Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 771

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HXB2 Location	gp160(314-322) gp120(314-322) DNA(7164..7190)	gp160 Epitope Map
Author Location	gp120(314-322)
Epitope	GRAFVTIGK	Epitope Alignment
Species (MHC/HLA)	human(B27)
Immunogen	peptide-HLA interaction
Experimental methods
Keywords

Notes

• Study of peptide binding to HLA-B27.

References

Jardetzky1991 T. S. Jardetzky, W. S. Lane, R. A. Robinson, D. R. Madden, and D. C. Wiley. Identification of Self Peptides Bound to Purified HLA-B27. Nature, 353:326-329, 1991. A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified peptides provides information on the binding specificity of the HLA-B27 molecule. The peptides all seem to be nonamers, seven of which match to protein sequences in a database search. These self peptides derive from abundant cytosolic or nuclear proteins, such as histone, ribosomal proteins, and members of the 90K heat-shock protein family. PubMed ID: 1922338. Show all entries for this paper.

Displaying record number 53014

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HXB2 Location	gp160(314-322) gp120(314-322) DNA(7164..7190)	gp160 Epitope Map
Author Location	gp120(312-320)
Epitope	GRAFVTIGK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*27:05)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

• Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
• One of seven patients responded to this peptide with GzB producing cells and with IFN-gamma producing cells.

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.