Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 61587

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HXB2 Location	Vif(63-70) DNA(5227..5250)	Vif Epitope Map
Author Location	Vif(66-73)
Epitope	HLEVQGYW	Epitope Alignment
Species (MHC/HLA)	macaque(Mamu B*17)
Immunogen	vaccine
Experimental methods	Other
Keywords	review, rate of progression, vaccine-induced immune responses, vaccine antigen design, SIV, protective allele

Notes

• This review refocuses attention on host protective HLA/ MHC class I molecules after the failure of the 2007 Merck & Co. Inc. as well as the impending 2008 Vaccine Research Center (VRC) vaccines.
• Macaque Mamu B*17-restricted Vif epitope HLEVQGYW is associated with slow progression and low viral set point([Friedrich et al. JVI 81: 3465-3476 (2007)]; [Mannes et al. J Exp Med 204:2505-2512(2007)]; [Yant et al. JVI 80:5074-5077 (2006)]; [O'Connor et. al. JVI 77:9029-9040 (2003)]).

References

Goulder2008 Philip J. R. Goulder and David I. Watkins. Impact of MHC Class I Diversity on Immune Control of Immunodeficiency Virus Replication. Nat. Rev. Immunol., 8(8):619-630, Aug 2008. PubMed ID: 18617886. Show all entries for this paper.

Displaying record number 61599

Download this epitope record as JSON.

HXB2 Location	Vif(63-70) DNA(5227..5250)	Vif Epitope Map
Author Location	Vif(66-73)
Epitope	HLEVQGYW	Epitope Alignment
Species (MHC/HLA)	macaque(Mamu B*17)
Immunogen	SIV infection
Experimental methods
Keywords	review, SIV

Notes

• The authors review the interaction between HLA-B alleles and epitopes that are able to control viral evolution.
• SIV Vif epitope HLEVQGYW is Mamu B*17-restricted [Mothe et al. JI 169(1):210-219 (2002)].

References

Goulder2012 Philip J. R. Goulder and Bruce D. Walker. HIV and HLA Class I: An Evolving Relationship. Immunity, 37(3):426-440, 21 Sep 2012. PubMed ID: 22999948. Show all entries for this paper.