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Displaying record number 55676

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HXB2 Location	Gag(259-266) p24(127-134) DNA(1564..1587)	Gag Epitope Map
Author Location	Gag
Epitope	GDIYWKRWI	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(B*08:01)
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

• Transmission of HIV-1-escape variants from individuals with protective HLA-B*57/-B*5801 alleles to those without these alleles was studied to determine if infection with such replication-deficient mutants offered any advantage to the new host. Dependency between slower rate of disease progression in the newly infected subject and protective genotype of the infecting individual was suggested.
• HLA-B*0801-restricted epitope GDIYWKRWI, within peptide WMTSNPPVPVGDIYWKRWI was able to elicit CTL response in a T242N/A146X viral-mutation-carrying subject.

References

Chopera2008 Denis R. Chopera, Zenda Woodman, Koleka Mlisana, Mandla Mlotshwa, Darren P. Martin, Cathal Seoighe, Florette Treurnicht, Debra Assis de Rosa, Winston Hide, Salim Abdool Karim, Clive M. Gray, Carolyn Williamson, and CAPRISA 002 Study Team. Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage. PLoS Pathog, 4(3):e1000033, Mar 2008. PubMed ID: 18369479. Show all entries for this paper.