HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 57128

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location Gag(355-363)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Species (MHC/HLA) (B*07)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining, Relative replication capacity assay
Keywords escape, HLA associated polymorphism

Notes

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.


Displaying record number 59039

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location p24(355-363)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Show epitope variants
Epitope Name GL9-p24
Subtype C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country Japan, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, subtype comparisons

Notes

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 53981

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location ( C consensus)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Subtype C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 54180

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location (224-232)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Subtype C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Experimental methods Other
Keywords HLA associated polymorphism

Notes

References

Boutwell2007 Christian L. Boutwell and M. Essex. Identification of HLA Class I-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses, 23(1):165-174, Jan 2007. PubMed ID: 17263647. Show all entries for this paper.


Displaying record number 57960

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location Gag(355-363)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Show epitope variants
Epitope Name GL9
Subtype B
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country Australia
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords escape, HLA associated polymorphism

Notes

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 60947

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location p24(223-231)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Subtype B
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Patient MHC/HLA 63794: A*02:01:01G, B*07:02:01G, B*44:02:01G, C*07:04:01G
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 53330

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location ( C consensus)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Subtype C
Species (MHC/HLA) human(B*07:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 54601

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location Gag(355-363)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Show epitope variants
Subtype A, C, D
Species (MHC/HLA) human(B42, B7, B81)
Immunogen HIV-1 infection
Country Tanzania
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords subtype comparisons, immunodominance

Notes

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 58701

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location p24(355-363)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Epitope Name p24-GL9
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*30:01, B*42:01, C*17:01
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA associated polymorphism

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 59447

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location Gag(355-363)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Epitope Name Gag-GL9
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords immunodominance

Notes

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 56089

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location Gag
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Epitope Name Gag1150
Subtype C
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.


Displaying record number 1186

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location p24( SF2)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 1185

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location p24( SF2)
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons, immunodominance

Notes

References

Goulder2000 P. J. Goulder, C. Brander, K. Annamalai, N. Mngqundaniso, U. Govender, Y. Tang, S. He, K. E. Hartman, C. A. O'Callaghan, G. S. Ogg, M. A. Altfeld, E. S. Rosenberg, H. Cao, S. A. Kalams, M. Hammond, M. Bunce, S. I. Pelton, S. A. Burchett, K. McIntosh, H. M. Coovadia, and B. D. Walker. Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J. Virol., 74:5679-90, 2000. PubMed ID: 10823876. Show all entries for this paper.


Displaying record number 56967

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location Gag
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Subtype CRF01_AE
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 55972

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HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location p24
Epitope GPSHKARVL Epitope Alignment
GPSHKARVL epitope logo
Show epitope variants
Epitope Name GL9(p24)
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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