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Displaying record number 562

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HXB2 Location	Pol(591-600) RT(436-445) DNA(3855..3884)	Pol Epitope Map
Author Location	Pol(591-600 IIIB)
Epitope	GVETFYVDGA	Epitope Alignment
Species (MHC/HLA)	human(B45)
Immunogen	HIV-1 infection
Experimental methods
Keywords	responses in children, mother-to-infant transmission, escape

Notes

• This study describes maternal CTL responses in the context of mother-to-infant transmission.
• Detection of CTL escape mutants in the mother was associated with transmission, but the CTL-susceptible forms of the virus tended to be found in infected infants.
• No variants of this epitope were found in a non-transmitting mother who had a CTL response to it.
• This epitope spans the Pol p66 RT -- p15 (RNAse) domain.

References

Wilson1999a C. C. Wilson, R. C. Brown, B. T. Korber, B. M. Wilkes, D. J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I. C. Hanson, S. M. Widmayer, A. Wiznia, S. Clapp, A. J. Ammann, R. A. Koup, S. M. Wolinsky, and B. D. Walker. Frequent Detection of Escape from Cytotoxic T-Lymphocyte Recognition in Perinatal Human Immunodeficiency Virus (HIV) Type 1 Transmission: The Ariel Project for the Prevention of Transmission of HIV from Mother to Infant. J. Virol., 73:3975-3985, 1999. PubMed ID: 10196293. Show all entries for this paper.