Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 61223

HXB2 Location	Gag(140-147) p24(8-15) DNA(1207..1230)	Gag Epitope Map
Author Location	p24(140-147)
Epitope	GQMVHQAI	Epitope Alignment
		Show epitope variants
Epitope Name	GI8
Subtype	B
Species (MHC/HLA)	human(B*1302)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Relative replication capacity assay
Keywords	escape, novel epitope

Notes

• Protective HLA-B*13 was studied by following the 10 most common polymorphisms associated with it. Conserved Gag and Nef B*13-restricted epitopes were shown to have fitness costs when mutated and this makes B*13 a highly protective HLA. In addition, escape-substitutions E24Q and Q107R together, but not separately, impair the ability of Nef to downregulate the MHCI molecule. A novel B*13-restricted Gag p24 epitope GQMVHQAI was identified. Also, Gag-K436R is a compensatory mutation to escape GagI437L.
• Novel epitope GI8, GQMVHQAI, terminates at Gag 147, the most frequent B*13-associated escape substitution.

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.

Displaying record number 61751

HXB2 Location	Gag(140-147) p24(8-15) DNA(1207..1230)	Gag Epitope Map
Author Location	p24(8-15)
Epitope	GQMVHQAI	Epitope Alignment
Epitope Name	GI8
Species (MHC/HLA)	human(B*1302)
Immunogen
Experimental methods
Keywords	optimal epitope

Notes

• C. Brander notes this as a B*1302-restricted Gag p24 epitope (Murakoshi2016).

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 58174

HXB2 Location	Gag(140-147) p24(8-15) DNA(1207..1230)	Gag Epitope Map
Author Location	Gag(140-147)
Epitope	GQMVHQAI	Epitope Alignment
		Show epitope variants
Epitope Name	GI8
Species (MHC/HLA)	human(B*4801)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Intracellular cytokine staining
Keywords	variant cross-reactivity, optimal epitope

Notes

• In this study, a previously suggested epitope LI10 (Gag 138-147), LQGQMVHQAI, was experimentally shown to actually be the optimal epitope GQMVHQAI (GI8) with anchor residues glutamine at positions 2 and 4, restricted by the common Japanese HLA-B*4801. Reference: Kawashima2009.
• Variant epitope A146P, GQMVHQpI, was shown to be an escape.
• Epitope GI8 overlaps well known epitope Gag 147-155 ISPRTLNAW, ISW9 that is restricted by HLA-B*57.

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.

Naruto2011 Takuya Naruto, Hayato Murakoshi, Takayuki Chikata, Madoka Koyanagi, Yuka Kawashima, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Selection of HLA-B57-Associated Gag A146P Mutant by HLA-B*48:01-Restricted Gag140-147-Specific CTLs in Chronically HIV-1-Infected Japanese. Microbes Infect., 13(8-9):766-770, Aug 2011. PubMed ID: 21473930. Show all entries for this paper.