HIV molecular immunology database
Found 17 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | RT(175-183) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | Canada | |
Experimental methods | Other | |
Keywords | characterizing CD8+ T cells, elite controllers |
Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Epitope Name | Pol-HY9; RT-HY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | HAART, ART |
Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | RT Pol(330-338) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B*35) | |
Immunogen | HIV-1 infection | |
Country | Spain | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Proliferation | |
Keywords | HAART, ART, supervised treatment interruptions (STI) |
Plana2004 Montserrat Plana, Felipe Garcia, Annette Oxenius, Gabriel M. Ortiz, Anna Lopez, Anna Cruceta, Gabriel Mestre, Emilio Fumero, Catherine Fagard, Maria Antonia Sambeat, Ferran Segura, José M. Miró, Mireia Arnedo, L. Lopalcos, Tomas Pumarola, Bernard Hirschel, Rodney E. Phillips, Douglas F. Nixon, Teresa Gallart, and Jose M. Gatell. Relevance of HIV-1-Specific CD4+ Helper T-Cell Responses During Structured Treatment Interruptions in Patients With CD4+ T-Cell Nadir Above 400/mm3. J. Acquir. Immune Defic. Syndr., 36(3):791-799, 1 Jul 2004. PubMed ID: 15213562. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | ||
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.
Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | ||
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | acute/early infection |
Wilson2000 J. D. Wilson, G. S. Ogg, R. L. Allen, C. Davis, S. Shaunak, J. Downie, W. Dyer, C. Workman, S. Sullivan, A. J. McMichael, and S. L. Rowland-Jones. Direct Visualization of HIV-1-Specific Cytotoxic T Lymphocytes During Primary Infection. AIDS, 14:225-233, 2000. PubMed ID: 10716497. Show all entries for this paper.
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HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | Pol( subtype A) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Subtype | A | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS) |
Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(342-350) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Show epitope variants | ||
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 exposed seronegative, HIV-1 infection | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), immunodominance |
Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Subtype | A | |
Species (MHC/HLA) | human, macaque(B35) | |
Immunogen | HIV-1 infection, vaccine | |
Experimental methods | ||
Keywords | subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance |
Vaccine type | DNA prime with modified vaccinia Ankara (MVA) boost |
---|---|
Vaccine strain | A clade |
Vaccine component | p17 Gag, p24 Gag |
Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.
Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(342-350) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B | |
Keywords | Th1, characterizing CD8+ T cells |
Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | RT(342-350 LAI) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | review |
McMichael1994 A. J. McMichael and B. D. Walker. Cytotoxic T Lymphocytes Epitopes: Implications for HIV Vaccine. AIDS, 8S:S155-S173, 1994. Comprehensive review summarizing CTL epitopes that have known HLA type and are fine mapped to indicate epitope boundaries. Anchor residues are indicated when known for different HLA restricted epitopes. Includes a summary of the published literature, as well as much work that was in press or submitted for publication. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | RT(329-337) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 or HIV-2 infection | |
Country | Gambia | |
Experimental methods | ||
Keywords | HIV exposed persistently seronegative (HEPS), HIV-2 |
RowlandJones1995 S. L. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, A. McMichael, and H. Whittle. HIV-Specific Cytotoxic T Cells in HIV-Exposed but Uninfected Gambian Women. Nat. Med., 1:59-64, 1995. Four HIV-1 and -2 cross-reactive epitopes that are presented to CTL from HIV-infected Gambians by HLA-35 were identified. These peptides could elicit HIV-specific CTLs from 3 of 6 repeatedly exposed but seronegative sex workers who carry the HLA-B35 allele. Most CTL derived from HIV-2 positive donors also recognized the HIV-2 peptide and the analogous HIV-1 peptide. PubMed ID: 7584954. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | RT(329-337) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Species (MHC/HLA) | human(B35) | |
Immunogen | in vitro stimulation or selection | |
Experimental methods | ||
Keywords |
Lalvani1997 A. Lalvani, T. Dong, G. Ogg, A. A. Patham, H. Newell, A. V. Hill, A. J. McMichael, and S. Rowland-Jones. Optimization of a Peptide-Based Protocol Employing IL-7 for In Vitro Restimulation of Human Cytotoxic T Lymphocyte Precursors. J. Immunol. Methods, 210:65-77, 1997. PubMed ID: 9502585. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Epitope Name | B35-HY9(RT) | |
Species (MHC/HLA) | human(B35) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, immunodominance, early-expressed proteins |
Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | RT(342-350 LAI) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords | optimal epitope, A-list |
Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(330-338) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Epitope Name | HY9 | |
Subtype | B | |
Species (MHC/HLA) | human(B*35:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 8183A: A*02:01, A*03:01, B*35:01, B*51, C*04, C*06 | |
Country | United States | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining | |
Keywords | dynamics, acute/early infection |
Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(330-338) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Epitope Name | HY9 | |
Species (MHC/HLA) | human(B*35:02, B*35:03, B*53:01) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(330-338) RT(175-183) DNA(3072..3098) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(330-338) | |
Epitope |
HPDIVIYQY
|
Epitope Alignment
|
Epitope Name | HY9 | |
Species (MHC/HLA) | human(C*12) | |
Immunogen | HIV-1 infection | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay | |
Keywords | rate of progression, optimal epitope, chronic infection |
Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.