Search CTL/CD8+ T-Cell Epitope Database

Found 11 matching records:

Displaying record number 59745

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	Env(786-795)
Epitope	`GRRGWEALKY`	Epitope Alignment
Epitope Name	GY10
Species (MHC/HLA)	human(A*80)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
GRRGWEALKY had a significantly positive association with HLA A*80; it was recognized by 1/1 A*80-positive subjects and 5/252 A*80-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 59746

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	Env(786-795)
Epitope	`GRRGWEALKY`	Epitope Alignment
Epitope Name	GY10
Species (MHC/HLA)	human(B*08)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
GRRGWEALKY had a significantly positive association with HLA B*08; it was recognized by 2/21 B*08-positive subjects and 2/230 B*08-negative subjects.

References

Displaying record number 59744

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	Env(786-795)
Epitope	`GRRGWEALKY`	Epitope Alignment
Epitope Name	GY10
Species (MHC/HLA)	human(B*15:40)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
GRRGWEALKY had a significantly positive association with HLA B*1540; it was recognized by 1/1 B*1540-positive subjects and 4/251 B*1540-negative subjects.

References

Displaying record number 59741

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	Env(786-795)
Epitope	`GRRGWEALKY`	Epitope Alignment
Epitope Name	GY10
Species (MHC/HLA)	human(B*27)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
GRRGWEALKY had a significantly positive association with HLA B*27; it was recognized by 15/38 B*27-positive subjects and 16/303 B*27-negative subjects.

References

Displaying record number 1804

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	gp41(786-795)
Epitope	`GRRGWEALKY`	Epitope Alignment
Species (MHC/HLA)	human(B*27)
Immunogen	HIV-1 infection
Experimental methods
Keywords	rate of progression, acute/early infection

Notes

The CTL response to optimally defined CTL epitopes restricted by HLA class I A and B alleles in individuals who coexpressed HLA A*02, A*03, and B*07 was studied in eight HIV-1-infected subjects, two with acute infection, five with chronic, and one long-term non-progressor (LTNP).
2 to 17 epitopes were recognized in a given individual, A*02 restricted CTL response tended to be narrow and never dominated the response. 25/27 epitopes were targeted by at least one person.
GRRGWEALKY was one of the B*27-restricted epitopes tested for responses in this investigation.

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.

Displaying record number 57823

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	gp41(786-795)
Epitope	`GRRGWEALKY`	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B*27)
Immunogen	HIV-1 infection
Country	Australia
Experimental methods	CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords	rate of progression, escape, TCR usage

Notes

CTL responses were examined in 19 B*27-positive long-term non-progressors. CTL escape at R264 in the immunodominant KK10 epitope was a major determinant of viral load. Escape mutants at other B*27-restricted epitopes were uncommon. Coreceptor polymorphisms and breadth of TCR repertoire responding to KK10 were not different between patients with versus without escape at KK10.
15/18 chronically infected B*27-positive patients had wild-type sequence for subdominant epitope GRRGWEALKY. 3/18 carried possible escape mutants GqRGWEALKY or GhRGWEALKY.

References

Ammaranond2011 Palanee Ammaranond, David J. van Bockel, Kathy Petoumenos, Marylin McMurchie, Robert Finlayson, Melanie G. Middleton, Miles P. Davenport, Vanessa Venturi, Kazuo Suzuki, Linda Gelgor, John M. Kaldor, David A. Cooper, and Anthony D. Kelleher. HIV Immune Escape at an Immunodominant Epitope in HLA-B*27-Positive Individuals Predicts Viral Load Outcome. J. Immunol., 186(1):479-488, 1 Jan 2011. PubMed ID: 21115730. Show all entries for this paper.

Displaying record number 870

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	gp41(791-800 LAI)
Epitope	`GRRGWEALKY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

Optimal peptide mapped by titration J. Lieberman, pers. comm.

References

LiebermanPerCom J. Lieberman. Personal communication, 1998. Show all entries for this paper.

Displaying record number 55038

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location
Epitope	`GRRGWEALKY`	Epitope Alignment
Species (MHC/HLA)	human(B*27:05)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, optimal epitope

Notes

CTL responses were tested for both HIV-1 and EBV derived epitopes restricted by HLA-A, -B and -C alleles. HLA-B alleles more frequently induce detectable responses and that the responses are generally of greater magnitude than those for HLA-A and -C alleles.
The magnitude and frequency of CTL recognition were related to each other and that TCR avidity for HLA/peptide complexes is a more important determinant for magnitude of response than peptide binding affinity to HLA.
EBV response patterns were not significantly altered by HIV coinfection.
Epitope GRRGWEALKY elicited a magnitude of response of 215 SFC with a functional avidity of 5nM.

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.

Displaying record number 871

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	gp41(791-800 LAI)
Epitope	`GRRGWEALKY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*27:05)
Immunogen	HIV-1 infection
Experimental methods
Keywords	optimal epitope, A-list

Notes

C. Brander notes this is a B*2705 epitope.

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 59743

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	Env(786-795)
Epitope	`GRRGWEALKY`	Epitope Alignment
Epitope Name	GY10
Species (MHC/HLA)	human(B35:02, B35:03, B*53:01)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
GRRGWEALKY had a significantly positive association with HLA B*3502,B*3503,B*5301; it was recognized by 6/35 B*3502,B*3503,B*5301-positive subjects and 10/268 B*3502,B*3503,B*5301-negative subjects.

References

Displaying record number 59742

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HXB2 Location	gp160(786-795) gp41(275-284) DNA(8580..8609)	gp160 Epitope Map
Author Location	Env(786-795)
Epitope	`GRRGWEALKY`	Epitope Alignment
Epitope Name	GY10
Species (MHC/HLA)	human(C*14)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope, chronic infection

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
GRRGWEALKY had a significantly positive association with HLA C*14; it was recognized by 4/15 C*14-positive subjects and 6/253 C*14-negative subjects.