HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 59735

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HXB2 Location Pol(488-496)
RT(333-341)
DNA(3546..3572)
Pol Epitope Map
Author Location Pol(488-496)
Epitope GQGQWTYQI Epitope Alignment
GQGQWTYQI epitope logo
Epitope Name GI9
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope, chronic infection

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54587

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HXB2 Location Pol(488-496)
RT(333-341)
DNA(3546..3572)
Pol Epitope Map
Author Location Pol(488-496)
Epitope GQGQWTYQI Epitope Alignment
GQGQWTYQI epitope logo
Subtype B
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Patient MHC/HLA A*03:01, A*30:01, B*13:01, B*14:02, C*06:02, C*08:02
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords epitope processing, escape, mutation acquisition, viral fitness and reversion, HLA associated polymorphism

Notes

References

Honeyborne2007 Isobella Honeyborne, Andrew Prendergast, Florencia Pereyra, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Shabashini Reddy, Karen Bishop, Eshia Moodley, Kriebashnie Nair, Mary van der Stok, Noel McCarthy, Christine M. Rousseau, Marylyn Addo, James I. Mullins, Christian Brander, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes. J. Virol., 81(7):3667-3672, Apr 2007. PubMed ID: 17251285. Show all entries for this paper.


Displaying record number 54094

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HXB2 Location Pol(488-496)
RT(333-341)
DNA(3546..3572)
Pol Epitope Map
Author Location  
Epitope GQGQWTYQI Epitope Alignment
GQGQWTYQI epitope logo
Epitope Name GI9
Species (MHC/HLA) human(B*13)
Immunogen  
Experimental methods  
Keywords optimal epitope, A-list

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 62543

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HXB2 Location Pol(488-496)
RT(333-341)
DNA(3546..3572)
Pol Epitope Map
Author Location Pol(488-496)
Epitope GQGQWTYQI Epitope Alignment
GQGQWTYQI epitope logo
Epitope Name GI9
Subtype B
Species (MHC/HLA) human(B*13)
Immunogen HIV-1 infection
Patient MHC/HLA S00024: A*02, B*13, B*15, C*06, C*07; S00039: A*31, A*32, B*13, B*35, C*04, C*06
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords dynamics, chronic infection

Notes

References

Balamurugan2017 Arumugam Balamurugan, Deon Claiborne, Hwee L. Ng, and Otto O. Yang. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J. Virol., 91(16), 15 Aug 2017. PubMed ID: 28592539. Show all entries for this paper.


Displaying record number 55990

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HXB2 Location Pol(488-496)
RT(333-341)
DNA(3546..3572)
Pol Epitope Map
Author Location RT
Epitope GQGQWTYQI Epitope Alignment
GQGQWTYQI epitope logo
Epitope Name GI9(RT)
Subtype B
Species (MHC/HLA) human(B13)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 61227

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HXB2 Location Pol(488-496)
RT(333-341)
DNA(3546..3572)
Pol Epitope Map
Author Location RT(333-341)
Epitope GQGQWTYQI Epitope Alignment
GQGQWTYQI epitope logo
Show epitope variants
Epitope Name GI9
Subtype B
Species (MHC/HLA) human(B*13:02)
Immunogen HIV-1 infection
Experimental methods Relative replication capacity assay
Keywords class I down-regulation by Nef, escape, novel epitope

Notes

References

Shahid2015 Aniqa Shahid, Alex Olvera, Gursev Anmole, Xiaomei T. Kuang, Laura A. Cotton, Montserrat Plana, Christian Brander, Mark A. Brockman, and Zabrina L. Brumme. Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function. J. Virol., 89(22):11557-11571, Nov 2015. PubMed ID: 26355081. Show all entries for this paper.


Displaying record number 62890

Download this epitope record as JSON.

HXB2 Location Pol(488-496)
RT(333-341)
Pol Epitope Map
Author Location Pol
Epitope GQGQWTYQI Epitope Alignment
GQGQWTYQI epitope logo
Show epitope variants
Species (MHC/HLA) human
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA PubID 5050122: A*30, B*13:02; PubID 5051958: A*30, B*13:02; PubID 5051993: B*13:02
Experimental methods Other
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type DNA, polyepitope, adenovirus type 5 (Ad5), recombinant protein
Vaccine component Env, Gag, Nef, Pol

Notes

References

Boppana2020 Sushma Boppana, Andrew Fiore-Gartland, Anju Bansal, and Paul Goepfert. Cross-Reactive CD8 T-Cell Responses Elicited by Adenovirus Type 5-Based HIV-1 Vaccines Contributed to Early Viral Evolution in Vaccine Recipients Who Became Infected. J Virol, 94(2):JVI01632-19 doi, Jan 2020. PubMed ID: 31645444 Show all entries for this paper.


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