HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 12 matching records:

Displaying record number 59774

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HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location Gag(144-152)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Epitope Name HL9
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56370

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HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location p24(144-152)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Epitope Name HL9
Subtype B
Species (MHC/HLA) human(B*15)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 62107

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HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location p24(144-152 NL4-3)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Species (MHC/HLA) human(B*15)
Immunogen computer prediction
Experimental methods Other, Relative replication capacity assay
Keywords vaccine antigen design, viral fitness and reversion

Notes

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 59188

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HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location p24(12-20 NL4.3)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Subtype B
Species (MHC/HLA) human(B*15)
Immunogen HIV-1 infection
Experimental methods In vitro proteasome digestion, Other
Keywords epitope processing

Notes

References

Kourjian2014 Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain, and Sylvie Le Gall. Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. J. Immunol., 192(8):3496-3506, 15 Apr 2014. PubMed ID: 24616479. Show all entries for this paper.


Displaying record number 60620

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HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location p24(12-20)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Epitope Name HL-9
Subtype B, C
Species (MHC/HLA) human(B*15:10)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tenzer2014 Stefan Tenzer, Hayley Crawford, Phillip Pymm, Robert Gifford, Vattipally B. Sreenu, Mirjana Weimershaus, Tulio de Oliveira, Anne Burgevin, Jan Gerstoft, Nadja Akkad, Daniel Lunn, Lars Fugger, John Bell, Hansjörg Schild, Peter van Endert, and Astrid K. N. Iversen. HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification. Cell Rep., 7(2):448-463, 24 Apr 2014. PubMed ID: 24726370. Show all entries for this paper.


Displaying record number 54126

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HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location  
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Species (MHC/HLA) human(B*15:10)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 59771

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HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location Gag(144-152)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Epitope Name HL9
Species (MHC/HLA) human(B*39)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59773

Download this epitope record as JSON.

HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location Gag(144-152)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Epitope Name HL9
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59772

Download this epitope record as JSON.

HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location Gag(144-152)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Epitope Name HL9
Species (MHC/HLA) human(C*06)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 135

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HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location Gag(146-154)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Species (MHC/HLA) chimpanzee(Patr-B*02)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Balla1999b S. S. Balla-Jhagjhoorsingh, G. Koopman, P. Mooij, T. G. Haaksma, V. J. Teeuwsen, R. E. Bontrop, and J. L. Heeney. Conserved CTL epitopes shared between HIV-infected human long-term survivors and chimpanzees. J. Immunol., 162:2308-14, 1999. PubMed ID: 9973508. Show all entries for this paper.


Displaying record number 58021

Download this epitope record as JSON.

HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location Gag
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA A*02:01, A*24:02, B*14:02, B*39:01, C*08:02, C*12:03; A*02:01, A*03:01, B*07:02, B*39:01, C*07:02, C*12:03
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


Displaying record number 62784

Download this epitope record as JSON.

HXB2 Location Gag(144-152)
p24(12-20)
DNA(1219..1245)
Gag Epitope Map
Author Location p24(144-152)
Epitope HQAISPRTL Epitope Alignment
HQAISPRTL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen engineered
Experimental methods Other, Relative replication capacity assay
Keywords assay or method development, protective allele

Notes

References

Du2017 Yushen Du, Tian-Hao Zhang, Lei Dai, Xiaojuan Zheng, Aleksandr M. Gorin, John Oishi, Ting-Ting Wu, Janice M. Yoshizawa, Xinmin Li, Otto O. Yang, Otoniel Martinez-Maza, Roger Detels, and Ren Sun. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio, 8(6), 28 Nov 2017. PubMed ID: 29184023. Show all entries for this paper.


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