HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 59713

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location Gag(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Epitope Name GK9
Species (MHC/HLA) human(A*30)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56360

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Epitope Name GK9
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords escape, HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 59712

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location Gag(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Epitope Name GK9
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55008

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Epitope Name GGK
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


Displaying record number 43

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32 LAI)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 58437

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location Gag(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Subtype A1
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Country Kenya
Experimental methods Other
Keywords assay or method development

Notes

References

Liang2011 Binhua Liang, Ma Luo, Joel Scott-Herridge, Christina Semeniuk, Mark Mendoza, Rupert Capina, Brent Sheardown, Hezhao Ji, Joshua Kimani, Blake T. Ball, Gary Van Domselaar, Morag Graham, Shane Tyler, Steven J. M. Jones, and Francis A. Plummer. A Comparison of Parallel Pyrosequencing and Sanger Clone-Based Sequencing and Its Impact on the Characterization of the Genetic Diversity of HIV-1. PLoS One, 6(10):e26745, 2011. PubMed ID: 22039546. Show all entries for this paper.


Displaying record number 48

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Species (MHC/HLA) human(B8)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.


Displaying record number 1368

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Epitope Name GGK
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI), immunodominance, acute/early infection

Notes

References

Oxenius2000b A. Oxenius, D. A. Price, P. J. Easterbrook, C. A. O'Callaghan, A. D. Kelleher, J. A. Whelan, G. Sontag, A. K. Sewell, and R. E. Phillips. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proc. Natl. Acad. Sci. U.S.A., 97(7):3382-7, 28 Mar 2000. URL: http://www.pnas.org/cgi/content/full/97/7/3382. PubMed ID: 10737796. Show all entries for this paper.


Displaying record number 41

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32 LAI)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Sutton1993 J. Sutton, S. Rowland-Jones, W. Rosenberg, D. Nixon, F. Gotch, X.-M. Gao, N. Murray, A. Spoonas, P. Driscoll, M. Smith, A. Willis, and A. McMichael. A Sequence Pattern for Peptides Presented to Cytotoxic T Lymphocytes by HLA B8 Revealed by Analysis of Epitopes and Eluted Peptides. Eur. J. Immunol., 23:447-453, 1993. PubMed ID: 7679646. Show all entries for this paper.


Displaying record number 54338

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Epitope Name B8-GK9(p17)
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54806

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location  
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Species (MHC/HLA) (B8)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, vaccine antigen design

Notes

References

Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.


Displaying record number 55710

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location Gag
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Epitope Name GK9-B08
Subtype B, F
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Country Argentina
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.


Displaying record number 52314

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Epitope Name GGK
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Oxenius2002b Annette Oxenius, Angela R. McLean, Marek Fischer, David A. Price, Sarah J. Dawson, Roland Hafner, Christine Schneider, Helen Joller, Bernard Hirschel, Rodney E. Phillips, Rainer Weber, Huldrych F. Günthard, and Swiss HIV Cohort Study Group. Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates During Structured Intermittent Antiretroviral Therapy. J. Virol., 76(20):10169-10176, Oct 2002. PubMed ID: 12239291. Show all entries for this paper.


Displaying record number 42

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32 LAI)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords epitope processing

Notes

References

RowlandJones1993a S. L. Rowland-Jones, S. H. Powis, J. Sutton, I. Mockridge, F. M. Gotch, N. Murray, A. B. Hill, W. M. Rosenberg, J. Trowsdale, and A. J. McMichael. An Antigen Processing Polymorphism Revealed by HLA-B8-Restricted Cytotoxic T Lymphocytes Which Does Not Correlate with TAP Gene Polymorphism. Eur. J. Immunol., 23:1999-2004, 1993. Individual fails to present HLA-B8-restricted influenza epitope, but can present an HLA-B8-restricted HIV-1 gag epitope. PubMed ID: 8344364. Show all entries for this paper.


Displaying record number 44

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Klenerman1994 P. Klenerman, S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Cytotoxic T Cell Activity Antagonized by Naturally Occurring HIV-1 Gag Variants. Nature, 369:403-407, 1994. This paper documents that naturally occurring peptide variants can serve as antagonists, that is they can inhibit normal lysis of cells presenting the original epitope. The variants studied could serve as antagonists when they were processed from recombinant vaccinia, replicated HIV, or when they were synthetic peptides. Both agonist and antagonist sequences were found in the study subjects from whom the CTL clones were derived. PubMed ID: 7515165. Show all entries for this paper.


Displaying record number 45

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Klenerman1995 P. Klenerman, U.-C. Meier, R. E. Phillips, and A. J. McMichael. The Effects of Natural Altered Peptide Ligands on the Whole Blood Cytotoxic T Lymphocyte Response to Human Immunodeficiency Virus. Eur. J. Immunol., 25:1927-1931, 1995. This paper explores naturally occurring altered peptide ligands and their ability to sustain CTL, serve as antagonists to CTL specific for other variants, and to allow cell killing. The authors propose that a CTL response may be sustained in vivo that fails to recognize viral variants as they arise, proposing a mechanism for T-cell original antigenic sin. PubMed ID: 7542596. Show all entries for this paper.


Displaying record number 46

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Show epitope variants
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords escape

Notes

References

Nowak1995 M. A. Nowak, R. M. May, R. E. Phillips, S. Rowland-Jones, D. G. Lalloo, S. McAdam, P. Klenerman, B. Koppe, K. Sigmund, C. R. M. Bangham, and A. J. McMichael. Antigenic Oscillations and Shifting Immunodominance in HIV-1 Infections. Nature, 375:606-611, 1995. This paper presents longitudinal studies of epitope variation and corresponding CTL responses in two patients. A mathematical model was created to provide a framework to explain the observed shifts in epitope and CTLp frequencies. For discussion, see also: J. M. Coffin, Nature 375:534-535 (1995). PubMed ID: 7791879. Show all entries for this paper.


Displaying record number 47

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Dyer1999 W. B. Dyer, G. S. Ogg, M. A. Demoitie, X. Jin, A. F. Geczy, S. L. Rowland-Jones, A. J. McMichael, D. F. Nixon, and J. S. Sullivan. Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected with nef-Defective HIV Type 1. J. Virol., 73:436-443, 1999. PubMed ID: 9847349. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Operated by Los Alamos National Security, LLC, for the U.S. Department of Energy's National Nuclear Security Administration
Copyright © 2006-2017 LANS LLC All rights reserved | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health