow, Masahiko Mori, Jürgen Rockstroh, Julia G. Prado, Beatriz Mothe, Judith Dalmau, Javier Martinez-Picado, Gareth Tudor-Williams, John Frater, Anette Stryhn, Soren Buus, Gustavo Reyes Teran, Simon Mallal, Mina John, Susan Buchbinder, Gregory Kirk, Jeffrey Martin, Nelson Michael, Jacques Fellay, Steve Deeks, Bruce Walker, Santiago Avila-Rios, David Cole, Christian Brander, Mary Carrington, and Philip Goulder. Differential Immunodominance Hierarchy of CD8+ T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection. J. Virol., 92(4), 15 Feb 2018. PubMed ID: 29167337. Show all entries for this paper.

Displaying record number 62481

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HXB2 Location	gp160(769-777) gp41(258-266) DNA(8529..8555)	gp160 Epitope Map
Author Location	Env
Epitope	`HRLRDLLLI`	Epitope Alignment
Epitope Name	HI9
Subtype	B
Species (MHC/HLA)	human(B*27:05)
Immunogen	HIV-1 infection
Country	United Kingdom
Experimental methods	Other, Tetramer binding
Keywords	immunodominance, chronic infection, protective allele

Notes

HLA-B*27:02 is associated with slower disease progression and lower viral loads to a similar or greater degree than protective HLA-B*27:05 which has a 10-fold higher prevalence in some HIV cohorts. These similar protective effects are mediated by differential epitope binding preferences resulting in distinct immunodominant hierarchies of CTL responses for B*27:02 and B*27:05. An optimal immunodominant B*27:02-restricted Nef VW9-specific response was defined.
None of the 19 B*27:05+ subjects responded to Env HI9 (HRLRDLLLI) as compared to about 57% of 7 B*27:02+ subjects. Despite strong peptide-MHC binding of Env HI9 to B*27:05, it lacks immunogenicity.

References

Displaying record number 862

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HXB2 Location	gp160(769-777) gp41(258-266) DNA(8529..8555)	gp160 Epitope Map
Author Location	gp41(769-777 BH10)
Epitope	`HRLRDLLLI`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

Recognized by CTL derived from acute seroconverter.

References

Safrit1994a J. T. Safrit, C. A. Andrews, T. Zhu, D. D. Ho, and R. A. Koup. Characterization of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocyte Clones Isolated during Acute Seroconversion: Recognition of Autologous Virus Sequences within a Conserved Immunodominant Epitope. J. Exp. Med., 179:463-472, 1994. HIV-1 specific CTL clones were isolated from two individuals at acute seroconversion. In one patient, two HLA A31-restricted clones recognized the same fragment of gp41, peptide RLRDLLLIVTR, but one was sensitive to a Thr to Val substitution, while the other was not. A CTL HLA A32-restricted clone from the other patient recognized the gp41 peptide VLSIVNRVRQGYSPLSFQTH. Autologous viral sequences from seroconversion were recognized by the CTL clones, but not the HIV-1 strain MN. PubMed ID: 8294860. Show all entries for this paper.