Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 54829

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HXB2 Location	Gag(352-361) p24(220-229) DNA(1843..1872)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	GVGGPGHKAR	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

• CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Gong2006 Xiaoyan Gong, Xien Gui, Yuxia Zhang, and Po Tien. Screening for CD8 Cytotoxic T Lymphocytes Specific for Gag of Human Immunodeficiency Virus Type 1 Subtype B' Henan Isolate from China and Identification of Novel Epitopes Restricted by the HLA-A2 and HLA-A11 Alleles. J. Gen. Virol., 87(Pt 1):151-158, Jan 2006. PubMed ID: 16361427. Show all entries for this paper.

Displaying record number 55705

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HXB2 Location	Gag(352-361) p24(220-229) DNA(1843..1872)	Gag Epitope Map
Author Location	Gag
Epitope	GVGGPGHKAR	Epitope Alignment
Subtype	B, F
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

• Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
• Epitope GVGGPGHKAR with anchor residues at GVGGPGHKA(R) mutates to GVGGPsHKAR which is moderately supported as escape by phylogenetic correction.

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.