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Displaying record number 57170

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	gp41(275-284)
Epitope	GRRGWEVLKY	Epitope Alignment
Epitope Name	GY10
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Patient MHC/HLA	A26, A32, B27, Cw1, Cw2
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	HIV exposed persistently seronegative (HEPS), acute/early infection

Notes

• CTL responses were measured in a highly exposed patient who was seronegative for 2 years, both before and after seroconversion. CTL responses after seroconversion were stronger, and more of the responses were associated with protective HLA allele B27.
• GRRGWEVLKY was part of a pool that was not recognized by the HEPS patient before seroconversion; it elicited a strong EliSpot response after seroconversion. The patient's consensus sequence at day 24 after seroconversion was GRRGWEiLKi.

References

Liu2009b Yi Liu, Amanda Woodward, Haiying Zhu, Thomas Andrus, John McNevin, Jean Lee, James I. Mullins, Lawrence Corey, M. Juliana McElrath, and Tuofu Zhu. Preinfection Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T Lymphocytes Failed to Prevent HIV Type 1 Infection from Strains Genetically Unrelated to Viruses in Long-Term Exposed Partners. J. Virol., 83(20):10821-10829, Oct 2009. PubMed ID: 19706711. Show all entries for this paper.