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Displaying record number 54389

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HXB2 Location	Nef(130-143) DNA(9184..9225)	Nef Epitope Map
Author Location
Epitope	GPGIRYPLTFGWCF	Epitope Alignment
Epitope Name	GF14
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

• Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
• HLA-B*57-restricted peptide GPGIRYPLTFGWCF was tested for immune response.

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.

Displaying record number 55854

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HXB2 Location	Nef(130-143) DNA(9184..9225)	Nef Epitope Map
Author Location	Nef(130-143)
Epitope	GPGIRYPLTFGWCF	Epitope Alignment
Epitope Name	GF14
Species (MHC/HLA)	human(B*58:01, B57)
Immunogen	HIV-1 infection
Country	Netherlands
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

• HLA-B57/5801 progressing and long term non-progressing HIV-1-infected individuals were compared to observe the reason for the difference in their clinical outcomes. LTNP non-progression to AIDS was associated with protective HLA-alleles B57/5801 and preserved CTL IFN-gamma response against the WT Nef epitope HW9. Progressing HIV-1 positive subjects expressed the inhibitory receptor PD-1 which reflects an exhausted CTL phenotype.
• Epitope GPGIRYPLTFGWCF had various variants in progressors - GPGvRYPLTFGWCF, GPGIRYPLcFGWCF, GPGvRfPLTFGWCF and GPGtRfPLTFGWCF.
• Epitope GPGIRYPLTFGWCF variants in LTNPs were - GPGvRhPLcFGWCF, GPGvRYPLcFGWCF, GPGvRYPLTFGWCF, GPGIRYPvTFGWCF and GPGvRYPLTFGWCy.
• Nef GF14 is previously known to be restricted by HLA-B57/5801.

References

Navis2008a Marjon Navis, Ingrid M. M. Schellens, Peter van Swieten, José A. M. Borghans, Frank Miedema, Neeltje A. Kootstra, Debbie van Baarle, and Hanneke Schuitemaker. A Nonprogressive Clinical Course in HIV-Infected Individuals Expressing Human Leukocyte Antigen B57/5801 Is Associated with Preserved CD8+ T Lymphocyte Responsiveness to the HW9 Epitope in Nef. J. Infect. Dis., 197(6):871-879, 15 Mar 2008. PubMed ID: 18279072. Show all entries for this paper.